Publications by authors named "Bruce Malcolm"

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Effect of constant versus variable small-group facilitators on students' basic science knowledge in an enquiry-based dental curriculum.
Daniel Zahra, Jon Bennett, Louise Belfield, Kamran Ali, Clare Mcilwaine, Malcolm Bruce

Eur J Dent Educ· November 2019

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PrEP-001 prophylactic effect against rhinovirus and influenza virus - RESULTS of 2 randomized trials.
Bruce Albert Malcolm, Caroline Anne Aerts, Kristof Johan Dubois, Frederik Joris Geurts, Kris Marien

Antiviral Res· May 2018

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Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.
Daniela A Braun, Jia Rao, Geraldine Mollet, David Schapiro, Marie-Claire Daugeron, Malcolm Bruce

Nat Genet· October 2017

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Half-life extension of the HIV-fusion inhibitor peptide TRI-1144 using a novel linker technology.
Eric L Schneider, Gary W Ashley, Lieve Dillen, Bart Stoops, Nigel E Austin, Bruce A Malcolm

Eur J Pharm Biopharm· June 2015

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Improving dental experiences by using virtual reality distraction: a simulation study.
Karin Tanja-Dijkstra, Sabine Pahl, Mathew P White, Jackie Andrade, Cheng Qian, Malcolm Bruce

PLoS One· May 2015

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The glycosylation of AGP and its associations with the binding to methadone.
Jennifer L Behan, Yvonne E Cruickshank, Gerri Matthews-Smith, Malcolm Bruce, Kevin D Smith

Biomed Res Int· March 2014

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Can virtual nature improve patient experiences and memories of dental treatment? A study protocol for a randomized controlled trial.
Karin Tanja-Dijkstra, Sabine Pahl, Mathew P White, Jackie Andrade, Jon May, Malcolm Bruce

Trials· March 2014

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A case of γ-butyrolactone associated with severe withdrawal delirium and acute renal failure.
Indrani S Bhattacharya, Fiona Watson, Malcolm Bruce

Eur Addict Res· May 2012

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Screening and rank ordering of reversible mechanism-based inhibitors of hepatitis C virus NS3 protease using electrospray ionization mass spectrometry.
Yan-Hui Liu, Lata Ramanathan, Bruce Malcolm, George Njoroge, Tin-Yau Chan

J Mass Spectrom· August 2011

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A comparative analysis of the substrate permissiveness of HCV and GBV-B NS3/4A proteases reveals genetic evidence for an interaction with NS4B protein during genome replication.
Yann Benureau, Lucile Warter, Bruce A Malcolm, Annette Martin

Virology· October 2010

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Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor.
Ashok Arasappan, Frank Bennett, Stephane L Bogen, Srikanth Venkatraman, Melissa Blackman, Bruce Malcolm

ACS Med Chem Lett· May 2010

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Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034.
Vincent Madison, Andrew J Prongay, Zhuyan Guo, Nanhua Yao, John Pichardo, Bruce Malcolm

J Synchrotron Radiat· May 2008

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Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.
Andrew J Prongay, Zhuyan Guo, Nanhua Yao, John Pichardo, Thierry Fischmann, Bruce Malcolm

J Med Chem· May 2007

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Addressing the efficacy of dihydrocodeine versus methadone as an alternative maintenance treatment for opiate dependence: A randomized controlled trial.
J Roy Robertson, Gillian M Raab, Malcolm Bruce, James S McKenzie, Helen R Storkey

Addiction· December 2006

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Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection.
Srikanth Venkatraman, Stéphane L Bogen, Ashok Arasappan, Frank Bennett, Kevin Chen, Bruce Malcolm

J Med Chem· October 2006

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Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034.
Xiao Tong, Robert Chase, Angela Skelton, Tong Chen, Jackie Wright-Minogue, Bruce A Malcolm

Antiviral Res· June 2006

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Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations.
MinKyung Yi, Xiao Tong, Angela Skelton, Robert Chase, Tong Chen, Bruce A Malcolm

J Biol Chem· March 2006

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Trans-complementation of HCV replication by non-structural protein 5A.
Xiao Tong, Bruce A Malcolm

Virus Res· February 2006

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Impact of naturally occurring variants of HCV protease on the binding of different classes of protease inhibitors.
Xiao Tong, Zhuyan Guo, Jacquelyn Wright-Minogue, Ellen Xia, Andrew Prongay, Bruce A Malcolm

Biochemistry· February 2006

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Development of a fluorescence polarization bead-based coupled assay to target different activity/conformation states of a protein kinase.
Zhuomei Lu, Zhizhang Yin, Linda James, Rosalinda Syto, Jill M Stafford, Bruce Malcolm

J Biomol Screen· June 2004

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A continuous nonradioactive assay for RNA-dependent RNA polymerase activity.
Frederick C Lahser, Bruce A Malcolm

Anal Biochem· February 2004

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Conserved C-terminal threonine of hepatitis C virus NS3 regulates autoproteolysis and prevents product inhibition.
Wenyan Wang, Frederick C Lahser, MinKyung Yi, Jacquelyn Wright-Minogue, Ellen Xia, Bruce A Malcolm

J Virol· January 2004

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The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA.
Sifang Zhou, Rong Liu, Bahige M Baroudy, Bruce A Malcolm, Gregory R Reyes

Virology· June 2003

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Dosage of treatment to sexual offenders: are we overprescribing?
Donna L Mailloux, Jeffrey Abracen, Ralph Serin, C Cousineau, Bruce Malcolm

Int J Offender Ther Comp Criminol· April 2003

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Quantitative estimation of viral fitness using Pyrosequencing.
Frederick C Lahser, Jacquelyn Wright-Minogue, Angela Skelton, Bruce A Malcolm

Biotechniques· January 2003

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