Publications by authors named "Blake Pepinsky"

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Balancing brain exposure, pharmacokinetics and safety of transferrin receptor antibodies for delivery of neuro-therapeutics.
Benjamin A Smith, Caitlin B Meeks, Isabel Murray-Brown, Elizabeth A McCarthy, Mark C Julian, Blake Pepinsky

MAbs· December 2025

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Comparative assessment of binding and functional differences of clinical antibodies targeting α-synuclein in cellular models of Parkinson's disease.
YuTing Liu, Isin Dalkilic-Liddle, You Li, Benjamin A Smith, Thomas O Cameron, Blake Pepinsky

Biomed Pharmacother· August 2025

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Quantification of cinpanemab (BIIB054) binding to α-synuclein in cerebrospinal fluid of phase 1 single ascending dose samples.
YuTing Liu, Minhua Yang, Kyle Fraser, Danielle Graham, Paul H Weinreb, Blake Pepinsky

J Pharmacol Exp Ther· January 2025

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The anti-Müllerian hormone prodomain is displaced from the hormone/prodomain complex upon bivalent binding to the hormone receptor.
Richard L Cate, Nathalie di Clemente, Chrystèle Racine, Nigel P Groome, R Blake Pepinsky

J Biol Chem· January 2022

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Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site.
Karl J M Hanf, Joseph W Arndt, YuTing Liu, Bang Jian Gong, Mia Rushe, R Blake Pepinsky

MAbs· February 2021

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Tissue distribution of S-metabolically labeled neublastin (BG00010) in rats.
Natalia Penner, Shobha Purushothama, Blake Pepinsky

J Pharm Biomed Anal· May 2020

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Randomized phase I clinical trial of anti-α-synuclein antibody BIIB054.
Miroslaw Brys, Laura Fanning, Serena Hung, Aaron Ellenbogen, Natalia Penner, Blake Pepinsky

Mov Disord· August 2019

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Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.
Andreas Weihofen, YuTing Liu, Joseph W Arndt, Christian Huy, Chao Quan, R Blake Pepinsky

Neurobiol Dis· April 2019

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Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β.
Joseph W Arndt, Fang Qian, Benjamin A Smith, Chao Quan, Krishna Praneeth Kilambi, R Blake Pepinsky

Sci Rep· April 2018

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A Prodomain Fragment from the Proteolytic Activation of Growth Differentiation Factor 11 Remains Associated with the Mature Growth Factor and Keeps It Soluble.
Blake Pepinsky, Bang-Jian Gong, Yan Gao, Andreas Lehmann, Janine Ferrant

Biochemistry· August 2017

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Engineering potent long-acting variants of the Wnt inhibitor DKK2.
Richelle Sopko, Joshua W Mugford, Andreas Lehmann, Renée I Shapiro, Mia Rushe, Blake Pepinsky

Protein Eng Des Sel· May 2017

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Determination of the Disulfide Structure of Murine Meteorin, a Neurotrophic Factor, by LC-MS and Electron Transfer Dissociation-High-Energy Collisional Dissociation Analysis of Proteolytic Fragments.
Dingyi Wen, Yongsheng Xiao, Malgorzata M Vecchi, Bang Jian Gong, Jana Dolnikova, R Blake Pepinsky

Anal Chem· April 2017

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LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway.
Zhaohui Shao, Xinhua Lee, Guanrong Huang, Guoqing Sheng, Christopher E Henderson, Blake Pepinsky

J Neurosci· March 2017

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Most Cleaved Anti-Müllerian Hormone Binds Its Receptor in Human Follicular Fluid but Little Is Competent in Serum.
Alice Pierre, Chrystèle Racine, Rodolfo A Rey, Renato Fanchin, Joëlle Taieb, R Blake Pepinsky

J Clin Endocrinol Metab· December 2016

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Investigating the Role of Artemin Glycosylation.
Qiu Danwen, Christian Code, Chao Quan, Bang-Jin Gong, Joseph Arndt, Blake Pepinsky

Pharm Res· June 2016

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Blocking LINGO-1 in vivo reduces degeneration and enhances regeneration of the optic nerve.
Melissa M Gresle, Yaou Liu, Trevor J Kilpatrick, Dennis Kemper, Qi-Zhu Wu, Blake Pepinsky

Mult Scler J Exp Transl Clin· April 2016

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Artemin promotes functional long-distance axonal regeneration to the brainstem after dorsal root crush.
Laura Elisabeth Wong, Molly E Gibson, H Moore Arnold, Blake Pepinsky, Eric Frank

Proc Natl Acad Sci U S A· May 2015

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Constitutive negative regulation in the processing of the anti-Müllerian hormone receptor II.
Tal Hirschhorn, Nathalie di Clemente, Ayelet R Amsalem, R Blake Pepinsky, Jean-Yves Picard

J Cell Sci· April 2015

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Inhibition of LINGO-1 promotes functional recovery after experimental spinal cord demyelination.
Yongjie Zhang, Yi Ping Zhang, Blake Pepinsky, Guanrong Huang, Lisa B E Shields

Exp Neurol· April 2015

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A novel platform for engineering blood-brain barrier-crossing bispecific biologics.
Graham K Farrington, Nadia Caram-Salas, Arsalan S Haqqani, Eric Brunette, John Eldredge, Blake Pepinsky

FASEB J· November 2014

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Structure of the LINGO-1-anti-LINGO-1 Li81 antibody complex provides insights into the biology of LINGO-1 and the mechanism of action of the antibody therapy.
R Blake Pepinsky, Joseph W Arndt, Chao Quan, Yan Gao, Omar Quintero-Monzon

J Pharmacol Exp Ther· July 2014

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LINGO-1 regulates oligodendrocyte differentiation by inhibiting ErbB2 translocation and activation in lipid rafts.
Xinhua Lee, Zhaohui Shao, Guoqing Sheng, Blake Pepinsky, Sha Mi

Mol Cell Neurosci· May 2014

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Antibody humanization by redesign of complementarity-determining region residues proximate to the acceptor framework.
Karl J M Hanf, Joseph W Arndt, Ling Ling Chen, Matthew Jarpe, P Ann Boriack-Sjodin, R Blake Pepinsky

Methods· January 2014

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Blocking LINGO-1 as a therapy to promote CNS repair: from concept to the clinic.
Sha Mi, R Blake Pepinsky, Diego Cadavid

CNS Drugs· July 2013

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Dynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain.
Paul H Weinreb, Sheng Li, Sharon X Gao, Tong Liu, R Blake Pepinsky

J Biol Chem· September 2012

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