Publications by authors named "Carl D Davis"

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Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists.
Stephen E Mercer, Prasad V Chaturvedula, Charles M Conway, Deborah A Cook, Carl D Davis

Bioorg Med Chem Lett· January 2021

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Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine.
Daniel B Horne, Kaustav Biswas, James Brown, Michael D Bartberger, Jeffrey Clarine, Carl D Davis

J Med Chem· September 2018

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Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression.
Andrew P Degnan, George O Tora, Hong Huang, David A Conlon, Carl D Davis

ACS Chem Neurosci· December 2016

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Biaryls as potent, tunable dual neurokinin 1 receptor antagonists and serotonin transporter inhibitors.
Andrew P Degnan, George O Tora, Ying Han, Ramkumar Rajamani, Robert Bertekap, Carl D Davis

Bioorg Med Chem Lett· August 2015

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Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient receptor potential melastatin 8 (TRPM8) antagonists.
Daniel B Horne, Nuria A Tamayo, Michael D Bartberger, Yunxin Bo, Jeffrey Clarine, Carl D Davis

J Med Chem· April 2014

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Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain.
Yong-Jin Wu, Charles M Conway, Li-Qiang Sun, Frederic Machet, Jie Chen, Carl D Davis

Bioorg Med Chem Lett· November 2013

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NK1 receptor antagonism lowers occupancy requirement for antidepressant-like effects of SSRIs in the gerbil forced swim test.
Snjezana Lelas, Yu-Wen Li, Tanya L Wallace-Boone, Matthew T Taber, Amy E Newton, Carl D Davis

Neuropharmacology· October 2013

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Preparation of imidazoles as potent calcitonin gene-related peptide (CGRP) antagonists.
George Tora, Andrew P Degnan, Charles M Conway, Walter A Kostich, Carl D Davis

Bioorg Med Chem Lett· October 2013

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The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2.
Xiaojun Han, Rita L Civiello, Charles M Conway, Deborah A Cook, Carl D Davis

Bioorg Med Chem Lett· March 2013

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The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1.
Xiaojun Han, Rita L Civiello, Charles M Conway, Deborah A Cook, Carl D Davis

Bioorg Med Chem Lett· July 2012

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The tortuous road to an ideal CGRP function blocker for the treatment of migraine.
Carl D Davis, Cen Xu

Curr Top Med Chem· December 2008

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Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure.
Andrew P Degnan, Prasad V Chaturvedula, Charles M Conway, Deborah A Cook, Carl D Davis

J Med Chem· August 2008

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Cytochrome P450 reaction-phenotyping: an industrial perspective.
Hongjian Zhang, Carl D Davis, Michael W Sinz, A David Rodrigues

Expert Opin Drug Metab Toxicol· October 2007

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Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar.
Donglu Zhang, Lifei Wang, Gamini Chandrasena, Li Ma, Mingshe Zhu, Carl D Davis

Drug Metab Dispos· January 2007

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Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent inhibition.
Yong-Jin Wu, Carl D Davis, Steven Dworetzky, William C Fitzpatrick, David Harden

J Med Chem· August 2003

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