Publications by authors named "Christopher Dempsey"

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Stereoselective block of the hERG potassium channel by the Class Ia antiarrhythmic drug disopyramide.
Yihong Zhang, Aziza El Harchi, Andrew F James, Shigetoshi Oiki, Christopher E Dempsey

Cell Mol Life Sci· November 2024

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Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue.
Matthew V Helliwell, Yihong Zhang, Aziza El Harchi, Christopher E Dempsey, Jules C Hancox

Pharmaceuticals (Basel)· August 2023

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Evolutionary coupling analysis guides identification of mistrafficking-sensitive variants in cardiac K channels: Validation with hERG.
Yihong Zhang, Amy L Grimwood, Jules C Hancox, Stephen C Harmer, Christopher E Dempsey

Front Pharmacol· October 2022

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Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant.
Ehab Al-Moubarak, Holly A Shiels, Yihong Zhang, Chunyun Du, Oliver Hanington, Christopher E Dempsey

Cell Mol Life Sci· December 2021

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Electrophysiological characterization of the modified hERG potassium channel used to obtain the first cryo-EM hERG structure.
Yihong Zhang, Christopher E Dempsey, Jules C Hancox

Physiol Rep· October 2020

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Serine mutation of a conserved threonine in the hERG K channel S6-pore region leads to loss-of-function through trafficking impairment.
Ehab Al-Moubarak, Yihong Zhang, Christopher E Dempsey, Henggui Zhang, Stephen C Harmer

Biochem Biophys Res Commun· June 2020

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The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine.
Aziza El Harchi, Andrew S Butler, Yihong Zhang, Christopher E Dempsey, Jules C Hancox

Physiol Rep· March 2020

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An Update on the Structure of hERG.
Andrew Butler, Matthew V Helliwell, Yihong Zhang, Jules C Hancox, Christopher E Dempsey

Front Pharmacol· January 2020

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Identification of a proton sensor that regulates conductance and open time of single hERG channels.
Stacey L Wilson, Christopher E Dempsey, Jules C Hancox, Neil V Marrion

Sci Rep· December 2019

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Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome.
Hongwei Cheng, Chunyun Du, Yihong Zhang, Andrew F James, Christopher E Dempsey

J Mol Cell Cardiol· October 2019

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Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome.
Andrew Butler, Yihong Zhang, A Graham Stuart, Christopher E Dempsey, Jules C Hancox

Heliyon· April 2019

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Analysis of α-Dystroglycan/LG Domain Binding Modes: Investigating Protein Motifs That Regulate the Affinity of Isolated LG Domains.
Christopher E Dempsey, Maria Giulia Bigotti, Josephine C Adams, Andrea Brancaccio

Front Mol Biosci· March 2019

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Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome.
Andrew Butler, Yihong Zhang, Alan G Stuart, Christopher E Dempsey, Jules C Hancox

Physiol Rep· September 2018

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Structural implications of hERG K channel block by a high-affinity minimally structured blocker.
Matthew V Helliwell, Yihong Zhang, Aziza El Harchi, Chunyun Du, Jules C Hancox, Christopher E Dempsey

J Biol Chem· May 2018

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Reprogramming the Activatable Peptide Display Function of Adeno-Associated Virus Nanoparticles.
Nicole N Thadani, Christopher Dempsey, Julia Zhao, Sonya M Vasquez, Junghae Suh

ACS Nano· February 2018

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The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption.
Manon F Pritchard, Lydia C Powell, Saira Khan, Peter C Griffiths, Omar T Mansour, Christopher E Dempsey

Sci Rep· March 2017

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The Basis for Low-affinity hERG Potassium Channel Block by Sotalol.
Yi Hong Zhang, Christopher E Dempsey, Jules C Hancox

J Pharmacol Pharmacother· January 2017

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Arginine side chain interactions and the role of arginine as a gating charge carrier in voltage sensitive ion channels.
Craig T Armstrong, Philip E Mason, J L Ross Anderson, Christopher E Dempsey

Sci Rep· February 2016

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hERG potassium channel inhibition by ivabradine requires channel gating.
Dario Melgari, Kieran E Brack, Yihong Zhang, Aziza El Harchi, John S Mitcheson, Christopher E Dempsey

J Mol Cell Cardiol· October 2015

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Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide.
Dario Melgari, Yihong Zhang, Aziza El Harchi, Christopher E Dempsey, Jules C Hancox

J Mol Cell Cardiol· September 2015

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hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes.
Jules C Hancox, Dario Melgari, Christopher E Dempsey, Kieran E Brack, John Mitcheson

Ther Adv Drug Saf· August 2015

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hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine.
Dario Melgari, Kieran E Brack, Chuan Zhang, Yihong Zhang, Aziza El Harchi, Christopher E Dempsey

J Am Heart Assoc· April 2015

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Voltage sensor gating charge transfer in a hERG potassium channel model.
Charlotte K Colenso, Yang Cao, Richard B Sessions, Jules C Hancox, Christopher E Dempsey

Biophys J· November 2014

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Ranolazine inhibition of hERG potassium channels: drug-pore interactions and reduced potency against inactivation mutants.
Chunyun Du, Yihong Zhang, Aziza El Harchi, Christopher E Dempsey, Jules C Hancox

J Mol Cell Cardiol· September 2014

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Tunable protease-activatable virus nanonodes.
Justin Judd, Michelle L Ho, Abhinav Tiwari, Eric J Gomez, Christopher Dempsey

ACS Nano· May 2014

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