Publications by authors named "Brian Guth"

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Implementation of automated blood sampling in a canine cardiovascular safety pharmacology study to support PK/PD assessment.
Elham Ataei Alizadeh, Georg Rast, Jessica Schiwon, Thomas Trautmann, Chris Cantow, Brian D Guth

J Pharmacol Toxicol Methods· September 2025

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Optimization of bioanalysis of dried blood samples.
Elham Ataei Alizadeh, Georg Rast, Chris Cantow, Jessica Schiwon, Florian Krause, Brian D Guth

J Pharmacol Toxicol Methods· November 2023

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The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies.
Elham Ataei Alizadeh, Thomas Trautmann, Florian Krause, Benjamin Knoeferl, Pieter-Jan Guns, Brian D Guth

J Pharmacol Toxicol Methods· October 2023

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Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization.
Elham Ataei Alizadeh, Karin Graf, Jessica Schiwon, Thomas Trautmann, Florian Krause, Brian D Guth

J Pharmacol Toxicol Methods· July 2023

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Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.
Hugo M Vargas, Michael G Rolf, Todd A Wisialowski, William Achanzar, Anthony Bahinski, Brian Guth

Clin Pharmacol Ther· February 2021

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INSPIRE: A European training network to foster research and training in cardiovascular safety pharmacology.
Pieter-Jan D Guns, Brian D Guth, Stefan Braam, Georgios Kosmidis, Elena Matsa

J Pharmacol Toxicol Methods· September 2020

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Echocardiographic and hemodynamic indices of myocardial contractility simultaneously evaluated in telemetered beagle dogs: A HESI-sponsored cross-company evaluation.
Eric I Rossman, Frank Cools, Jason Cordes, Deborah Dhuyvetter, Jennifer M Doyle, Brian Guth

J Pharmacol Toxicol Methods· September 2020

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Comparison of in vitro and computational experiments on the relation of inter-beat interval and duration of repolarization in a specific type of human induced pluripotent stem cell-derived cardiomyocytes.
Philipp Kügler, Georg Rast, Brian D Guth

PLoS One· March 2020

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Drug safety Africa: An overview of safety pharmacology & toxicology in South Africa.
Brian D Guth, Anne F Grobler, Kendall S Frazier, Andrea Greiter-Wilke, Danuta Herzyk

J Pharmacol Toxicol Methods· January 2020

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Considerations for an , Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms.
Brian D Guth, Michael Engwall, Sandy Eldridge, C Michael Foley, Liang Guo

Front Pharmacol· August 2019

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Considerations for an , Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes.
Alexandre J S Ribeiro, Brian D Guth, Michael Engwall, Sandy Eldridge, C Michael Foley

Front Pharmacol· August 2019

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A new telemetry-based system for assessing cardiovascular function in group-housed large animals. Taking the 3Rs to a new level with the evaluation of remote measurement via cloud data transmission.
Michael Markert, Thomas Trautmann, Florian Krause, Marius Cioaga, Sebastien Mouriot, Brian D Guth

J Pharmacol Toxicol Methods· January 2019

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Safety pharmacology in and for Africa: Establishment of the pre-clinical drug development platform.
Brian D Guth, Anne Grobler

J Pharmacol Toxicol Methods· January 2019

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The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs.
Alan Y Chiang, Brian D Guth, Michael K Pugsley, C Michael Foley, Jennifer M Doyle

J Pharmacol Toxicol Methods· October 2018

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An evaluation of the utility of LVdP/dt, QA interval, LVdP/dt and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs.
Michael K Pugsley, Brian Guth, Alan Y Chiang, Jennifer M Doyle, Michael Engwall

J Pharmacol Toxicol Methods· April 2018

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GLP in safety pharmacology studies: Report card after 15years.
Brian D Guth, Michael K Pugsley

J Pharmacol Toxicol Methods· September 2017

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Repeated anaesthesia with isoflurane and medetomidine-midazolam-fentanyl in guinea pigs and its influence on physiological parameters.
Sabrina Schmitz, Sabine Tacke, Brian Guth, Julia Henke

PLoS One· August 2017

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Successful implantation of an abdominal aortic blood pressure transducer and radio-telemetry transmitter in guinea pigs - Anaesthesia, analgesic management and surgical methods, and their influence on hemodynamic parameters and body temperature.
Sabrina Schmitz, Julia Henke, Sabine Tacke, Brian Guth

J Pharmacol Toxicol Methods· May 2017

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Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection.
Georg Rast, Udo Kraushaar, Sandra Buckenmaier, Carina Ittrich, Brian D Guth

J Pharmacol Toxicol Methods· May 2017

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Cardiovascular safety pharmacology studies in dogs enabled for a poorly soluble molecule using spray-dried dispersion: Impact on lead selection.
Yin-Chao Tseng, Brian Linehan, Khing Jow Ng, Dustin M Smith, Michael Markert, Brian Guth

Int J Pharm· October 2016

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Comparison of Physiological Parameters and Anaesthesia Specific Observations during Isoflurane, Ketamine-Xylazine or Medetomidine-Midazolam-Fentanyl Anaesthesia in Male Guinea Pigs.
Sabrina Schmitz, Sabine Tacke, Brian Guth, Julia Henke

PLoS One· September 2016

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The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium.
Brian D Guth, Alan Y Chiang, Jennifer Doyle, Michael J Engwall, Jean-Michel Guillon

J Pharmacol Toxicol Methods· July 2016

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An integrated platform for simultaneous multi-well field potential recording and Fura-2-based calcium transient ratiometry in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes.
Georg Rast, Jürgen Weber, Christoph Disch, Elmar Schuck, Carina Ittrich, Brian D Guth

J Pharmacol Toxicol Methods· July 2016

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Considerations for assessing the potential effects of antidiabetes drugs on cardiac ventricular repolarization: A report from the Cardiac Safety Research Consortium.
Simon Heller, Börje Darpö, Malcolm I Mitchell, Helle Linnebjerg, Derek J Leishman, Brian D Guth

Am Heart J· July 2015

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Influence of repeated anaesthesia on physiological parameters in male Wistar rats: a telemetric study about isoflurane, ketamine-xylazine and a combination of medetomidine, midazolam and fentanyl.
Maike Albrecht, Julia Henke, Sabine Tacke, Michael Markert, Brian Guth

BMC Vet Res· December 2014

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