Publications by authors named "Carl Decicco"

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Discovery of FHD-286, a First-in-Class, Orally Bioavailable, Allosteric Dual Inhibitor of the Brahma Homologue (BRM) and Brahma-Related Gene 1 (BRG1) ATPase Activity for the Treatment of SWItch/Sucrose Non-Fermentable (SWI/SNF) Dependent Cancers.
Rishi G Vaswani, David S Huang, Neville Anthony, Lan Xu, Richard Centore, Carl Decicco

J Med Chem· January 2025

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Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker.
James R Corte, Tianan Fang, Honey Osuna, Donald J P Pinto, Karen A Rossi, Carl P Decicco

J Med Chem· February 2017

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Correction to "Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development".
Scott A Shaw, Balu Balasubramanian, Samuel Bonacorsi, Janet Caceres Cortes, Kevin Cao, Carl Decicco

J Org Chem· September 2015

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Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development.
Scott A Shaw, Balu Balasubramanian, Samuel Bonacorsi, Janet Caceres Cortes, Kevin Cao, Carl Decicco

J Org Chem· July 2015

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Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists.
Robert J Cherney, Ruowei Mo, Michael G Yang, Zili Xiao, Qihong Zhao, Carl P Decicco

Bioorg Med Chem Lett· April 2014

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Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.
Robert J Cherney, Ruowei Mo, Dayton T Meyer, Anthony D Pechulis, Michael A Guaciaro, Carl P Decicco

Bioorg Med Chem Lett· October 2012

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Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone.
Percy H Carter, Gregory D Brown, Sarah R King, Matthew E Voss, Andrew J Tebben, Carl P Decicco

Bioorg Med Chem Lett· May 2012

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Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.
Lorin A Thompson, Jianliang Shi, Carl P Decicco, Andrew J Tebben, Richard E Olson

Bioorg Med Chem Lett· November 2011

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Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor.
Kevin W Gillman, John E Starrett, Michael F Parker, Kai Xie, Joanne J Bronson, Carl P Decicco

ACS Med Chem Lett· June 2010

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gamma-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.
Robert J Cherney, Ruowei Mo, Dayton T Meyer, Matthew E Voss, Michael G Yang, Carl P Decicco

Bioorg Med Chem Lett· April 2010

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Novel sulfone-containing di- and trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists.
Robert J Cherney, Ruowei Mo, Dayton T Meyer, Matthew E Voss, Yvonne C Lo, Carl P Decicco

Bioorg Med Chem Lett· July 2009

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Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists.
Robert J Cherney, John B Brogan, Ruowei Mo, Yvonne C Lo, Gengjie Yang, Carl P Decicco

Bioorg Med Chem Lett· February 2009

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Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists.
Robert J Cherney, David J Nelson, Yvonne C Lo, Gengjie Yang, Peggy A Scherle, Carl P Decicco

Bioorg Med Chem Lett· September 2008

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N-in-1 dosing pharmacokinetics in drug discovery: experience, theoretical and practical considerations.
Kan He, Mingxin Qian, Harvey Wong, Stephen A Bai, Bing He, Carl P Decicco

J Pharm Sci· July 2008

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Role of P-glycoprotein and the intestine in the excretion of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in rodents.
C Edwin Garner, Eric Solon, Chii-Ming Lai, Jianrong Lin, Gang Luo, Carl P Decicco

Drug Metab Dispos· June 2008

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Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists.
Robert J Cherney, Ruowei Mo, Dayton T Meyer, David J Nelson, Yvonne C Lo, Carl P Decicco

J Med Chem· February 2008

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Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors.
James J-W Duan, Lihua Chen, Zhonghui Lu, Chu-Biao Xue, Rui-Qin Liu, Carl P Decicco

Bioorg Med Chem Lett· January 2008

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Alpha,beta-cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE).
Gregory R Ott, Naoyuki Asakawa, Zhonghui Lu, Rui-Qin Liu, Maryanne B Covington, Carl P Decicco

Bioorg Med Chem Lett· January 2008

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From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis.
Joseph B Santella, Daniel S Gardner, Wenqing Yao, Chongsheng Shi, Prabhakar Reddy, Carl P Decicco

Bioorg Med Chem Lett· January 2008

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Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans.
Mingxin Qian, Stephen A Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Carl P Decicco

Drug Metab Dispos· October 2007

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Capped diaminopropionamide-glycine dipeptides are inhibitors of CC chemokine receptor 2 (CCR2).
Percy H Carter, Gregory D Brown, Sarah R Friedrich, Robert J Cherney, Andrew J Tebben, Carl P Decicco

Bioorg Med Chem Lett· October 2007

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Effect of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a human tumor necrosis factor alpha-converting enzyme inhibitor, on the disposition of methotrexate: a transporter-based drug-drug interaction case study.
Gang Luo, C Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E Richards, Carl P Decicco

Drug Metab Dispos· June 2007

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CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.
James R Pruitt, Douglas G Batt, Dean A Wacker, Lori L Bostrom, Shon K Booker, Carl P Decicco

Bioorg Med Chem Lett· June 2007

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Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
James E Sheppeck, John L Gilmore, Andrew Tebben, Chu-Biao Xue, Rui-Qin Liu, Carl P Decicco

Bioorg Med Chem Lett· May 2007

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Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe.
Percy H Carter, Rui-Qin Liu, William R Foster, Joseph A Tamasi, Andrew J Tebben, Carl P Decicco

Proc Natl Acad Sci U S A· April 2007

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