Publications by authors named "Bruce A Posner"

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Identification of BET inhibitors (BETi) against solitary fibrous tumor (SFT) through high-throughput screening (HTS).
Jose L Mondaza-Hernandez, David S Moura, Yi Li, Jesus L Marti, Paulino Gomez-Puertas, Bruce A Posner

Neoplasia· December 2025

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Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells.
Sushama Sivakumar, Yihan Wang, Sean C Goetsch, Vrushali Pandit, Lei Wang, Bruce A Posner

Stem Cell Reports· December 2025

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Comprehensive perturbation of transcription factors in human cardiomyocytes reveals the regulatory architecture of congenital heart disease.
Chikara Takeuchi, Sushama Sivakumar, Anjana Sundarrajan, Yihan Wang, Sean C Goetsch, Bruce A Posner

bioRxiv· December 2025

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Identification of α-Azacyclic Acetamide-Based Inhibitors of Na Pump (ATP4) with Fast-Killing Asexual Blood-Stage Antimalarial Activity by Phenotypic Screening.
Arturo Casas, Leah S Imlay, Vandana Thathy, Kate J Fairhurst, Adele M Lehane, Bruce A Posner

ACS Infect Dis· October 2025

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Select Azo Compounds Post-translationally Modulate HTRA1 Abundance and Activity Potentially through Interactions at the Trimer Interface.
John D Hulleman, Seungje Jeon, Sofia Bali, Sophia M DiCesare, Ali Abbas, Bruce A Posner

ACS Chem Biol· August 2025

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Synergistic and antagonistic drug interactions are prevalent but not conserved across acute myeloid leukemia cell lines.
Fatma Neslihan Kalkan, Muhammed Sadik Yildiz, N Ezgi Wood, Michael Farid, Melissa McCoy, Bruce A Posner

Sci Rep· June 2025

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Select azo compounds post-translationally modulate HTRA1 abundance and activity potentially through interactions at the trimer interface.
John D Hulleman, Seungje Jeon, Sofia Bali, Sophia M DiCesare, Ali Abbas, Bruce A Posner

bioRxiv· May 2025

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Identification of α-azacyclic acetamide-based inhibitors of Na pump ( ATP4) with fast-killing asexual blood-stage antimalarial activity by phenotypic screening.
Arturo Casas, Leah S Imlay, Vandana Thathy, Kate J Fairhurst, Adele M Lehane, Bruce A Posner

bioRxiv· May 2025

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Identification of BET Inhibitors (BETi) Against Solitary Fibrous Tumor (SFT) Through High-Throughput Screening (HTS).
Jose L Mondaza-Hernandez, David S Moura, Yi Li, Jesus Lopez-Marti, Paulino Gomez-Puertas, Bruce A Posner

bioRxiv· March 2025

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Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells.
Sushama Sivakumar, Yihan Wang, Sean C Goetsch, Vrushali Pandit, Lei Wang, Bruce A Posner

bioRxiv· January 2025

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Synthesis of the 5/5-spiroindimicin alkaloids: development of a general synthetic approach and biological investigations.
Ankush Banerjee, Tiffany A Brisco, Sneha Ray, Arani Datta, Xiaoyu Zhang, Bruce A Posner

Org Biomol Chem· December 2024

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GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology.
Sophia M DiCesare, Antonio J Ortega, Gracen E Collier, Steffi Daniel, Krista N Thompson, Bruce A Posner

JCI Insight· August 2024

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Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency.
Rachel Tesla, Charlotte Guhl, Gordon C Werthmann, Danielle Dixon, Basar Cenik, Bruce A Posner

Nat Commun· July 2024

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A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells.
Shimeng Xu, Jared C Smothers, Daphne Rye, Shreya Endapally, Hong Chen, Bruce A Posner

Proc Natl Acad Sci U S A· February 2024

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GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology.
Sophia M DiCesare, Antonio J Ortega, Gracen E Collier, Steffi Daniel, Krista N Thompson, Bruce A Posner

bioRxiv· December 2023

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Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.
Thu P Nguyen, Min Fang, Jiwoong Kim, Baiyun Wang, Elisa Lin, Bruce A Posner

Cell Chem Biol· November 2023

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Small molecule glucagon release inhibitors with activity in human islets.
Michael A Kalwat, Karina Rodrigues-Dos-Santos, Derk D Binns, Shuguang Wei, Anwu Zhou, Bruce A Posner

Front Endocrinol (Lausanne)· May 2023

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Fast-Killing Tyrosine Amide (()-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (CARL).
Leah S Imlay, Aloysus K Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Bruce A Posner

ACS Infect Dis· March 2023

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Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.
Thu P Nguyen, Min Fang, Jiwoong Kim, Baiyun Wang, Elisa Lin, Bruce A Posner

bioRxiv· February 2023

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Targeting ESR1 mutation-induced transcriptional addiction in breast cancer with BET inhibition.
Sm N Udden, Qian Wang, Sunil Kumar, Venkat S Malladi, Shwu-Yuan Wu, Bruce A Posner

JCI Insight· September 2022

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Small Molecule-mediated Insulin Hypersecretion Induces Transient ER Stress Response and Loss of Beta Cell Function.
Karina Rodrigues-Dos-Santos, Gitanjali Roy, Derk D Binns, Magdalena G Grzemska, Luiz F Barella, Bruce A Posner

Endocrinology· July 2022

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Total synthesis of (+)-spiroindimicin A and congeners unveils their antiparasitic activity.
Zhen Zhang, Sneha Ray, Leah Imlay, Lauren T Callaghan, Hanspeter Niederstrasser, Bruce A Posner

Chem Sci· August 2021

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Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics.
Somayeh Layeghi-Ghalehsoukhteh, Shreoshi Pal Choudhuri, Ozhan Ocal, Yalda Zolghadri, Victor Pashkov, Bruce A Posner

Sci Rep· November 2020

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The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP-importin α interactions.
Hunmin Jung, Tomomi Takeshima, Tsutomu Nakagawa, Karen S MacMillan, R Max Wynn, Bruce A Posner

Biochem J· September 2020

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Simultaneous Control of Endogenous and User-Defined Genetic Pathways Using Unique ecDHFR Pharmacological Chaperones.
Prerana Ramadurgum, DaNae R Woodard, Steffi Daniel, Hui Peng, Prema L Mallipeddi, Bruce A Posner

Cell Chem Biol· May 2020

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