Publications by authors named "Chad Zimprich"

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Protomer selectivity of type II RAF inhibitors within the RAS/RAF complex.
James D Vasta, Ani Michaud, Chad A Zimprich, Michael T Beck, Matthew R Swiatnicki

Cell Chem Biol· November 2023

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Small-molecule inhibition of the archetypal UbiB protein COQ8.
Nathan H Murray, Christopher R M Asquith, Zixiang Fang, Michael P East, Naomi Ptak, Chad A Zimprich

Nat Chem Biol· February 2023

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KRAS is vulnerable to reversible switch-II pocket engagement in cells.
James D Vasta, D Matthew Peacock, Qinheng Zheng, Joel A Walker, Ziyang Zhang, Chad A Zimprich

Nat Chem Biol· June 2022

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Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model.
Sida Shen, Cristina Picci, Kseniya Ustinova, Veronick Benoy, Zsófia Kutil, Chad A Zimprich

J Med Chem· April 2021

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NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay.
Andrea Peier, Lan Ge, Nicolas Boyer, John Frost, Ruchia Duggal, Chad Zimprich

ACS Chem Biol· February 2021

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Quantifying CDK inhibitor selectivity in live cells.
Carrow I Wells, James D Vasta, Cesear R Corona, Jennifer Wilkinson, Chad A Zimprich

Nat Commun· June 2020

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Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models.
Sida Shen, Melissa Hadley, Kseniya Ustinova, Jiri Pavlicek, Tessa Knox, Chad A Zimprich

J Med Chem· September 2019

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Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome.
Alan P Kozikowski, Sida Shen, Marta Pardo, Maurício T Tavares, Dora Szarics, Chad A Zimprich

ACS Chem Neurosci· March 2019

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Detection of Experimental and Clinical Immune Complexes by Measuring SHIP-1 Recruitment to the Inhibitory FcγRIIB.
Richard J Stopforth, Robert J Oldham, Alison L Tutt, Patrick Duriez, H T Claude Chan, Chad Zimprich

J Immunol· March 2018

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Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement.
James D Vasta, Cesear R Corona, Jennifer Wilkinson, Chad A Zimprich, James R Hartnett

Cell Chem Biol· February 2018

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Highly Potent Cell-Permeable and Impermeable NanoLuc Luciferase Inhibitors.
Joel R Walker, Mary P Hall, Chad A Zimprich, Matthew B Robers, Sarah J Duellman

ACS Chem Biol· April 2017

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Homogeneous plate based antibody internalization assay using pH sensor fluorescent dye.
Nidhi Nath, Becky Godat, Chad Zimprich, Stephen J Dwight, Cesear Corona

J Immunol Methods· April 2016

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Target engagement and drug residence time can be observed in living cells with BRET.
Matthew B Robers, Melanie L Dart, Carolyn C Woodroofe, Chad A Zimprich, Thomas A Kirkland

Nat Commun· December 2015

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A luminescent assay for real-time measurements of receptor endocytosis in living cells.
Matthew B Robers, Brock F Binkowski, Mei Cong, Chad Zimprich, Cesear Corona

Anal Biochem· November 2015

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In vivo tracking of human neural progenitor cells in the rat brain using bioluminescence imaging.
Ksenija Bernau, Christina M Lewis, Anna M Petelinsek, Hélène A Benink, Chad A Zimprich

J Neurosci Methods· May 2014

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Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model.
Dan Krakora, Patrick Mulcrone, Michael Meyer, Christina Lewis, Ksenija Bernau, Chad Zimprich

Mol Ther· August 2013

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Development of a dehalogenase-based protein fusion tag capable of rapid, selective and covalent attachment to customizable ligands.
Lance P Encell, Rachel Friedman Ohana, Kris Zimmerman, Paul Otto, Gediminas Vidugiris, Chad Zimprich

Curr Chem Genomics· December 2012

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HaloTag: a novel protein labeling technology for cell imaging and protein analysis.
Georgyi V Los, Lance P Encell, Mark G McDougall, Danette D Hartzell, Natasha Karassina, Chad Zimprich

ACS Chem Biol· June 2008

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Spatial separation and bidirectional trafficking of proteins using a multi-functional reporter.
Soshana Svendsen, Chad Zimprich, Mark G McDougall, Dieter H Klaubert, Georgyi V Los

BMC Cell Biol· April 2008

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