Publications by authors named "Adrian J Butcher"

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PERK-ATAD3A interaction provides a subcellular safe haven for protein synthesis during ER stress.
Karinder K Brar, Daniel T Hughes, Jordan L Morris, Kelly Subramanian, Shivaani Krishna, Adrian J Butcher

Science· August 2024

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Trazodone rescues dysregulated synaptic and mitochondrial nascent proteomes in prion neurodegeneration.
Hector Albert-Gasco, Heather L Smith, Beatriz Alvarez-Castelao, Dean Swinden, Mark Halliday, Adrian J Butcher

Brain· February 2024

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Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands.
Sara Marsango, Richard J Ward, Laura Jenkins, Adrian J Butcher, Zobaer Al Mahmud

J Biol Chem· May 2022

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Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor.
Nina Divorty, Laura Jenkins, Amlan Ganguly, Adrian J Butcher, Brian D Hudson

J Biol Chem· March 2022

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Targeting the Unfolded Protein Response as a Disease-Modifying Pathway in Dementia.
Emad Sidhom, John T O'Brien, Adrian J Butcher, Heather L Smith, Giovanna R Mallucci

Int J Mol Sci· February 2022

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Targeting the kinase insert loop of PERK selectively modulates PERK signaling without systemic toxicity in mice.
Daniel T Hughes, Mark Halliday, Heather L Smith, Nicholas C Verity, Colin Molloy, Adrian J Butcher

Sci Signal· August 2020

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Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration.
Heather L Smith, Oliver J Freeman, Adrian J Butcher, Staffan Holmqvist, Ibrahim Humoud

Neuron· March 2020

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Chemogenetics defines receptor-mediated functions of short chain free fatty acids.
Daniele Bolognini, Natasja Barki, Adrian J Butcher, Brian D Hudson, Eugenia Sergeev

Nat Chem Biol· May 2019

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M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss.
Sophie J Bradley, Julie-Myrtille Bourgognon, Helen E Sanger, Nicholas Verity, Adrian J Mogg, Adrian J Butcher

J Clin Invest· February 2017

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Identification of key phosphorylation sites in PTH1R that determine arrestin3 binding and fine-tune receptor signaling.
Diana Zindel, Sandra Engel, Andrew R Bottrill, Jean-Philippe Pin, Laurent Prézeau, Adrian J Butcher

Biochem J· November 2016

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Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein-Coupled Receptor 120.
Rudi Prihandoko, Elisa Alvarez-Curto, Brian D Hudson, Adrian J Butcher, Trond Ulven

Mol Pharmacol· May 2016

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An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory.
Adrian J Butcher, Sophie J Bradley, Rudi Prihandoko, Simon M Brooke, Adrian Mogg

J Biol Chem· April 2016

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Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction.
Sophie J Bradley, Coen H Wiegman, Max Maza Iglesias, Kok Choi Kong, Adrian J Butcher

Proc Natl Acad Sci U S A· April 2016

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Distinct phosphorylation sites on the ghrelin receptor, GHSR1a, establish a code that determines the functions of ß-arrestins.
Monica Bouzo-Lorenzo, Icía Santo-Zas, Maria Lodeiro, Rubén Nogueiras, Felipe F Casanueva, Adrian J Butcher

Sci Rep· March 2016

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CK2 acts as a potent negative regulator of receptor-mediated insulin release in vitro and in vivo.
Mario Rossi, Inigo Ruiz de Azua, Luiz F Barella, Wataru Sakamoto, Lu Zhu, Adrian J Butcher

Proc Natl Acad Sci U S A· December 2015

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The experimental power of FR900359 to study Gq-regulated biological processes.
Ramona Schrage, Anna-Lena Schmitz, Evelyn Gaffal, Suvi Annala, Stefan Kehraus, Adrian J Butcher

Nat Commun· December 2015

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Determination of GPCR Phosphorylation Status: Establishing a Phosphorylation Barcode.
Rudi Prihandoko, Sophie J Bradley, Andrew B Tobin, Adrian J Butcher

Curr Protoc Pharmacol· June 2015

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Engineered hyperphosphorylation of the β2-adrenoceptor prolongs arrestin-3 binding and induces arrestin internalization.
Diana Zindel, Adrian J Butcher, Suleiman Al-Sabah, Peter Lanzerstorfer, Julian Weghuber

Mol Pharmacol· February 2015

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Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4.
Adrian J Butcher, Brian D Hudson, Bharat Shimpukade, Elisa Alvarez-Curto, Rudi Prihandoko

J Biol Chem· June 2014

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The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism.
Brian D Hudson, Bharat Shimpukade, Amanda E Mackenzie, Adrian J Butcher, John D Pediani

Mol Pharmacol· November 2013

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Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor.
Ying-Ju Chen, Sue Oldfield, Adrian J Butcher, Andrew B Tobin, Kunal Saxena

J Neurochem· January 2013

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Physiological role of G-protein coupled receptor phosphorylation.
Adrian J Butcher, Kok Choi Kong, Rudi Prihandoko, Andrew B Tobin

Handb Exp Pharmacol· April 2012

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Examining site-specific GPCR phosphorylation.
Adrian J Butcher, Andrew B Tobin, Kok Choi Kong

Methods Mol Biol· September 2011

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Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code.
Adrian J Butcher, Rudi Prihandoko, Kok Choi Kong, Phillip McWilliams, Jennifer M Edwards

J Biol Chem· April 2011

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M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1.
Kok Choi Kong, Adrian J Butcher, Phillip McWilliams, David Jones, Jürgen Wess

Proc Natl Acad Sci U S A· December 2010

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