Publications by authors named "Brett A Colson"

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MYBPC3 N-terminal missense mutations linked to hypertrophic cardiomyopathy strengthen actin binding and enhance residue mobility.
Rhye-Samuel Kanassatega, Thomas A Bunch, Fiona L Wong, L Michel Espinoza-Fonseca, Brett A Colson

J Biol Chem· October 2025

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Myosin Mayhem: Losing (or Gaining) Its Chill in Hypertrophic Cardiomyopathy.
Brett A Colson

Circ Heart Fail· September 2025

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cMyBP-C in hypertrophic cardiomyopathy: gene therapy and small-molecule innovations.
Patrick T Wood, Morgan M Seffrood, Brett A Colson, Julian E Stelzer

Front Cardiovasc Med· February 2025

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Cardiac myosin-binding protein C N-terminal interactions with myosin and actin filaments: Opposite effects of phosphorylation and M-domain mutations.
Fiona L Wong, Thomas A Bunch, Victoria C Lepak, Allison L Steedman, Brett A Colson

J Mol Cell Cardiol· January 2024

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Drug discovery for heart failure targeting myosin-binding protein C.
Thomas A Bunch, Piyali Guhathakurta, Andrew R Thompson, Victoria C Lepak, Anna L Carter, Brett A Colson

J Biol Chem· December 2023

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Drug discovery for heart failure targeting myosin-binding protein C.
Thomas A Bunch, Piyali Guhathakurta, Andrew R Thompson, Victoria C Lepak, Anna L Carter, Brett A Colson

bioRxiv· April 2023

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Fluorescence lifetime-based assay reports structural changes in cardiac muscle mediated by effectors of contractile regulation.
Alexey V Dvornikov, Thomas A Bunch, Victoria C Lepak, Brett A Colson

J Gen Physiol· March 2023

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Human cardiac myosin-binding protein C phosphorylation- and mutation-dependent structural dynamics monitored by time-resolved FRET.
Rhye-Samuel Kanassatega, Thomas A Bunch, Victoria C Lepak, Christopher Wang, Brett A Colson

J Mol Cell Cardiol· May 2022

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AZD2014, a dual mTOR inhibitor, attenuates cardiac hypertrophy in vitro and in vivo.
Byung-Hyun Cha, Minjin Jung, Angela S Kim, Victoria C Lepak, Brett A Colson

J Biol Eng· October 2021

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Cardiac myosin-binding protein C interaction with actin is inhibited by compounds identified in a high-throughput fluorescence lifetime screen.
Thomas A Bunch, Piyali Guhathakurta, Victoria C Lepak, Andrew R Thompson, Rhye-Samuel Kanassatega, Brett A Colson

J Biol Chem· July 2021

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In the eye of the STORM: Tracking the myosin-binding protein C N terminus in heart muscle.
Brett A Colson

J Gen Physiol· March 2021

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A high-throughput fluorescence lifetime-based assay to detect binding of myosin-binding protein C to F-actin.
Thomas A Bunch, Victoria C Lepak, Kellan M Bortz, Brett A Colson

J Gen Physiol· March 2021

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Human cardiac myosin-binding protein C restricts actin structural dynamics in a cooperative and phosphorylation-sensitive manner.
Thomas A Bunch, Rhye-Samuel Kanassatega, Victoria C Lepak, Brett A Colson

J Biol Chem· November 2019

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What a drag!: Skeletal myosin binding protein-C affects sarcomeric shortening.
Brett A Colson

J Gen Physiol· May 2019

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Age affects myosin relaxation states in skeletal muscle fibers of female but not male mice.
Lien A Phung, Sira M Karvinen, Brett A Colson, David D Thomas, Dawn A Lowe

PLoS One· February 2019

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N-terminal extension in cardiac myosin-binding protein C regulates myofilament binding.
Thomas A Bunch, Victoria C Lepak, Rhye-Samuel Kanassatega, Brett A Colson

J Mol Cell Cardiol· December 2018

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Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury.
Sunmi Palumbo, Yoon-Joo Shin, Kareem Ahmad, Ankit A Desai, Hector Quijada, Brett A Colson

Am J Physiol Lung Cell Mol Physiol· March 2017

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Estradiol modulates myosin regulatory light chain phosphorylation and contractility in skeletal muscle of female mice.
Shaojuan Lai, Brittany C Collins, Brett A Colson, Georgios Kararigas, Dawn A Lowe

Am J Physiol Endocrinol Metab· May 2016

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Site-directed spectroscopy of cardiac myosin-binding protein C reveals effects of phosphorylation on protein structural dynamics.
Brett A Colson, Andrew R Thompson, L Michel Espinoza-Fonseca, David D Thomas

Proc Natl Acad Sci U S A· March 2016

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The myosin super-relaxed state is disrupted by estradiol deficiency.
Brett A Colson, Karl J Petersen, Brittany C Collins, Dawn A Lowe, David D Thomas

Biochem Biophys Res Commun· January 2015

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Effects of pseudophosphorylation mutants on the structural dynamics of smooth muscle myosin regulatory light chain.
L Michel Espinoza-Fonseca, Brett A Colson, David D Thomas

Mol Biosyst· October 2014

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Structural dynamics of muscle protein phosphorylation.
Brett A Colson, Simon J Gruber, David D Thomas

J Muscle Res Cell Motil· December 2012

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Cardiac myosin binding protein-C restricts intrafilament torsional dynamics of actin in a phosphorylation-dependent manner.
Brett A Colson, Inna N Rybakova, Ewa Prochniewicz, Richard L Moss, David D Thomas

Proc Natl Acad Sci U S A· December 2012

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Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium.
Brett A Colson, Jitandrakumar R Patel, Peter P Chen, Tanya Bekyarova, Mohamed I Abdalla

J Mol Cell Cardiol· November 2012

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Differential roles of regulatory light chain and myosin binding protein-C phosphorylations in the modulation of cardiac force development.
Brett A Colson, Matthew R Locher, Tanya Bekyarova, Jitandrakumar R Patel, Daniel P Fitzsimons

J Physiol· March 2010

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