Publications by authors named "Lauri Eklund"

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Collagen XV preserves heart function and protects from pathological remodelling after myocardial infarction.
Sanna-Maria Karppinen, Miki Aho, Zoltan Szabo, Johanna Magga, Laura Vainio, Lauri Eklund

FEBS J· August 2025

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The glycosaminoglycan chains of perlecan regulate the perivascular fluid transport.
Abhishek Singh, Mika Kaakinen, Harri Elamaa, Vesa Kiviniemi, Lauri Eklund

Fluids Barriers CNS· May 2025

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Microfluidic vessel-on-chip platform for investigation of cellular defects in venous malformations and responses to various shear stress and flow conditions.
Mohammadhassan Ansarizadeh, Hoang-Tuan Nguyen, Bojana Lazovic, Jere Kettunen, Laknee De Silva, Lauri Eklund

Lab Chip· February 2025

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Identification of cell type-specific cell-penetrating peptides through in vivo phage display leveraged by next generation sequencing.
Franziska Kohl, Oliver Laufkötter, Mike Firth, Luc Krimpenfort, Priyanka Mangla, Lauri Eklund

Biomed Pharmacother· January 2025

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Human iPSC and CRISPR targeted gene knock-in strategy for studying the somatic TIE2 mutation in endothelial cells.
Bojana Lazovic, Hoang-Tuan Nguyen, Mohammadhassan Ansarizadeh, Leif Wigge, Franziska Kohl, Lauri Eklund

Angiogenesis· August 2024

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Correction: Human iPSC and CRISPR targeted gene knock-in strategy for studying the somatic TIE2L914F mutation in endothelial cells.
Bojana Lazovic, Hoang-Tuan Nguyen, Mohammadhassan Ansarizadeh, Leif Wigge, Franziska Kohl, Lauri Eklund

Angiogenesis· August 2024

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Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy.
Ibrahim Sultan, Markus Ramste, Pim Peletier, Karthik Amudhala Hemanthakumar, Deepak Ramanujam, Lauri Eklund

Circ Res· May 2024

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Loss-of-function mutations of the TIE1 receptor tyrosine kinase cause late-onset primary lymphedema.
Pascal Brouillard, Aino Murtomäki, Veli-Matti Leppänen, Marko Hyytiäinen, Sandrine Mestre, Lauri Eklund

J Clin Invest· May 2024

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Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer's disease-related amyloid pathology.
Salli Antila, Dmitri Chilov, Harri Nurmi, Zhilin Li, Anni Näsi, Lauri Eklund

Nat Cardiovasc Res· April 2024

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Synchronous functional magnetic resonance eye imaging, video ophthalmoscopy, and eye surface imaging reveal the human brain and eye pulsation mechanisms.
Seyed-Mohsen Ebrahimi, Johanna Tuunanen, Ville Saarela, Marja Honkamo, Niko Huotari, Lauri Eklund

Sci Rep· January 2024

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Blood pressure lowering enhances cerebrospinal fluid efflux to the systemic circulation primarily via the lymphatic vasculature.
Jari Jukkola, Mika Kaakinen, Abhishek Singh, Sadegh Moradi, Hany Ferdinando, Lauri Eklund

Fluids Barriers CNS· January 2024

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Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis.
Yi Jin, Yindi Ding, Mark Richards, Mika Kaakinen, Wolfgang Giese, Lauri Eklund

Nat Cardiovasc Res· December 2022

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Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal Maintenance.
Emmi Kapiainen, Harri Elamaa, Ilkka Miinalainen, Valerio Izzi, Lauri Eklund

Invest Ophthalmol Vis Sci· October 2022

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Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression.
Emilia A Korhonen, Aino Murtomäki, Sawan Kumar Jha, Andrey Anisimov, Anne Pink, Lauri Eklund

J Clin Invest· August 2022

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Functional human cell-based vascularised cardiac tissue model for biomedical research and testing.
Maria Koivisto, Tuomas A Tolvanen, Tarja Toimela, Ilkka Miinalainen, Antti Kiviaho, Lauri Eklund

Sci Rep· August 2022

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Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner.
Mark Richards, Emmanuel Nwadozi, Sagnik Pal, Pernilla Martinsson, Mika Kaakinen, Lauri Eklund

Elife· July 2022

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PHD2 deletion in endothelial or arterial smooth muscle cells reveals vascular cell type-specific responses in pulmonary hypertension and fibrosis.
Harri Elamaa, Mika Kaakinen, Marjut Nätynki, Zoltan Szabo, Veli-Pekka Ronkainen, Lauri Eklund

Angiogenesis· May 2022

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Computer extracted gland features from H&E predicts prostate cancer recurrence comparably to a genomic companion diagnostic test: a large multi-site study.
Patrick Leo, Andrew Janowczyk, Robin Elliott, Nafiseh Janaki, Kaustav Bera, Lauri Eklund

NPJ Precis Oncol· May 2021

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The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice.
Emmi Kapiainen, Minna K Kihlström, Riikka Pietilä, Mika Kaakinen, Veli-Pekka Ronkainen, Lauri Eklund

Cancer Res· January 2021

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EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity.
Maike Frye, Simon Stritt, Henrik Ortsäter, Magda Hernandez Vasquez, Mika Kaakinen, Lauri Eklund

Elife· September 2020

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Histopathological evaluation of prostate specimens after thermal ablation may be confounded by the presence of thermally-fixed cells.
Mikael Anttinen, Eemil Yli-Pietilä, Visa Suomi, Pietari Mäkelä, Teija Sainio, Lauri Eklund

Int J Hyperthermia· January 2020

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IMPROD biparametric MRI in men with a clinical suspicion of prostate cancer (IMPROD Trial): Sensitivity for prostate cancer detection in correlation with whole-mount prostatectomy sections and implications for focal therapy.
Harri Merisaari, Ivan Jambor, Otto Ettala, Peter J Boström, Ileana Montoya Perez, Lauri Eklund

J Magn Reson Imaging· November 2019

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Feasibility of MRI-guided transurethral ultrasound for lesion-targeted ablation of prostate cancer.
Mikael Anttinen, Pietari Mäkelä, Visa Suomi, Aida Kiviniemi, Jani Saunavaara, Lauri Eklund

Scand J Urol· October 2019

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Angiopoietin-4-dependent venous maturation and fluid drainage in the peripheral retina.
Harri Elamaa, Minna Kihlström, Emmi Kapiainen, Mika Kaakinen, Ilkka Miinalainen, Lauri Eklund

Elife· November 2018

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Targeting β1-integrin inhibits vascular leakage in endotoxemia.
Laura Hakanpaa, Elina A Kiss, Guillaume Jacquemet, Ilkka Miinalainen, Martina Lerche, Lauri Eklund

Proc Natl Acad Sci U S A· July 2018

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