Publications by authors named "John Mitcheson"

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Correction: Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel.
Mark J Burton, Joel Cresser-Brown, Morgan Thomas, Nicola Portolano, Jaswir Basran, John S Mitcheson

J Biol Chem· March 2022

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Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel.
Mark J Burton, Joel Cresser-Brown, Morgan Thomas, Nicola Portolano, Jaswir Basran, John S Mitcheson

J Biol Chem· September 2020

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Author Correction: A mechanism for CO regulation of ion channels.
Sofia M Kapetanaki, Mark J Burton, Jaswir Basran, Chiasa Uragami, Peter C E Moody, John S Mitcheson

Nat Commun· August 2018

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A Novel Mechanism for Calmodulin-Dependent Inactivation of Transient Receptor Potential Vanilloid 6.
Neil Bate, Rachel E Caves, Simon P Skinner, Benjamin T Goult, Jaswir Basran, John S Mitcheson

Biochemistry· May 2018

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A mechanism for CO regulation of ion channels.
Sofia M Kapetanaki, Mark J Burton, Jaswir Basran, Chiasa Uragami, Peter C E Moody, John S Mitcheson

Nat Commun· March 2018

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Modulation of hERG potassium channels by a novel small molecule activator.
John S Mitcheson, Jules C Hancox

Br J Pharmacol· October 2017

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Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain.
Eva Lörinczi, Matthew Helliwell, Alina Finch, Phillip J Stansfeld, Noel W Davies, John S Mitcheson

J Biol Chem· August 2016

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A heme-binding domain controls regulation of ATP-dependent potassium channels.
Mark J Burton, Sofia M Kapetanaki, Tatyana Chernova, Andrew G Jamieson, Pierre Dorlet, John S Mitcheson

Proc Natl Acad Sci U S A· April 2016

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hERG potassium channel inhibition by ivabradine requires channel gating.
Dario Melgari, Kieran E Brack, Yihong Zhang, Aziza El Harchi, John S Mitcheson

J Mol Cell Cardiol· October 2015

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hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes.
Jules C Hancox, Dario Melgari, Christopher E Dempsey, Kieran E Brack, John Mitcheson

Ther Adv Drug Saf· August 2015

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hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine.
Dario Melgari, Kieran E Brack, Chuan Zhang, Yihong Zhang, Aziza El Harchi, John S Mitcheson

J Am Heart Assoc· April 2015

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New pyrimido-indole compound CD-160130 preferentially inhibits the KV11.1B isoform and produces antileukemic effects without cardiotoxicity.
Luca Gasparoli, Massimo D'Amico, Marika Masselli, Serena Pillozzi, Rachel Caves, John S Mitcheson

Mol Pharmacol· February 2015

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Long-term channel block is required to inhibit cellular transformation by human ether-à-go-go-related gene (hERG1) potassium channels.
David M Pier, George S G Shehatou, Susan Giblett, Christine E Pullar, Derek J Trezise, John S Mitcheson

Mol Pharmacol· August 2014

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Computational design and discovery of "minimally structured" hERG blockers.
Andrea Cavalli, Rosa Buonfiglio, Cristina Ianni, Matteo Masetti, Luisa Ceccarini, John S Mitcheson

J Med Chem· April 2012

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Resonance assignment and secondary structure prediction of the N-terminal domain of hERG (Kv11.1).
Frederick W Muskett, John S Mitcheson

Biomol NMR Assign· April 2011

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Mechanistic insight into human ether-à-go-go-related gene (hERG) K+ channel deactivation gating from the solution structure of the EAG domain.
Frederick W Muskett, Samrat Thouta, Steven J Thomson, Alexander Bowen, Phillip J Stansfeld, John S Mitcheson

J Biol Chem· February 2011

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Revealing the structural basis of action of hERG potassium channel activators and blockers.
Matthew Perry, Michael Sanguinetti, John Mitcheson

J Physiol· September 2010

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Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations.
Phillip J Stansfeld, Alessandro Grottesi, Zara A Sands, Mark S P Sansom, Peter Gedeck, John S Mitcheson

Biochemistry· July 2008

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hERG potassium channels and the structural basis of drug-induced arrhythmias.
John S Mitcheson

Chem Res Toxicol· May 2008

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Activation gating of hERG potassium channels: S6 glycines are not required as gating hinges.
Rachael M Hardman, Phillip J Stansfeld, Sarah Dalibalta, Michael J Sutcliffe, John S Mitcheson

J Biol Chem· November 2007

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Drug block of the hERG potassium channel: insight from modeling.
Phillip J Stansfeld, Peter Gedeck, Martin Gosling, Brian Cox, John S Mitcheson

Proteins· August 2007

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Molecular determinants of HERG channel block.
Kaichiro Kamiya, Ryoko Niwa, John S Mitcheson, Michael C Sanguinetti

Mol Pharmacol· May 2006

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Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs.
Matthew Perry, Phillip J Stansfeld, Joanne Leaney, Claire Wood, Marcel J de Groot, John S Mitcheson

Mol Pharmacol· February 2006

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Molecular mechanisms for drug interactions with hERG that cause long QT syndrome.
Phillip J Stansfeld, Michael J Sutcliffe, John S Mitcheson

Expert Opin Drug Metab Toxicol· February 2006

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Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs.
Michael C Sanguinetti, Jun Chen, David Fernandez, Kaichiro Kamiya, John Mitcheson

Novartis Found Symp· August 2005

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