Publications by authors named "Brian Button"

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STAT3-Dependent Regulation of CFTR and Ciliogenesis Is Essential for Mucociliary Clearance and Innate Airway Defense in Hyper-IgE Syndrome.
Ling Sun, Samantha A Walls, Hong Dang, Nancy L Quinney, Patrick R Sears, Brian Button

Am J Respir Crit Care Med· October 2025

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Heat waves elevate risks of airway hypersensitivity that inhaled endogenous ions reduce.
David Edwards, Brian Button, Aurelie Edwards, Kian Fan Chung, Hong Dang

Res Sq· October 2025

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Hyaluronan Ameliorates Viral Pneumonia in Mice and Humans by Inhibiting E2F1 Transcription Factor.
Vandy P Stober, Carol S Trempus, Flavia Galdi, Negin P Martin, Wesley Gladwell, Brian Button

Am J Respir Cell Mol Biol· July 2025

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Global warming risks dehydrating and inflaming human airways.
David A Edwards, Aurélie Edwards, Dan Li, Linying Wang, Kian Fan Chung, Brian Button

Commun Earth Environ· March 2025

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Dysregulated Airway Host Defense in Hyper IgE Syndrome due to STAT3 Mutations.
Ling Sun, Samantha A Walls, Hong Dang, Nancy L Quinney, Patrick R Sears, Brian Button

bioRxiv· August 2024

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TRPV2 modulates mechanically Induced ATP Release from Human bronchial epithelial cells.
Orla M Dunne, S Lorraine Martin, Gerard P Sergeant, Daniel F McAuley, Cecilia M O'Kane, Brian Button

Respir Res· April 2024

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BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance.
Lauren J Donoghue, Matthew R Markovetz, Cameron B Morrison, Gang Chen, Kathryn M McFadden, Brian Button

Am J Physiol Lung Cell Mol Physiol· December 2023

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Aromatic pentaamide macrocycles bind anions with high affinity for transport across biomembranes.
Ruikai Cao, Robert B Rossdeutcher, Yulong Zhong, Yi Shen, Daniel P Miller, Brian Button

Nat Chem· November 2023

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Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration.
Yu Mikami, Barbara R Grubb, Troy D Rogers, Hong Dang, Takanori Asakura, Brian Button

Sci Transl Med· June 2023

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Physiology and pathophysiology of human airway mucus.
David B Hill, Brian Button, Michael Rubinstein, Richard C Boucher

Physiol Rev· October 2022

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Mucus-targeting therapies of defective mucus clearance for cystic fibrosis: A short review.
Miriam Frankenthal Figueira, Carla M P Ribeiro, Brian Button

Curr Opin Pharmacol· August 2022

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Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.
Scott B Biering, Sylvia A Sarnik, Eleanor Wang, James R Zengel, Sarah R Leist, Brian Button

Nat Genet· August 2022

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Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis.
Takafumi Kato, Giorgia Radicioni, Micah J Papanikolas, Georgi V Stoychev, Matthew R Markovetz, Brian Button

Sci Adv· April 2022

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Regional Differences in Mucociliary Clearance in the Upper and Lower Airways.
Troy D Rogers, Brian Button, Samir N P Kelada, Lawrence E Ostrowski, Alessandra Livraghi-Butrico

Front Physiol· March 2022

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A mucoadhesive biodissolvable thin film for localized and rapid delivery of lidocaine for the treatment of vestibulodynia.
Denali K Dahl, Ashlyn N Whitesell, Preetika Sharma-Huynh, Panita Maturavongsadit, Rima Janusziewicz, Brian Button

Int J Pharm· January 2022

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Airway Epithelial Nucleotide Release Contributes to Mucociliary Clearance.
Catharina van Heusden, Barbara R Grubb, Brian Button, Eduardo R Lazarowski

Life (Basel)· May 2021

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Effect of hypertonic saline on mucociliary clearance and clinical outcomes in chronic bronchitis.
William D Bennett, Ashley G Henderson, Agathe Ceppe, Kirby L Zeman, Jihong Wu, Brian Button

ERJ Open Res· July 2020

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TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis.
Henry L Danahay, Sarah Lilley, Roy Fox, Holly Charlton, Juan Sabater, Brian Button

Am J Respir Crit Care Med· April 2020

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Airway Mucus Hyperconcentration in Non-Cystic Fibrosis Bronchiectasis.
Kathryn A Ramsey, Alice C H Chen, Giorgia Radicioni, Rohan Lourie, Megan Martin, Brian Button

Am J Respir Crit Care Med· March 2020

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Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia.
Catharina van Heusden, Brian Button, Wayne H Anderson, Agathe Ceppe, Lisa C Morton

Am J Physiol Lung Cell Mol Physiol· February 2020

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The Cystic Fibrosis-Like Airway Surface Layer Is not a Significant Barrier for Delivery of Eluforsen to Airway Epithelial Cells.
Vera Brinks, Katarzyna Lipinska, Miranda de Jager, Wouter Beumer, Brian Button

J Aerosol Med Pulm Drug Deliv· October 2019

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IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis.
Gang Chen, Ling Sun, Takafumi Kato, Kenichi Okuda, Mary B Martino, Brian Button

J Clin Invest· October 2019

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Adhesive and Cohesive Peel Force Measurement of Human Airway Mucus.
Henry P Goodell, Siddharth K Shenoy, Nathan T Shenkute, Elijah Lackey, Robert G Dennis, Brian Button

Bio Protoc· July 2019

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Roles of mucus adhesion and cohesion in cough clearance.
Brian Button, Henry P Goodell, Eyad Atieh, Yu-Cheng Chen, Robert Williams

Proc Natl Acad Sci U S A· December 2018

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Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum.
Ashley G Henderson, Wayne H Anderson, Agathe Ceppe, Raymond D Coakley, Brian Button

COPD· December 2018

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