Publications by authors named "Vincent Madison"

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Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor.
Yongqi Deng, Gerald W Shipps, Lianyun Zhao, M Arshad Siddiqui, Janeta Popovici-Muller, Vincent S Madison

Bioorg Med Chem Lett· January 2014

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Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: a template-based approach--part 2.
Marc Labroli, Kamil Paruch, Michael P Dwyer, Carmen Alvarez, Kartik Keertikar, Vincent Madison

Bioorg Med Chem Lett· January 2011

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Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: a template-based approach--part 1.
Michael P Dwyer, Kamil Paruch, Marc Labroli, Carmen Alvarez, Kerry M Keertikar, Vincent Madison

Bioorg Med Chem Lett· January 2011

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Novel TNF-α converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases.
Vinay M Girijavallabhan, Lei Chen, Chaoyang Dai, Robert J Feltz, Luke Firmansjah, Vincent Madison

Bioorg Med Chem Lett· December 2010

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Structure and activity relationships of tartrate-based TACE inhibitors.
Dansu Li, Janeta Popovici-Muller, David B Belanger, John Caldwell, Chaoyang Dai, Vincent Madison

Bioorg Med Chem Lett· August 2010

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Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases.
Kamil Paruch, Michael P Dwyer, Carmen Alvarez, Courtney Brown, Tin-Yau Chan, Vincent Madison

ACS Med Chem Lett· August 2010

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Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor.
Ashok Arasappan, Frank Bennett, Stephane L Bogen, Srikanth Venkatraman, Melissa Blackman, Vincent Madison

ACS Med Chem Lett· May 2010

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Potent ketoamide inhibitors of HCV NS3 protease derived from quaternized P1 groups.
Srikanth Venkatraman, Francisco Velazquez, Wanli Wu, Melissa Blackman, Vincent Madison

Bioorg Med Chem Lett· April 2010

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Discovery and SAR of hydantoin TACE inhibitors.
Wensheng Yu, Zhuyan Guo, Peter Orth, Vincent Madison, Lei Chen

Bioorg Med Chem Lett· March 2010

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The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors.
Kristin E Rosner, Zhuyan Guo, Peter Orth, Gerald W Shipps, David B Belanger, Vincent Madison

Bioorg Med Chem Lett· February 2010

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Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.
Yu-Sen Wang, Corey Strickland, Johannes H Voigt, Matthew E Kennedy, Brian M Beyer, Vincent S Madison

J Med Chem· February 2010

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Semi-synthetic aristolactams--inhibitors of CDK2 enzyme.
Vinod R Hegde, Scott Borges, Haiyan Pu, Mahesh Patel, Vincent P Gullo, Vincent Madison

Bioorg Med Chem Lett· February 2010

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Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors.
Thierry O Fischmann, Catherine K Smith, Todd W Mayhood, Joseph E Myers, Paul Reichert, Vincent S Madison

Biochemistry· March 2009

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Discovery of novel spirocyclopropyl hydroxamate and carboxylate compounds as TACE inhibitors.
Zhuyan Guo, Peter Orth, Shing-Chun Wong, Brian J Lavey, Neng-Yang Shih, Vincent Madison

Bioorg Med Chem Lett· January 2009

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Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket.
Robert D Mazzola, Zhaoning Zhu, Lisa Sinning, Brian McKittrick, Brian Lavey, Vincent Madison

Bioorg Med Chem Lett· November 2008

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Induced-fit docking of mometasone furoate and further evidence for glucocorticoid receptor 17alpha pocket flexibility.
Hongwu Wang, Robert Aslanian, Vincent S Madison

J Mol Graph Model· November 2008

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Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody.
Brian M Beyer, Richard Ingram, Lata Ramanathan, Paul Reichert, Hung V Le, Vincent Madison

J Mol Biol· October 2008

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Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability.
Wenyan Wang, Winifred W Prosise, Jun Chen, S Shane Taremi, Hung V Le, Vincent Madison

Protein Eng Des Sel· July 2008

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Structure-guided discovery of cyclin-dependent kinase inhibitors.
Thierry O Fischmann, Alan Hruza, José S Duca, Lata Ramanathan, Todd Mayhood, Vincent Madison

Biopolymers· May 2008

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Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034.
Vincent Madison, Andrew J Prongay, Zhuyan Guo, Nanhua Yao, John Pichardo

J Synchrotron Radiat· May 2008

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Identification of novel cannabinoid CB1 receptor antagonists by using virtual screening with a pharmacophore model.
Hongwu Wang, Ruth A Duffy, George C Boykow, Samuel Chackalamannil, Vincent S Madison

J Med Chem· April 2008

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Cross-docking of inhibitors into CDK2 structures. 1.
José S Duca, Vincent S Madison, Johannes H Voigt

J Chem Inf Model· March 2008

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Cross-docking of inhibitors into CDK2 structures. 2.
Johannes H Voigt, Carl Elkin, Vincent S Madison, José S Duca

J Chem Inf Model· March 2008

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Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors: Part I--discovery of two binding modes.
Zhaoning Zhu, Robert Mazzola, Lisa Sinning, Brian McKittrick, Xiaoda Niu, Vincent Madison

J Med Chem· February 2008

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Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2.
Kamil Paruch, Michael P Dwyer, Carmen Alvarez, Courtney Brown, Tin-Yau Chan, Vincent Madison

Bioorg Med Chem Lett· November 2007

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