Publications by authors named "John D Pediani"

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The M muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes.
Sara Marsango, Laura Jenkins, John D Pediani, Sophie J Bradley, Richard J Ward

Proc Natl Acad Sci U S A· June 2022

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Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t.
Richard J Ward, John D Pediani, Sara Marsango, Richard Jolly, Michael R Stoneman

J Biol Chem· August 2021

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A general method to quantify ligand-driven oligomerization from fluorescence-based images.
Michael R Stoneman, Gabriel Biener, Richard J Ward, John D Pediani, Dammar Badu

Nat Methods· June 2019

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Visualization of the activation of the histamine H3 receptor (H3R) using novel fluorescence resonance energy transfer biosensors and their potential application to the study of H3R pharmacology.
Ying Liu, Hong Zeng, John D Pediani, Richard J Ward, Lu-Yao Chen

FEBS J· June 2018

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Spatial Intensity Distribution Analysis: Studies of G Protein-Coupled Receptor Oligomerisation.
John D Pediani, Richard J Ward, Sara Marsango, Graeme Milligan

Trends Pharmacol Sci· February 2018

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Multiple AMPK activators inhibit l-carnitine uptake in C2C12 skeletal muscle myotubes.
Andy Shaw, Stewart Jeromson, Kenneth R Watterson, John D Pediani, Iain J Gallagher

Am J Physiol Cell Physiol· June 2017

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Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor.
Richard J Ward, John D Pediani, Kaleeckal G Harikumar, Laurence J Miller, Graeme Milligan

Biochem J· May 2017

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A Molecular Basis for Selective Antagonist Destabilization of Dopamine D Receptor Quaternary Organization.
Sara Marsango, Gianluigi Caltabiano, Mireia Jiménez-Rosés, Mark J Millan, John D Pediani

Sci Rep· May 2017

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Dynamic Regulation of Quaternary Organization of the M1 Muscarinic Receptor by Subtype-selective Antagonist Drugs.
John D Pediani, Richard J Ward, Antoine G Godin, Sara Marsango, Graeme Milligan

J Biol Chem· June 2016

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Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis.
Richard J Ward, John D Pediani, Antoine G Godin, Graeme Milligan

J Biol Chem· May 2015

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Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2.
Linas Zakrys, Richard J Ward, John D Pediani, Antoine G Godin, Gerard J Graham

Biochem J· July 2014

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The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism.
Brian D Hudson, Bharat Shimpukade, Amanda E Mackenzie, Adrian J Butcher, John D Pediani

Mol Pharmacol· November 2013

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The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun.
Jolanta Wiejak, Julia Dunlop, Chloe Stoyle, Gillian Lappin, Anna McIlroy, John D Pediani

Cell Signal· August 2012

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Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4).
Margaret R Cunningham, Kathryn A McIntosh, John D Pediani, Joris Robben, Alexandra E Cooke

J Biol Chem· May 2012

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Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation.
Tian-Rui Xu, Richard J Ward, John D Pediani, Graeme Milligan

J Biol Chem· April 2012

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Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL).
Elisa Alvarez-Curto, Rudi Prihandoko, Christofer S Tautermann, Jurriaan M Zwier, John D Pediani

Mol Pharmacol· December 2011

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The orexin OX(1) receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands.
Tian-Rui Xu, Richard J Ward, John D Pediani, Graeme Milligan

Biochem J· October 2011

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Heteromultimerization of cannabinoid CB(1) receptor and orexin OX(1) receptor generates a unique complex in which both protomers are regulated by orexin A.
Richard J Ward, John D Pediani, Graeme Milligan

J Biol Chem· October 2011

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Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.
Richard J Ward, John D Pediani, Graeme Milligan

Br J Pharmacol· March 2011

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Applications of fluorescence and bioluminescence resonance energy transfer to drug discovery at G protein coupled receptors.
Elisa Alvarez-Curto, John D Pediani, Graeme Milligan

Anal Bioanal Chem· September 2010

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Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogeneous time-resolved FRET.
Elisa Alvarez-Curto, Richard J Ward, John D Pediani, Graeme Milligan

J Biol Chem· July 2010

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Agonist occupancy of a single monomeric element is sufficient to cause internalization of the dimeric beta2-adrenoceptor.
Nana Sartania, Shirley Appelbe, John D Pediani, Graeme Milligan

Cell Signal· September 2007

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The alpha1b-adrenoceptor exists as a higher-order oligomer: effective oligomerization is required for receptor maturation, surface delivery, and function.
Juan F Lopez-Gimenez, Meritxell Canals, John D Pediani, Graeme Milligan

Mol Pharmacol· April 2007

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Oligomeric structure of the alpha1b-adrenoceptor: comparisons with rhodopsin.
Graeme Milligan, John D Pediani, Meritxell Canals, Juan F Lopez-Gimenez

Vision Res· December 2006

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Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function.
James Ellis, John D Pediani, Meritxell Canals, Sandra Milasta, Graeme Milligan

J Biol Chem· December 2006

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