Publications by authors named "Chad Townsend"

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Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides.
Yuki Hosono, Satoshi Uchida, Moe Shinkai, Chad E Townsend, Colin N Kelly

Nat Commun· March 2023

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Cyclosporin A: Conformational Complexity and Chameleonicity.
Satoshi Ono, Matthew R Naylor, Chad E Townsend, Chieko Okumura, Okimasa Okada

J Chem Inf Model· November 2021

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Geometrically Diverse Lariat Peptide Scaffolds Reveal an Untapped Chemical Space of High Membrane Permeability.
Colin N Kelly, Chad E Townsend, Ajay N Jain, Matthew R Naylor, Cameron R Pye

J Am Chem Soc· January 2021

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Connecting the conformational behavior of cyclic octadepsipeptides with their ionophoric property and membrane permeability.
Thomas Stadelmann, Govindan Subramanian, Sanjay Menon, Chad E Townsend, R Scott Lokey

Org Biomol Chem· September 2020

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Understanding and Improving the Membrane Permeability of VH032-Based PROTACs.
Victoria G Klein, Chad E Townsend, Andrea Testa, Michael Zengerle, Chiara Maniaci

ACS Med Chem Lett· September 2020

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Conformation and Permeability: Cyclic Hexapeptide Diastereomers.
Satoshi Ono, Matthew R Naylor, Chad E Townsend, Chieko Okumura, Okimasa Okada

J Chem Inf Model· June 2019

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Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility.
Matthew R Naylor, Andrew M Ly, Mason J Handford, Daniel P Ramos, Cameron R Pye, Chad E Townsend

J Med Chem· December 2018

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CycLS: Accurate, whole-library sequencing of cyclic peptides using tandem mass spectrometry.
Chad Townsend, Akihiro Furukawa, Joshua Schwochert, Cameron R Pye, Quinn Edmondson

Bioorg Med Chem· March 2018

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Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules.
Cameron R Pye, William M Hewitt, Joshua Schwochert, Terra D Haddad, Chad E Townsend

J Med Chem· March 2017

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Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry.
Akihiro Furukawa, Chad E Townsend, Joshua Schwochert, Cameron R Pye, Maria A Bednarek

J Med Chem· October 2016

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Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues.
Andrew T Bockus, Joshua A Schwochert, Cameron R Pye, Chad E Townsend, Vong Sok

J Med Chem· September 2015

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