Publications by authors named "Bruce Clurman"

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Subtype-Specific Dependencies and Drug Vulnerabilities Enable Precision Therapeutics in Head and Neck Cancer.
Joel Vaz, Songli Zhu, Mateo Useche, Lauren Shih, Emily Marchiano, Bruce E Clurman

bioRxiv· December 2025

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Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations.
H Nayanga Thirimanne, Feinan Wu, Derek H Janssens, Jherek Swanger, Ahmed Diab, Bruce E Clurman

Elife· February 2022

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Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor.
Markus Welcker, Baiyun Wang, Domniţa-Valeria Rusnac, Yasser Hussaini, Jherek Swanger, Bruce E Clurman

Sci Adv· January 2022

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Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12.
Omar M Khan, Jorge Almagro, Jessica K Nelson, Stuart Horswell, Vesela Encheva, Bruce E Clurman

Nat Commun· April 2021

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FOXM1 drives HPV+ HNSCC sensitivity to WEE1 inhibition.
Ahmed Diab, Hakan Gem, Jherek Swanger, Hee Yeon Kim, Kaleb Smith, Bruce E Clurman

Proc Natl Acad Sci U S A· November 2020

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A novel landscape of nuclear human CDK2 substrates revealed by in situ phosphorylation.
Yong Chi, John H Carter, Jherek Swanger, Alexander V Mazin, Robert L Moritz, Bruce E Clurman

Sci Adv· April 2020

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Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice.
Keith R Loeb, Bridget T Hughes, Brian M Fissel, Nyka J Osteen, Sue E Knoblaugh, Bruce E Clurman

Sci Rep· April 2019

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Merkel cell polyomavirus Tumor antigens expressed in Merkel cell carcinoma function independently of the ubiquitin ligases Fbw7 and β-TrCP.
Kristine N Dye, Markus Welcker, Bruce E Clurman, Ann Roman, Denise A Galloway

PLoS Pathog· January 2019

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Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism.
Ryan J Davis, Mehmet Gönen, Daciana H Margineantu, Shlomo Handeli, Jherek Swanger, Bruce E Clurman

Proc Natl Acad Sci U S A· May 2018

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RAD54 N-terminal domain is a DNA sensor that couples ATP hydrolysis with branch migration of Holliday junctions.
Nadish Goyal, Matthew J Rossi, Olga M Mazina, Yong Chi, Robert L Moritz, Bruce E Clurman

Nat Commun· January 2018

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The miR-106a~363 miRNA cluster induces murine T cell lymphoma despite transcriptional activation of the p27 cell cycle inhibitor.
Daniel A Kuppers, Thomas M Schmitt, Harry C Hwang, Lavanya Samraj, Bruce E Clurman

Oncotarget· August 2017

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The PP2A-B56 Phosphatase Opposes Cyclin E Autocatalytic Degradation via Site-Specific Dephosphorylation.
Ryan J Davis, Jherek Swanger, Bridget T Hughes, Bruce E Clurman

Mol Cell Biol· April 2017

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DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing.
Philamer C Calses, Kiranjit K Dhillon, Nyka Tucker, Yong Chi, Jen-Wei Huang, Bruce E Clurman

Cell Rep· April 2017

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NUP50 is necessary for the survival of primordial germ cells in mouse embryos.
Eunsook Park, Bobae Lee, Bruce E Clurman, Keesook Lee

Reproduction· January 2016

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Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells.
Chad M Toledo, Yu Ding, Pia Hoellerbauer, Ryan J Davis, Ryan Basom, Bruce E Clurman

Cell Rep· December 2015

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Oncoprotein ubiquitylation: dimers, degrons, and degradation.
Markus Welcker, Bruce E Clurman

Cell Cycle· January 2015

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Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy.
Hui Zhao, Claire M Faltermeier, Lori Mendelsohn, Peggy L Porter, Bruce E Clurman

Oncotarget· December 2014

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Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.
Ryan J Davis, Markus Welcker, Bruce E Clurman

Cancer Cell· October 2014

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Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions.
Rocio Sancho, Sophia M Blake, Christian Tendeng, Bruce E Clurman, Julian Lewis

PLoS Biol· January 2014

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Fbw7 dimerization determines the specificity and robustness of substrate degradation.
Markus Welcker, Elizabeth A Larimore, Jherek Swanger, Maria T Bengoechea-Alonso, Jonathan E Grim, Bruce E Clurman

Genes Dev· December 2013

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Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation.
Bridget T Hughes, Julia Sidorova, Jherek Swanger, Raymond J Monnat, Bruce E Clurman

Proc Natl Acad Sci U S A· May 2013

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Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.
Bin Zhang, Chris Gaiteri, Liviu-Gabriel Bodea, Zhi Wang, Joshua McElwee, Bruce Clurman

Cell· April 2013

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Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.
Nathan W Pierce, J Eugene Lee, Xing Liu, Michael J Sweredoski, Robert L J Graham, Bruce E Clurman

Cell· March 2013

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Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase.
Asli A Hizli, Yong Chi, Jherek Swanger, John H Carter, Yi Liao, Bruce E Clurman

Mol Cell Biol· February 2013

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The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.
Michael A Davis, Elizabeth A Larimore, Brian M Fissel, Jherek Swanger, Dylan J Taatjes, Bruce E Clurman

Genes Dev· January 2013

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