Publications by authors named "Brian Ladle"

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Towards directed therapy for fusion-positive rhabdomyosarcoma.
George M Turco, Sapna Oberoi, Brian Ladle, Raavi, Lars Wagner

Pharmacol Ther· December 2025

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A therapeutic peptide vaccine for fibrolamellar hepatocellular carcinoma: a phase 1 trial.
Marina Baretti, Allison M Kirk, Brian H Ladle, Zeal Kamdar, Kayla J Bendinelli

Nat Med· December 2025

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Future Directions and Priorities for Cellular Therapy in Sarcoma: A Report from the Strategic Advances in Sarcoma Science Cell Therapy Breakout.
Jacqueline Oliva-Ramirez, David Milewski, Lauren Banks, Kelly M Bailey, Everett J Moding, Brian H Ladle

Cancers (Basel)· September 2025

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Adults and Adolescents With Neuroblastoma: An Analysis of the National Cancer Database.
Charbel Chidiac, Katherine M McDermott, Caitlyn Ramdat, Matthew D Price, Jonathan B Greer, Brian H Ladle

J Surg Oncol· June 2025

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Multidimensional Immunotyping of Human NF1-Associated Peripheral Nerve Sheath Tumors Uncovers Tumor-Associated Macrophages as Key Drivers of Immune Evasion in the Tumor Microenvironment.
Lindy Zhang, Alexandre Maalouf, Stavriani C Makri, Jineta Banerjee, Aditya Suru, Brian H Ladle

Clin Cancer Res· December 2024

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Brain Metastasis in Pediatric Patients with Osteosarcoma.
Jacob Murphy, R Taylor Sundby, Erin E Resch, Ruyan Rahnama, Kathryn M Lemberg, Brian H Ladle

Curr Oncol· November 2024

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Impact of Consolidative Radiation on Overall and Progression-Free Survival in Pediatric, Adolescent, and Young Adult Metastatic Bone and Soft Tissue Sarcoma.
Leslie Chang, Anjali D'Amiano, Rohini Bhatia, Gayane Yenokyan, Nicolas J Llosa, Brian H Ladle

Int J Radiat Oncol Biol Phys· February 2024

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Atezolizumab for Advanced Alveolar Soft Part Sarcoma.
Alice P Chen, Elad Sharon, Geraldine O'Sullivan-Coyne, Nancy Moore, Jared C Foster, Brian H Ladle

N Engl J Med· September 2023

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Gut colonization with an obesity-associated enteropathogenic microbe modulates the premetastatic niches to promote breast cancer lung and liver metastasis.
Sheetal Parida, Sumit Siddharth, Himavanth R Gatla, Shaoguang Wu, Guannan Wang, Brian H Ladle

Front Immunol· July 2023

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Complex/cryptic Gene Fusions and 1q Jumping Translocation in Pediatric Ewing Sarcomas.
Ying S Zou, Laura Morsberger, Melanie Hardy, Jen Ghabrial, Victoria Stinnett, Brian H Ladle

Genes (Basel)· May 2023

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Adoptive Cellular Therapy for Pediatric Solid Tumors: Beyond Chimeric Antigen Receptor-T Cell Therapy.
Jonathan Hensel, Jonathan Metts, Ajay Gupta, Brian H Ladle, Shari Pilon-Thomas

Cancer J· July 2022

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Exceptional response to the ALK and ROS1 inhibitor lorlatinib and subsequent mechanism of resistance in relapsed F1174L-mutated neuroblastoma.
Tingting Liu, Matthew D Merguerian, Steven P Rowe, Christine A Pratilas, Allen R Chen, Brian H Ladle

Cold Spring Harb Mol Case Stud· August 2021

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Pathways of immune exclusion in metastatic osteosarcoma are associated with inferior patient outcomes.
John A Ligon, Woonyoung Choi, Gady Cojocaru, Wei Fu, Emily Han-Chung Hsiue, Brian Ladle

J Immunother Cancer· May 2021

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Predictors of Recurrence and Patterns of Initial Failure in Localized Ewing Sarcoma: A Contemporary 20-Year Experience.
Gregory C Stachelek, John A Ligon, Jennifer Vogel, Adam S Levin, Nicolas J Llosa, Brian H Ladle

Sarcoma· April 2021

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Moving Toward the Ideal Autologous Adoptive T-cell Therapy for Cancer.
Brian H Ladle

Cancer Res· April 2021

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The Immunosuppressive Niche of Soft-Tissue Sarcomas is Sustained by Tumor-Associated Macrophages and Characterized by Intratumoral Tertiary Lymphoid Structures.
Lingling Chen, Teniola Oke, Nicholas Siegel, Gady Cojocaru, Ada J Tam, Brian H Ladle

Clin Cancer Res· August 2020

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Neoantigen-based EpiGVAX vaccine initiates antitumor immunity in colorectal cancer.
Victoria M Kim, Xingyi Pan, Kevin C Soares, Nilofer S Azad, Nita Ahuja, Brian H Ladle

JCI Insight· May 2020

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T-cell receptor signal strength and epigenetic control of Bim predict memory CD8 T-cell fate.
Kun-Po Li, Brian H Ladle, Sema Kurtulus, Allyson Sholl, Sharmila Shanmuganad

Cell Death Differ· April 2020

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De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation.
Brian H Ladle, Kun-Po Li, Maggie J Phillips, Alexandra B Pucsek, Azeb Haile

Proc Natl Acad Sci U S A· September 2016

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De novo DNA methylation is required to restrict T helper lineage plasticity.
Rajan M Thomas, Christopher J Gamper, Brian H Ladle, Jonathan D Powell, Andrew D Wells

J Biol Chem· June 2012

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CD8⁺ Foxp3⁺ tumor infiltrating lymphocytes accumulate in the context of an effective anti-tumor response.
Dung T Le, Brian H Ladle, Timothy Lee, Vivian Weiss, Xiaosai Yao

Int J Cancer· August 2011

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OX40 costimulation synergizes with GM-CSF whole-cell vaccination to overcome established CD8+ T cell tolerance to an endogenous tumor antigen.
Satoshi Murata, Brian H Ladle, Peter S Kim, Eric R Lutz, Matthew E Wolpoe

J Immunol· January 2006

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Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response.
Anne M Ercolini, Brian H Ladle, Elizabeth A Manning, Lukas W Pfannenstiel, Todd D Armstrong

J Exp Med· May 2005

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