Publications by authors named "Cameron Pye"

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DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2-p53 Inhibitor.
Anthony P Silvestri, Qi Zhang, Yan Ping, Erik W Muir, Jingsi Zhao, Cameron R Pye

ACS Med Chem Lett· June 2023

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Getting bifunctional molecules into cells.
R Scott Lokey, Cameron Pye

Science· December 2022

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NP Analyst: An Open Online Platform for Compound Activity Mapping.
Sanghoon Lee, Jeffrey A van Santen, Nima Farzaneh, Dennis Y Liu, Cameron R Pye

ACS Cent Sci· February 2022

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Geometrically Diverse Lariat Peptide Scaffolds Reveal an Untapped Chemical Space of High Membrane Permeability.
Colin N Kelly, Chad E Townsend, Ajay N Jain, Matthew R Naylor, Cameron R Pye

J Am Chem Soc· January 2021

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Drug-Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side-Chain Lipophilicity.
Akihiro Furukawa, Joshua Schwochert, Cameron R Pye, Daigo Asano, Quinn D Edmondson

Angew Chem Int Ed Engl· November 2020

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Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility.
Matthew R Naylor, Andrew M Ly, Mason J Handford, Daniel P Ramos, Cameron R Pye

J Med Chem· December 2018

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CycLS: Accurate, whole-library sequencing of cyclic peptides using tandem mass spectrometry.
Chad Townsend, Akihiro Furukawa, Joshua Schwochert, Cameron R Pye, Quinn Edmondson

Bioorg Med Chem· March 2018

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Reply to Skinnider and Magarvey: Rates of novel natural product discovery remain high.
Cameron R Pye, Matthew J Bertin, R Scott Lokey, William H Gerwick, Roger G Linington

Proc Natl Acad Sci U S A· August 2017

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Retrospective analysis of natural products provides insights for future discovery trends.
Cameron R Pye, Matthew J Bertin, R Scott Lokey, William H Gerwick, Roger G Linington

Proc Natl Acad Sci U S A· May 2017

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Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules.
Cameron R Pye, William M Hewitt, Joshua Schwochert, Terra D Haddad, Chad E Townsend

J Med Chem· March 2017

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Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry.
Akihiro Furukawa, Chad E Townsend, Joshua Schwochert, Cameron R Pye, Maria A Bednarek

J Med Chem· October 2016

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Stereochemistry Balances Cell Permeability and Solubility in the Naturally Derived Phepropeptin Cyclic Peptides.
Joshua Schwochert, Yongtong Lao, Cameron R Pye, Matthew R Naylor, Prashant V Desai

ACS Med Chem Lett· August 2016

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A Strategy for Direct Chemical Activation of the Retinoblastoma Protein.
Cameron R Pye, Walter M Bray, Elise R Brown, Jason R Burke, R Scott Lokey

ACS Chem Biol· May 2016

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Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues.
Andrew T Bockus, Joshua A Schwochert, Cameron R Pye, Chad E Townsend, Vong Sok

J Med Chem· September 2015

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Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products.
Andrew T Bockus, Katrina W Lexa, Cameron R Pye, Amit S Kalgutkar, Jarret W Gardner

J Med Chem· June 2015

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Cell-permeable cyclic peptides from synthetic libraries inspired by natural products.
William M Hewitt, Siegfried S F Leung, Cameron R Pye, Alexandra R Ponkey, Maria Bednarek

J Am Chem Soc· January 2015

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Revisiting N-to-O acyl shift for synthesis of natural product-like cyclic depsipeptides.
Joshua Schwochert, Cameron Pye, Christopher Ahlbach, Yashar Abdollahian, Kathleen Farley

Org Lett· December 2014

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The functional group on (E)-4,4'-disubstituted stilbenes influences toxicity and antioxidative activity in differentiated PC-12 cells.
Genevieve X Garcia, Sean W Larsen, Cameron Pye, Michael Galbreath, Ralph Isovitsch

Bioorg Med Chem Lett· December 2013

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