Publications by authors named "Ching- Ping Chen"

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High-fat diet impairs the dendritic morphology of hippocampal CA1 pyramidal neurons in male but not female mice.
Shu-Fang Teng, Ming Tatt Lee, Li-Jen Lee, Ling-Ling Hwang, Ching-Ping Chen, Chiung-Tong Chen

Front Nutr· December 2025

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Orally Bioavailable and Site-Selective Covalent STING Inhibitor Derived from a Macrocyclic Marine Diterpenoid.
Guang-Hao Niu, Wan-Chi Hsiao, Po-Hsun Lee, Li-Guo Zheng, Yu-Shao Yang, Wei-Cheng Huang, Ching-Ping Chen, Chen-Lung Huang, Chiung-Tong Chen

J Med Chem· March 2025

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Discovery of a Long Half-Life AURKA Inhibitor to Treat MYC-Amplified Solid Tumors as a Monotherapy and in Combination with Everolimus.
Chun-Ping Chang, Teng-Kuang Yeh, Chiung-Tong Chen, Wan-Ping Wang, Yen-Ting Chen, Yan-Fu Chen, Ching-Ping Chen, Chen-Lung Huang, Ya-Ping Chen

Mol Cancer Ther· June 2024

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Development of Furanopyrimidine-Based Orally Active Third-Generation EGFR Inhibitors for the Treatment of Non-Small Cell Lung Cancer.
Mu-Chun Li, Mohane Selvaraj Coumar, Shu-Yu Lin, Yih-Shyan Lin, Guan-Lin Huang, Chun-Hwa Chen, Yen-Ting Chen, Ching-Ping Chen, Yu-Chen Huang, Chen-Ming Yang, Chiung-Tong Chen

J Med Chem· February 2023

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Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization.
Mu-Chun Li, Wen-Hsing Lin, Pei-Chen Wang, Yu-Chieh Su, Pei-Yi Chen, Ching-Ping Chen, Chen-Lung Huang, Chiung-Tong Chen

Eur J Med Chem· November 2021

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Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins.
Ya-Hui Chi, Teng-Kuang Yeh, Yi-Yu Ke, Wen-Hsing Lin, Chia-Hua Tsai, Yen-Ting Chen, Pei-Chen Wang, Yan-Fu Chen, Ching-Ping Chen, Chiung-Tong Chen

J Med Chem· June 2021

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BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy.
Yun-Yu Chen, Chen-Fu Lo, Tai-Yu Chiu, Chia-Yu Hsu, Teng-Kuang Yeh, Ching-Ping Chen, Chen-Lung Huang, Yu-Chen Huang, Chiung-Tong Chen

Transl Oncol· January 2021

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Impacts of Intralipid on Nanodrug Abraxane Therapy and on the Innate Immune System.
Yen-Ju Chen, Chin-Yi Tsai, Ying-Min Cheng, Su-Wen Nieh, Teng-Kuang Yeh, Ching- Ping Chen, Chiung- Tong Chen

Sci Rep· February 2020

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Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia.
Wen-Hsing Lin, Su-Ying Wu, Teng-Kuang Yeh, Chiung-Tong Chen, Jen-Shin Song, Cheng-Tai Lu, Pei-Chen Wang, Ching-Ping Chen, Ching-Cheng Hsueh, Chen-Lung Huang, Li-Tzong Chen

J Med Chem· December 2019

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Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer.
Shu-Yu Lin, Yung Chang Hsu, Yi-Hui Peng, Yi-Yu Ke, Wen-Hsing Lin, Pei-Yi Chen, Chun-Hwa Chen, Ching-Ping Chen, Chiung-Tong Chen

J Med Chem· November 2019

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Transformation of Sexual Expression in Taiwanese Women After Treatment for Gynecological Cancer.
Jian Tao Lee, Helene H Lin, Jia Ling Tsai, Ching-Ping Chen, Kuan-Gen Huang

Cancer Nurs· January 2017

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Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation.
Yung Chang Hsu, Mohane Selvaraj Coumar, Wen-Chieh Wang, Hui-Yi Shiao, Yi-Yu Ke, Pei-Yi Chen, Chun-Hwa Chen, Ching-Ping Chen, Chen-Lung Huang, Chiung-Tong Chen

