Publications by authors named "Brian D Hudson"

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Intracrine FFA4 signaling controls lipolysis at lipid droplets.
Shannon L O'Brien, Emma Tripp, Natasja Barki, Elodie Blondel-Tepaz, Gabrielle Smith, Brian D Hudson

Nat Chem Biol· August 2025

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Multicolored sequential resonance energy transfer for detection of simultaneous ligand binding at G protein-coupled receptors.
Alice Valentini, Bethany Dibnah, Marija Ciba, Elaine M Duncan, Asmita Manandhar, Brian D Hudson

Nat Commun· July 2025

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Biased constitutive signaling of the G protein-coupled receptor GPR35 suppresses gut barrier permeability.
Tezz Quon, Li-Chiung Lin, Amlan Ganguly, Brian D Hudson, Andrew B Tobin

J Biol Chem· January 2025

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Development and Characterization of Potent Succinate Receptor Fluorescent Tracers.
Marija Ciba, Bethany Dibnah, Brian D Hudson, Elisabeth Rexen Ulven

J Med Chem· July 2023

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Metabolite-sensing GPCRs controlling interactions between adipose tissue and inflammation.
Elaine M Duncan, Luca Vita, Bethany Dibnah, Brian D Hudson

Front Endocrinol (Lausanne)· July 2023

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Pleiotropic effects of Syntaxin16 identified by gene editing in cultured adipocytes.
Shaun K Bremner, Woroud S Al Shammari, Roderick S Milligan, Brian D Hudson, Calum Sutherland

Front Cell Dev Biol· November 2022

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Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor.
Nina Divorty, Laura Jenkins, Amlan Ganguly, Adrian J Butcher, Brian D Hudson

J Biol Chem· March 2022

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Chemogenetics defines a short-chain fatty acid receptor gut-brain axis.
Natasja Barki, Daniele Bolognini, Ulf Börjesson, Laura Jenkins, John Riddell, Brian D Hudson

Elife· March 2022

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Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease.
Miriam Scarpa, Colin Molloy, Laura Jenkins, Bethany Strellis, Rebecca F Budgett, Brian D Hudson

Proc Natl Acad Sci U S A· December 2021

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Structure-Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2.
Anders Højgaard Hansen, Henriette B Christensen, Sunil K Pandey, Eugenia Sergeev, Alice Valentini, Brian D Hudson

ChemMedChem· November 2021

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From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Alastair J H Brown, Sophie J Bradley, Fiona H Marshall, Giles A Brown, Kirstie A Bennett, Brian D Hudson

Cell· November 2021

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Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators.
Elisabeth Rexen Ulven, Tezz Quon, Eugenia Sergeev, Natasja Barki, Matjaz Brvar, Brian D Hudson

J Med Chem· April 2020

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Chemogenetics defines receptor-mediated functions of short chain free fatty acids.
Daniele Bolognini, Natasja Barki, Adrian J Butcher, Brian D Hudson, Eugenia Sergeev

Nat Chem Biol· May 2019

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Receptor selectivity between the G proteins Gα and Gα is defined by a single leucine-to-isoleucine variation.
Amanda E Mackenzie, Tezz Quon, Li-Chiung Lin, Alexander S Hauser, Laura Jenkins, Brian D Hudson

FASEB J· April 2019

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Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84.
Zobaer Al Mahmud, Laura Jenkins, Trond Ulven, Frédéric Labéguère, Romain Gosmini, Brian D Hudson

Sci Rep· December 2017

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A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias.
Eugenia Sergeev, Anders Højgaard Hansen, Daniele Bolognini, Kouki Kawakami, Takayuki Kishi, Brian D Hudson

Sci Rep· October 2017

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Using Biosensors to Study Free Fatty Acid Receptor Pharmacology and Function.
Brian D Hudson

Handb Exp Pharmacol· September 2017

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FFA4/GPR120: Pharmacology and Therapeutic Opportunities.
Graeme Milligan, Elisa Alvarez-Curto, Brian D Hudson, Rudi Prihandoko, Andrew B Tobin

Trends Pharmacol Sci· September 2017

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Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43).
Anders Højgaard Hansen, Eugenia Sergeev, Sunil K Pandey, Brian D Hudson, Elisabeth Christiansen

J Med Chem· July 2017

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Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4.
Kenneth R Watterson, Steffen V F Hansen, Brian D Hudson, Elisa Alvarez-Curto, Sheikh Zahir Raihan

Mol Pharmacol· June 2017

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Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance.
Julia M Houthuijzen, Ilse Oosterom, Brian D Hudson, Akira Hirasawa, Laura G M Daenen

FASEB J· May 2017

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Complex Pharmacology of Free Fatty Acid Receptors.
Graeme Milligan, Bharat Shimpukade, Trond Ulven, Brian D Hudson

Chem Rev· January 2017

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Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity.
Carlos M G Azevedo, Kenneth R Watterson, Ed T Wargent, Steffen V F Hansen, Brian D Hudson

J Med Chem· October 2016

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Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer.
Elisabeth Christiansen, Brian D Hudson, Anders Højgaard Hansen, Graeme Milligan, Trond Ulven

J Med Chem· May 2016

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A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor.
Manuel Grundmann, Irina G Tikhonova, Brian D Hudson, Nicola J Smith, Klaus Mohr

Cell Chem Biol· March 2016

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