Publications by authors named "Benoit Coulombe"

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AI-Powered Identification of Human Cell Surface Protein Interactors of the Hemagglutinin Glycoprotein of High-Pandemic-Risk H5N1 Influenza Virus.
Christian Poitras, Benoit Coulombe

Viruses· December 2025

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MAGPIE: A Machine Learning Approach to Decipher Protein-Protein Interactions in Human Plasma.
Emily Hashimoto-Roth, Diane Forget, Vanessa P Gaspar, Steffany A L Bennett, Marie-Soleil Gauthier, Benoit Coulombe

J Proteome Res· February 2025

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Towards a Treatment for Leukodystrophy Using Cell-Based Interception and Precision Medicine.
Benoit Coulombe, Alexandra Chapleau, Julia Macintosh, Thomas M Durcan, Christian Poitras

Biomolecules· July 2024

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The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases.
Benoit Coulombe, Thomas M Durcan, Geneviève Bernard, Asmae Moursli, Christian Poitras

Mol Brain· April 2024

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Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization.
Nicolas Chofflet, Yusuke Naito, Anthony John Pastore, Nirmala Padmanabhan, Phuong Trang Nguyen, Benoit Coulombe

Front Mol Neurosci· March 2024

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Drugs targeting the particle for arrangement of quaternary structure (PAQosome) and protein complex assembly.
Maxime Pinard, Asmae Moursli, Benoit Coulombe

Expert Opin Drug Discov· January 2024

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ARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans.
Hongyu Luo, Linjiang Lao, Kit Sing Au, Hope Northrup, Xiao He, Benoit Coulombe

Genome Biol· January 2024

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Hypomyelination, hypodontia and craniofacial abnormalities in a Polr3b mouse model of leukodystrophy.
Mackenzie A Michell-Robinson, Kristin E N Watt, Vladimir Grouza, Julia Macintosh, Maxime Pinard, Benoit Coulombe

Brain· December 2023

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Biallelic pathogenic variants in alter tRNA transcription and cause a hypomyelinating leukodystrophy: A case report.
Julia Macintosh, Stefanie Perrier, Maxime Pinard, Luan T Tran, Kether Guerrero, Benoit Coulombe

Front Neurol· October 2023

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Riluzole partially restores RNA polymerase III complex assembly in cells expressing the leukodystrophy-causative variant POLR3B R103H.
Maxime Pinard, Samaneh Dastpeyman, Christian Poitras, Geneviève Bernard, Marie-Soleil Gauthier, Benoit Coulombe

Mol Brain· November 2022

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ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.
Linjiang Lao, Isabelle Bourdeau, Lucia Gagliardi, Xiao He, Wei Shi, Benoit Coulombe

Nucleic Acids Res· June 2022

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Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci.
Deepthi Sudarshan, Nikita Avvakumov, Marie-Eve Lalonde, Nader Alerasool, Charles Joly-Beauparlant, Benoit Coulombe

Genes Dev· June 2022

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Unphosphorylated Form of the PAQosome Core Subunit RPAP3 Binds Ribosomal Preassembly Complexes to Modulate Ribosome Biogenesis.
Maxime Pinard, Philippe Cloutier, Christian Poitras, Marie-Soleil Gauthier, Benoit Coulombe

J Proteome Res· April 2022

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De novo variants in POLR3B cause ataxia, spasticity, and demyelinating neuropathy.
Djurdja Djordjevic, Maxime Pinard, Marie-Soleil Gauthier, Constance Smith-Hicks, Trevor L Hoffman, Benoit Coulombe

Am J Hum Genet· April 2022

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Whole Exome/Genome Sequencing Joint Analysis of a Family with Oligogenic Familial Hypercholesterolemia.
Youmna Ghaleb, Sandy Elbitar, Anne Philippi, Petra El Khoury, Yara Azar, Benoit Coulombe

Metabolites· March 2022

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Analysis of the SARS-CoV-2-host protein interaction network reveals new biology and drug candidates: focus on the spike surface glycoprotein and RNA polymerase.
Esen Sokullu, Maxime Pinard, Marie-Soleil Gauthier, Benoit Coulombe

Expert Opin Drug Discov· August 2021

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Interactome Analysis of KIN (Kin17) Shows New Functions of This Protein.
Vanessa Pinatto Gaspar, Anelise Cardoso Ramos, Philippe Cloutier, José Renato Pattaro Junior, Francisco Ferreira Duarte Junior, Benoit Coulombe

Curr Issues Mol Biol· July 2021

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Variants in impair LSM complexes assembly, neurodevelopment in zebrafish and may be associated with an ultra-rare neurological disease.
Alexa Derksen, Hung-Yu Shih, Diane Forget, Lama Darbelli, Luan T Tran, Benoit Coulombe

HGG Adv· July 2021

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Discovery of Antivirals Using Phage Display.
Esen Sokullu, Marie-Soleil Gauthier, Benoit Coulombe

Viruses· June 2021

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POLR3-related leukodystrophy: How do mutations affecting RNA polymerase III subunits cause hypomyelination?
Benoit Coulombe, Alexa Derksen, Roberta La Piana, Bernard Brais, Marie-Soleil Gauthier

Fac Rev· February 2021

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De novo variants in POLR3B cause ataxia, spasticity, and demyelinating neuropathy.
Djurdja Djordjevic, Maxime Pinard, Marie-Soleil Gauthier, Constance Smith-Hicks, Trevor L Hoffman, Benoit Coulombe

Am J Hum Genet· January 2021

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Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome.
Philippe Cloutier, Christian Poitras, Denis Faubert, Annie Bouchard, Mathieu Blanchette, Benoit Coulombe

J Proteome Res· January 2020

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Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor).
Ali Ben Djoudi Ouadda, Marie-Soleil Gauthier, Delia Susan-Resiga, Emmanuelle Girard, Rachid Essalmani, Benoit Coulombe

Arterioscler Thromb Vasc Biol· October 2019

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The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis.
Karine Choquet, Maxime Pinard, Sharon Yang, Robyn D Moir, Christian Poitras, Benoit Coulombe

Mol Brain· June 2019

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Leukodystrophy-associated mutations down-regulate the RNA polymerase III transcript and important regulatory RNA .
Karine Choquet, Diane Forget, Elisabeth Meloche, Marie-Josée Dicaire, Geneviève Bernard, Benoit Coulombe

J Biol Chem· May 2019

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