Oncotarget· December 2016

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Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations.
Chiung-Tong Chen, John T-A Hsu, Wen-Hsing Lin, Cheng-Tai Lu, Shih-Chieh Yen, Chun-Hwa Chen, Ching-Ping Chen, Chen-Lung Huang

Eur J Med Chem· July 2015

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Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer.
Wen-Hsing Lin, Teng-Kuang Yeh, Weir-Torn Jiaang, Kuei-Jung Yen, Chun-Hwa Chen, Ching-Ping Chen, Chiung-Tong Chen

PLoS One· September 2014

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BPR0C305, an orally active microtubule-disrupting anticancer agent.
Wen-Tai Li, Teng-Kuang Yeh, Jen-Shin Song, Yung-Ning Yang, Tung-Wei Chen, Ching-Ping Chen, Chiung-Tong Chen

Anticancer Drugs· November 2013

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Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
Wen-Hsing Lin, John T-A Hsu, Shu-Yi Hsieh, Chiung-Tong Chen, Jen-Shin Song, Cheng-Tai Lu, Chun-Hwa Chen, Ching-Ping Chen

Bioorg Med Chem· June 2013

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Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.
Jiun-Ming Wu, Chiung-Tong Chen, Mohane Selvaraj Coumar, Wen-Hsin Lin, Zi-Jie Chen, Ching-Ping Chen, Ching-Cheng Hsueh

Proc Natl Acad Sci U S A· May 2013

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[Sexual satisfaction and related factors in women previously treated for gynecological cancer].
Ching-Ping Chen, Kuan-Gen Huang, Gwo-Hwa Wan, Li-Yen Tu, Jian-Tao Lee

Hu Li Za Zhi· April 2013

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Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents.
Wen-Tai Li, Der-Ren Hwang, Jen-Shin Song, Ching-Ping Chen, Tung-Wei Chen, Chen-Lung Huang, Chiung-Tong Chen

Invest New Drugs· February 2012

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Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
Wen-Hsing Lin, Shu-Yi Hsieh, Shih-Chieh Yen, Chiung-Tong Chen, Teng-Kuang Yeh, Cheng-Tai Lu, Ching-Ping Chen, Chun-Wha Chen, An-Huei Cheng

Bioorg Med Chem· July 2011

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BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities.
Chih-Bo Hu, Ching-Ping Chen, Teng-Kuang Yeh, Jen-Shin Song, Chi-Yen Chang, Tung-Wei Chen, Chen-Lung Huang, Chiung-Tong Chen

Cancer Sci· January 2011

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Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency.
Chia-Hsien Wu, Mohane Selvaraj Coumar, Chang-Ying Chu, Wen-Hsing Lin, Yi-Rong Chen, Chiung-Tong Chen, Chun-Hwa Chen, Ching-Ping Chen, Chun-Chen Liao

J Med Chem· October 2010

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Intravenous paclitaxel against metastasis of human gastric tumors of diffuse type.
Tsung-Fan Tuan, Meng-Li Tsai, Kai-Chia Yeh, Hsin-Chieh Huang, Cheng-Ta Chung, Chen-Lung Huang, Ching-Ping Chen, Chiung-Tong Chen

Cancer Chemother Pharmacol· September 2010

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Antiangiogenic activities and cisplatin-combined antitumor activities of BPR0L075.
Ching-Ping Chen, Chih-Bo Hu, Kai-Chia Yeh, Jen-Shin Song, Teng-Kuang Yeh, Yu-Chen Huang, Chiung-Tong Chen

Anticancer Res· July 2010

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Synthesis and biological activities of 2-amino-1-arylidenamino imidazoles as orally active anticancer agents.
Wen-Tai Li, Der-Ren Hwang, Jen-Shin Song, Ching-Ping Chen, Jiunn-Jye Chuu, Chen-Lung Huang, Tung-Wei Chen, Chiung-Tong Chen

J Med Chem· March 2010

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