Publications by authors named "Brian M Mathes"

Claim this Profile
S
Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug-Drug Interaction Risk Profile.
Junliang Hao, James Beck, Xin Zhou, Gregory L Lackner, Richard Johnston, Brian M Mathes

J Med Chem· March 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor.
David L McKinzie, Leonard L Winneroski, Steven J Green, Erik J Hembre, Jon A Erickson, Brian M Mathes

J Med Chem· June 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Defining Target Engagement Required for Efficacy at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt).
Charles W Lugar, Christian A Clarke, Richard Morphy, Helene Rudyk, Selma Sapmaz, Brian M Mathes

J Med Chem· May 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints.
Leonard L Winneroski, Jon A Erickson, Steven J Green, Jose E Lopez, Stephanie L Stout, Brian M Mathes

Bioorg Med Chem· January 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT₁ F receptor agonists: Evolution from bicyclic to monocyclic cores.
Deyi Zhang, Maria-Jesus Blanco, Bai-Ping Ying, Daniel Kohlman, Sidney X Liang, Brian M Mathes

Bioorg Med Chem Lett· October 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Preparation and biological evaluation of conformationally constrained BACE1 inhibitors.
Leonard L Winneroski, Matthew A Schiffler, Jon A Erickson, Patrick C May, Scott A Monk, Brian M Mathes

Bioorg Med Chem· July 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans.
Patrick C May, Brian A Willis, Stephen L Lowe, Robert A Dean, Scott A Monk, Brian M Mathes

J Neurosci· January 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models.
Jose A Martinez-Perez, Smriti Iyengar, Harlan E Shannon, David Bleakman, Andrew Alt, Brian M Mathes

Bioorg Med Chem Lett· December 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy.
Jose A Martinez-Perez, Smriti Iyengar, Harlan E Shannon, David Bleakman, Andrew Alt, Brian M Mathes

Bioorg Med Chem Lett· December 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor.
Patrick C May, Robert A Dean, Stephen L Lowe, Ferenc Martenyi, Scott M Sheehan, Brian M Mathes

J Neurosci· November 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.
Esteban Dominguez, Smriti Iyengar, Harlan E Shannon, David Bleakman, Andrew Alt, Brian M Mathes

J Med Chem· June 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Substituted furo[3,2-b]pyridines: novel bioisosteres of 5-HT 1F receptor agonists.
Brian M Mathes, Kevin J Hudziak, John M Schaus, Yao-Chang Xu, David L Nelson

Bioorg Med Chem Lett· January 2004

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel potent 5-HT(1F) receptor agonists: structure-activity studies of a series of substituted N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides.
Sandra A Filla, Brian M Mathes, Kirk W Johnson, Lee A Phebus, Marlene L Cohen

J Med Chem· July 2003

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.
Sandra A Filla, Mark A Winter, Kirk W Johnson, David Bleakman, Michael G Bell, Brian M Mathes

J Med Chem· September 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis