Publications by authors named "Bryan Roth"

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Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors.
Michael Bram Kuijer, Camryn J Fulton, Talia L Albert, Paloma Knobloch, Jing Wang, Bryan L Roth

Biochemistry· December 2025

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Nanobody-drug conjugates for targeting specific GPCR pairs.
Xianglin Huang, Bryan L Roth

PLoS Biol· November 2025

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ZEBRA: Z Stitch and Early Bedrest Study, a multicenter randomized clinical trial.
Adarsh Katamreddy, Sanket Gokhale, Francis T Phan, Ryle Przybylowicz, Jose Lozano Garcia, Bryan Roth

Heart Rhythm· November 2025

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The polypharmacology of psychedelics reveals multiple targets for potential therapeutics.
Manish K Jain, Ryan H Gumpper, Samuel T Slocum, Gavin P Schmitz, Jakob S Madsen, Bryan L Roth

Neuron· October 2025

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Psychedelic compounds directly excite 5-HT layer V medial prefrontal cortex neurons through 5-HT Gq activation.
Gavin P Schmitz, Yi-Ting Chiu, Mia L Foglesong, Sarah N Magee, Martin MacKinnon, Bryan L Roth

Transl Psychiatry· October 2025

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Differential effects of sodium on agonist-induced conformational transitions and signaling at μ and κ opioid receptors.
Bram Kuijer, Camryn J Fulton, Talia L Albert, Paloma M Knobloch, Jing Wang, Bryan L Roth

bioRxiv· September 2025

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Orchestrating NTSR1 signaling from the interface.
Xianglin Huang, Brian E Krumm, Bryan L Roth

Cell Res· June 2025

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design of miniprotein agonists and antagonists targeting G protein-coupled receptors.
Edin Muratspahić, David Feldman, David E Kim, Xiangli Qu, Ana-Maria Bratovianu, Bryan L Roth

bioRxiv· June 2025

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Chemogenetics for sensing antigens.
Blake A Fordyce, Bryan L Roth

Cell Res· May 2025

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Intracellular GPCR modulators enable precision pharmacology.
Brian E Krumm, Bryan L Roth

NPJ Drug Discov· May 2025

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The structural diversity of psychedelic drug actions revealed.
Ryan H Gumpper, Manish K Jain, Kuglae Kim, Renhong Sun, Ning Sun, Bryan L Roth

Nat Commun· March 2025

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Selective Mu-Opioid Receptor Imaging Using F-Labeled Carfentanils.
So Jeong Lee, Torben D Pearson, Maeva Dhaynaut, Alexander C MacDonagh, Hsiao-Ying Wey, Bryan L Roth

J Med Chem· January 2025

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High-affinity agonists reveal recognition motifs for the MRGPRD GPCR.
Chunyu Wang, Yongfeng Liu, Marion Lanier, Adam Yeager, Isha Singh, Bryan L Roth

Cell Rep· December 2024

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Structure-guided design of a peripherally restricted chemogenetic system.
Hye Jin Kang, Brian E Krumm, Adrien Tassou, Matan Geron, Jeffrey F DiBerto, Bryan L Roth

Cell· December 2024

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Molecular glues as potential GPCR therapeutics.
Bryan L Roth, Brian E Krumm

Biochem Pharmacol· October 2024

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Piecing together aminergic polypharmacology.
Blake A Fordyce, Bryan L Roth

Cell Res· September 2024

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A proximity proteomics pipeline with improved reproducibility and throughput.
Xiaofang Zhong, Qiongyu Li, Benjamin J Polacco, Trupti Patil, Aaron Marley, Bryan L Roth

Mol Syst Biol· August 2024

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A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.
Kevin M Knight, Brian E Krumm, Nicholas J Kapolka, W Grant Ludlam, Meng Cui, Bryan L Roth

Nat Commun· August 2024

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AlphaFold2 structures guide prospective ligand discovery.
Jiankun Lyu, Nicholas Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Bryan L Roth

Science· June 2024

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Author Correction: Bitter taste receptor activation by cholesterol and an intracellular tastant.
Yoojoong Kim, Ryan H Gumpper, Yongfeng Liu, D Dewran Kocak, Yan Xiong, Bryan L Roth

Nature· June 2024

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Xylazine is an agonist at kappa opioid receptors and exhibits sex-specific responses to opioid antagonism.
Madigan L Bedard, Xi-Ping Huang, Jackson G Murray, Alexandra C Nowlan, Sara Y Conley, Bryan L Roth

Addict Neurosci· June 2024

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MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model.
Daphne Chun-Che Chien, Nathachit Limjunyawong, Can Cao, James Meixiong, Qi Peng, Bryan L Roth

Sci Transl Med· May 2024

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An shRNA screen in primary human beta cells identifies the serotonin 1F receptor as a negative regulator of survival during transplant.
Rebecca A Lee, Deeksha G Chopra, Vinh Nguyen, Xi-Ping Huang, Yaohuan Zhang, Bryan Roth

bioRxiv· May 2024

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Virtual Screening of a Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target.
Katharina Grotsch, Anastasiia V Sadybekov, Sydney Hiller, Saheem Zaidi, Dmitry Eremin, Bryan L Roth

ACS Chem Biol· April 2024

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Bitter taste receptor activation by cholesterol and an intracellular tastant.
Yoojoong Kim, Ryan H Gumpper, Yongfeng Liu, D Dewran Kocak, Yan Xiong, Bryan L Roth

Nature· April 2024

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