Publications by authors named "Christopher Hurley"

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Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Mark Zak, Emily J Hanan, Patrick Lupardus, David G Brown, Colin Robinson, Christopher A Hurley

Bioorg Med Chem Lett· June 2019

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Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation.
Roberta Azzarelli, Christopher Hurley, Magdalena K Sznurkowska, Steffen Rulands, Laura Hardwick

Dev Cell· May 2017

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2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors.
Michael Siu, Richard Pastor, Wendy Liu, Kathy Barrett, Megan Berry, Christopher A Hurley

Bioorg Med Chem Lett· September 2013

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A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors.
Sue J Sohn, Kathy Barrett, Anne Van Abbema, Christine Chang, Pawan Bir Kohli, Christopher A Hurley

J Immunol· September 2013

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Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.
Christopher A Hurley, Wade S Blair, Richard J Bull, Christine Chang, Peter H Crackett

Bioorg Med Chem Lett· June 2013

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Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2.
Mark Zak, Christopher A Hurley, Stuart I Ward, Philippe Bergeron, Kathy Barrett

J Med Chem· June 2013

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Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity.
Dean G Brown, Peter R Bernstein, Ye Wu, Rebecca A Urbanek, Christopher W Becker, Christopher A Hurley

ACS Med Chem Lett· January 2013

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Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2.
Sharada Labadie, Peter S Dragovich, Kathy Barrett, Wade S Blair, Philippe Bergeron, Christopher A Hurley

Bioorg Med Chem Lett· December 2012

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Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.
Emily J Hanan, Anne van Abbema, Kathy Barrett, Wade S Blair, Jeff Blaney, Christopher A Hurley

J Med Chem· November 2012

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Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.
Mark Zak, Rohan Mendonca, Mercedesz Balazs, Kathy Barrett, Philippe Bergeron, Christopher A Hurley

J Med Chem· July 2012

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Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors.
Janusz J Kulagowski, Wade Blair, Richard J Bull, Christine Chang, Gauri Deshmukh, Christopher A Hurley

J Med Chem· June 2012

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Mono- and dicationic short PEG and methylene dioxyalkylglycerols for use in synthetic gene delivery systems.
Christopher A Hurley, John B Wong, Jimmy Ho, Michele Writer, Scott A Irvine

Org Biomol Chem· July 2008

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1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity.
Robin D Clark, Nicholas C Ray, Karen Williams, Paul Blaney, Stuart Ward, Christopher Hurley

Bioorg Med Chem Lett· February 2008

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Biophysical characterization of an integrin-targeted lipopolyplex gene delivery vector.
M Firouz Mohd Mustapa, Paul C Bell, Christopher A Hurley, Alastair Nicol, Erwann Guénin

Biochemistry· November 2007

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2-Benzenesulfonyl-8a-benzyl-hexahydro-2H-isoquinolin-6-ones as selective glucocorticoid receptor antagonists.
Robin D Clark, Nicholas C Ray, Paul Blaney, Peter H Crackett, Christopher Hurley

Bioorg Med Chem Lett· October 2007

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Analysis and optimization of the cationic lipid component of a lipid/peptide vector formulation for enhanced transfection in vitro and in vivo.
Michele Writer, Christopher A Hurley, Supti Sarkar, Danielle M Copeman, John B Wong

J Liposome Res· May 2007

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Mannose-pepstatin conjugates as targeted inhibitors of antigen processing.
Paul Free, Christopher A Hurley, Takashi Kageyama, Benjamin M Chain, Alethea B Tabor

Org Biomol Chem· May 2006

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Asymmetric synthesis of dialkyloxy-3-alkylammonium cationic lipids.
Christopher A Hurley, John B Wong, Helen C Hailes, Alethea B Tabor

J Org Chem· February 2004

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