Publications by authors named "Ching Ching Leow"

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Pirtobrutinib Versus Ibrutinib in Treatment-Naïve and Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.
Jennifer A Woyach, Lugui Qiu, Sebastian Grosicki, Tomasz Wrobel, Marcelo Capra, Ching Ching Leow

J Clin Oncol· December 2025

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Reply to: Optimizing Control Arms in Chronic Lymphocytic Leukemia Clinical Trials: The BRUIN-CLL-321 Trial.
Jeff P Sharman, Bin Liu, Denise Y Wang, Ching Ching Leow, Paul M Barr

J Clin Oncol· November 2025

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Erratum: Phase III Trial of Pirtobrutinib Versus Idelalisib/Rituximab or Bendamustine/Rituximab in Covalent Bruton Tyrosine Kinase Inhibitor-Pretreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN CLL-321).
Jeff P Sharman, Talha Munir, Sebastian Grosicki, Lindsey E Roeker, John M Burke, Ching Ching Leow

J Clin Oncol· September 2025

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Phase III Trial of Pirtobrutinib Versus Idelalisib/Rituximab or Bendamustine/Rituximab in Covalent Bruton Tyrosine Kinase Inhibitor-Pretreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN CLL-321).
Jeff P Sharman, Talha Munir, Sebastian Grosicki, Lindsey E Roeker, John M Burke, Ching Ching Leow

J Clin Oncol· August 2025

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Erratum: Phase III Trial of Pirtobrutinib Versus Idelalisib/Rituximab or Bendamustine/Rituximab in Covalent Bruton Tyrosine Kinase Inhibitor-Pretreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN CLL-321).
Jeff P Sharman, Talha Munir, Sebastian Grosicki, Lindsey E Roeker, John M Burke, Ching Ching Leow

J Clin Oncol· August 2025

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Safety and Immunogenicity of LY3415244, a Bispecific Antibody Against TIM-3 and PD-L1, in Patients With Advanced Solid Tumors.
Matthew D Hellmann, Nicoletta Bivi, Boris Calderon, Toshio Shimizu, Brant Delafontaine, Ching Ching Leow

Clin Cancer Res· May 2021

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Blocking TIM-3 in Treatment-refractory Advanced Solid Tumors: A Phase Ia/b Study of LY3321367 with or without an Anti-PD-L1 Antibody.
James J Harding, Victor Moreno, Yung-Jue Bang, Min Hee Hong, Amita Patnaik, Ching Ching Leow

Clin Cancer Res· April 2021

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GITR ligand fusion protein agonist enhances the tumor antigen-specific CD8 T-cell response and leads to long-lasting memory.
Nick M Durham, Nick Holoweckyj, Randall S MacGill, Kelly McGlinchey, Ching Ching Leow

J Immunother Cancer· April 2018

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Insertion of scFv into the hinge domain of full-length IgG1 monoclonal antibody results in tetravalent bispecific molecule with robust properties.
Binyam Bezabeh, Ryan Fleming, Christine Fazenbaker, Haihong Zhong, Karen Coffman, Ching Ching Leow

MAbs· November 2017

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A Novel Murine GITR Ligand Fusion Protein Induces Antitumor Activity as a Monotherapy That Is Further Enhanced in Combination with an OX40 Agonist.
Rebecca Leyland, Amanda Watkins, Kathy A Mulgrew, Nicholas Holoweckyj, Lisa Bamber, Ching Ching Leow

Clin Cancer Res· July 2017

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Targeting CD73 in the tumor microenvironment with MEDI9447.
Carl M Hay, Erin Sult, Qihui Huang, Kathy Mulgrew, Stacy R Fuhrmann, Ching Ching Leow

Oncoimmunology· August 2016

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Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages.
Teresa E Peterson, Nathaniel D Kirkpatrick, Yuhui Huang, Christian T Farrar, Koen A Marijt, Ching Ching Leow

Proc Natl Acad Sci U S A· April 2016

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Doxil synergizes with cancer immunotherapies to enhance antitumor responses in syngeneic mouse models.
Jonathan Rios-Doria, Nicholas Durham, Leslie Wetzel, Raymond Rothstein, Jon Chesebrough, Ching Ching Leow

Neoplasia· August 2015

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A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways.
Jonathan Rios-Doria, Darrin Sabol, Jon Chesebrough, Dave Stewart, Linda Xu, Ching Ching Leow

Mol Cancer Ther· July 2015

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Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade.
Nicolò Rigamonti, Ece Kadioglu, Ioanna Keklikoglou, Céline Wyser Rmili, Ching Ching Leow

Cell Rep· August 2014

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Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions.
Wei Zheng, Harri Nurmi, Sila Appak, Amélie Sabine, Esther Bovay, Ching Ching Leow

Genes Dev· July 2014

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Multivalent scaffold proteins as superagonists of TRAIL receptor 2-induced apoptosis.
Jeffery S Swers, Luba Grinberg, Lin Wang, Hui Feng, Kristen Lekstrom, Ching Ching Leow

Mol Cancer Ther· July 2013

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MEDI3617, a human anti-angiopoietin 2 monoclonal antibody, inhibits angiogenesis and tumor growth in human tumor xenograft models.
Ching Ching Leow, Karen Coffman, Ivan Inigo, Shannon Breen, Meggan Czapiga

Int J Oncol· May 2012

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Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis.
Tanja Holopainen, Pipsa Saharinen, Gabriela D'Amico, Anita Lampinen, Lauri Eklund, Ching Ching Leow

J Natl Cancer Inst· March 2012

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Antitumor efficacy of IPI-504, a selective heat shock protein 90 inhibitor against human epidermal growth factor receptor 2-positive human xenograft models as a single agent and in combination with trastuzumab or lapatinib.
Ching Ching Leow, Jon Chesebrough, Karen T Coffman, Christine A Fazenbaker, John Gooya

Mol Cancer Ther· August 2009

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Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway.
Ching Ching Leow, Bu-Er Wang, Jed Ross, Sara M Chan, Jiping Zha

J Biol Chem· July 2009

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HATH1 expression in mucinous cancers of the colorectum and related lesions.
Eun Taek Park, Hee Kyung Oh, James R Gum, Suzanne C Crawley, Sanjay Kakar, Ching Ching Leow

Clin Cancer Res· September 2006

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Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation.
Xi-De Wang, Ching Ching Leow, Jiping Zha, Zhijun Tang, Zora Modrusan

Dev Biol· February 2006

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A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma.
Ching Ching Leow, Paul Polakis, Wei-Qiang Gao

Ann N Y Acad Sci· November 2005

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Novel method of generating prostate-specific Cre-LoxP gene switching via intraductal delivery of adenovirus.
Ching Ching Leow, Xi-De Wang, Wei-Qiang Gao

Prostate· September 2005

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