Publications by authors named "Can Kayatekin"

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AAV gene therapy for GBA1-related diseases.
Swathi Ayloo, Jae Cheon Ryu, Shih-Ching Chou, Lydia Blatnik, Erik Wischhof, Can Kayatekin

Mol Ther· December 2025

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Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophy.
Jeremy Y Huang, Brian Freed, Martin Hanus, Kelly Keefe, Ming Sum Ruby Chiang, Can Kayatekin

iScience· September 2025

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A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies.
Sungwon An, John J McInnis, Dongin Kim, Yihang Li, Ozge Tasdemir-Yilmaz, Can Kayatekin

NPJ Parkinsons Dis· August 2025

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The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.
Erinc Hallacli, Can Kayatekin, Sumaiya Nazeen, Xiou H Wang, Zoe Sheinkopf

Cell· June 2022

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Evaluation of Neurofilament Light Chain as a Biomarker of Neurodegeneration in X-Linked Childhood Cerebral Adrenoleukodystrophy.
Hongge Wang, Matthew D Davison, Martin L Kramer, Weiliang Qiu, Tatiana Gladysheva, Can Kayatekin

Cells· March 2022

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Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA-related synucleinopathy model.
Catherine Viel, Jennifer Clarke, Can Kayatekin, Amy M Richards, Ming Sum R Chiang

Sci Rep· October 2021

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Murine Models of Lysosomal Storage Diseases Exhibit Differences in Brain Protein Aggregation and Neuroinflammation.
Jennifer Clarke, Can Kayatekin, Catherine Viel, Lamya Shihabuddin, Sergio Pablo Sardi

Biomedicines· April 2021

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Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition.
Peter Tsvetkov, Timothy J Eisen, Sven U Heinrich, Zarina Brune, Erinc Hallacli, Can Kayatekin

Cell Rep· September 2020

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Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition.
Peter Tsvetkov, Timothy J Eisen, Sven U Heinrich, Zarina Brune, Erinc Hallacli, Can Kayatekin

Cell Rep· August 2020

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Friction-Limited Folding of Disulfide-Reduced Monomeric SOD1.
Noah R Cohen, Can Kayatekin, Jill A Zitzewitz, Osman Bilsel, C R Matthews

Biophys J· April 2020

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Microbial specialization by prions.
Gregory A Newby, Can Kayatekin

Prion· July 2018

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Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity.
Can Kayatekin, Audra Amasino, Giorgio Gaglia, Jason Flannick, Julia M Bonner

Cell· March 2018

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A Genetic Tool to Track Protein Aggregates and Control Prion Inheritance.
Gregory A Newby, Szilvia Kiriakov, Erinc Hallacli, Can Kayatekin, Peter Tsvetkov

Cell· November 2017

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Luminidependens (LD) is an Arabidopsis protein with prion behavior.
Sohini Chakrabortee, Can Kayatekin, Greg A Newby, Marc L Mendillo, Alex Lancaster

Proc Natl Acad Sci U S A· May 2016

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Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1.
Can Kayatekin, Kent E S Matlack, William R Hesse, Yinghua Guan, Sohini Chakrabortee

Proc Natl Acad Sci U S A· August 2014

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Microsecond barrier-limited chain collapse observed by time-resolved FRET and SAXS.
Sagar V Kathuria, Can Kayatekin, Raul Barrea, Elena Kondrashkina, Rita Graceffa

J Mol Biol· May 2014

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Distinct prion strains are defined by amyloid core structure and chaperone binding site dynamics.
Kendra K Frederick, Galia T Debelouchina, Can Kayatekin, Tea Dorminy, Angela C Jacavone

Chem Biol· February 2014

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Identification of human monoclonal antibodies specific for human SOD1 recognizing distinct epitopes and forms of SOD1.
Teresa J Broering, Hongyan Wang, Naomi K Boatright, Yang Wang, Katherine Baptista, Can Kayatekin

PLoS One· November 2013

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Isolation, characterization, and aggregation of a structured bacterial matrix precursor.
Liraz Chai, Diego Romero, Can Kayatekin, Barak Akabayov, Hera Vlamakis

J Biol Chem· June 2013

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Enthalpic barriers dominate the folding and unfolding of the human Cu, Zn superoxide dismutase monomer.
Can Kayatekin, Noah R Cohen, C Robert Matthews

J Mol Biol· December 2012

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Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
Mikko Taipale, Irina Krykbaeva, Martina Koeva, Can Kayatekin, Kenneth D Westover

Cell· August 2012

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Disulfide-reduced ALS variants of Cu, Zn superoxide dismutase exhibit increased populations of unfolded species.
Can Kayatekin, Jill A Zitzewitz, C Robert Matthews

J Mol Biol· April 2010

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Metal-free ALS variants of dimeric human Cu,Zn-superoxide dismutase have enhanced populations of monomeric species.
Anna-Karin E Svensson, Osman Bilsel, Can Kayatekin, Jessica A Adefusika, Jill A Zitzewitz

PLoS One· April 2010

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Zinc binding modulates the entire folding free energy surface of human Cu,Zn superoxide dismutase.
Can Kayatekin, Jill A Zitzewitz, C Robert Matthews

J Mol Biol· December 2008

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Microsecond acquisition of heterogeneous structure in the folding of a TIM barrel protein.
Ying Wu, Elena Kondrashkina, Can Kayatekin, C Robert Matthews, Osman Bilsel

Proc Natl Acad Sci U S A· September 2008

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