Publications by authors named "Christopher Kochansky"

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Discovery of Potent, Selective and Efficacious Aminopyrazole Inhibitors of PLK4.
Joon Won Jeong, Trevor Chang, Jeremy M Murray, Ryan L Gonciarz, Justin M Salvant, Christopher Kochansky

J Med Chem· December 2025

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2024 White Paper on Recent Issues in Bioanalysis: Three Way-Cross Validation; Urine Clinical Analysis; Automated Methods; Regulatory Queries on Plasma Protein Binding; Automated Biospecimen Management; ELN Migration; Ultra-Sensitivity Mass Spectrometry ( - Recommendations on Advanced Strategies for Mass Spectrometry Assays, Chromatography, Sample Preparation and BMV/Regulated Bioanalysis - Regulatory Agencies' Inputs on Regulated Bioanalysis/BMV).
John Wojcik, Timothy Sikorski, Jian Wang, Yue Huang, Hiroshi Sugimoto, Christopher Kochansky

Bioanalysis· March 2025

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2023 White Paper on Recent Issues in Bioanalysis: Deuterated Drugs; LNP; Tumor/FFPE Biopsy; Targeted Proteomics; Small Molecule Covalent Inhibitors; Chiral Bioanalysis; Remote Regulatory Assessments; Sample Reconciliation/Chain of Custody - Recommendations on Mass Spectrometry, Chromatography, Sample Preparation Latest Developments, Challenges, and Solutions and BMV/Regulated Bioanalysis - Regulatory Agencies' Inputs on Regulated Bioanalysis/BMV, Biomarkers/IVD/CDx/BAV, Immunogenicity, Gene & Cell Therapy and Vaccine).
Mike Baratta, Wenying Jian, Shawna Hengel, Surinder Kaur, Jennifer Cunliffe, Christopher Kochansky

Bioanalysis· June 2024

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Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors.
Chunhui Huang, Christian Fischer, Michelle R Machacek, Stephane Bogen, Tesfaye Biftu, Christopher J Kochansky

ACS Med Chem Lett· April 2022

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Metabolite identification using an ion mobility enhanced data-independent acquisition strategy and automated data processing.
Tatiana Radchenko, Christopher J Kochansky, Mark Cancilla, Mark D Wrona, Russell J Mortishire-Smith

Rapid Commun Mass Spectrom· June 2020

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Decreased liver triglyceride content in adult rats exposed to protein restriction during gestation and lactation: roles of hepatic lipogenesis and lipid utilization in muscle and adipose tissue.
Claudia Mendez-Garcia, Afsana Trini, Veron Browne, Christopher J Kochansky, Laura Pontiggia

Can J Physiol Pharmacol· October 2019

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Administration of Fenofibrate Markedly Elevates Fabp3 in Rat Liver and Plasma and Confounds Its Use as a Preclinical Biomarker of Cardiac and Muscle Toxicity.
Christopher J Kochansky, Michael J Lyman, Scott E Fauty, Katerina Vlasakova, Anil P D'mello

Lipids· October 2018

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Correction: Software-aided approach to investigate peptide structure and metabolic susceptibility of amide bonds in peptide drugs based on high resolution mass spectrometry.
Tatiana Radchenko, Andreas Brink, Yves Siegrist, Christopher Kochansky, Alison Bateman

PLoS One· July 2018

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Software-aided approach to investigate peptide structure and metabolic susceptibility of amide bonds in peptide drugs based on high resolution mass spectrometry.
Tatiana Radchenko, Andreas Brink, Yves Siegrist, Christopher Kochansky, Alison Bateman

PLoS One· December 2017

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Endosomolytic bioreducible poly(amido amine disulfide) polymer conjugates for the in vivo systemic delivery of siRNA therapeutics.
Rubina Giare Parmar, Marina Busuek, Eileen S Walsh, Karen R Leander, Bonnie J Howell, Christopher J Kochansky

Bioconjug Chem· April 2013

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Impact of pH on plasma protein binding in equilibrium dialysis.
Christopher J Kochansky, Daniel R McMasters, Ping Lu, Kenneth A Koeplinger, Haley H Kerr

Mol Pharm· August 2008

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10-Hydroxy-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants.
Catherine M Wiscount, Peter D Williams, Lekhanh O Tran, Mark W Embrey, Thorsten E Fisher, Christopher J Kochansky

Bioorg Med Chem Lett· August 2008

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8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors.
Thorsten E Fisher, Boyoung Kim, Donnette D Staas, Terry A Lyle, Steven D Young, Christopher J Kochansky

Bioorg Med Chem Lett· December 2007

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Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs.
Maria G Beconi, James R Reed, Yohannes Teffera, Yuan-Qing Xia, Christopher J Kochansky

Drug Metab Dispos· April 2007

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The role of P-glycoprotein in the bioactivation of raloxifene.
Jae H Chang, Christopher J Kochansky, Magang Shou

Drug Metab Dispos· December 2006

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Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability.
Donnette D Staas, Kelly L Savage, Vanessa L Sherman, Heidi L Shimp, Terry A Lyle, Christopher J Kochansky

Bioorg Med Chem· October 2006

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Absorption, metabolism, and excretion of [14C]MK-0767 (2-methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in humans.
Christopher J Kochansky, Ronda K Rippley, Kerri X Yan, Hengchang Song, Michael A Wallace

Drug Metab Dispos· September 2006

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Species differences in the elimination of a peroxisome proliferator-activated receptor agonist highlighted by oxidative metabolism of its acyl glucuronide.
Christopher J Kochansky, Yuan-Qing Xia, Sui Wang, Brian Cato, Mellissa Creighton

Drug Metab Dispos· December 2005

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Increasing the efficiency of in-capillary electrophoretically mediated microanalysis reactions via rapid polarity switching.
Brandi D Sanders, Rachel L Slotcavage, Diana L Scheerbaum, Christopher J Kochansky, Timothy G Strein

Anal Chem· April 2005

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Simultaneous determination of MK-0767 and seven metabolites in rat urine using liquid chromatography/tandem mass spectrometry.
Zhongzhou Shen, Christopher Kochansky, Ray Bakhtiar, Ronald B Franklin, Stella H Vincent

Rapid Commun Mass Spectrom· November 2004

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Identification and metabolism of a novel dihydrohydroxy-S-glutathionyl conjugate of a peroxisome proliferator-activated receptor agonist, MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], in rats.
Vijay Bhasker G Reddy, George A Doss, Mellissa Creighton, Christopher J Kochansky, Stella H Vincent

Drug Metab Dispos· October 2004

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Differences in the pharmacokinetics of peroxisome proliferator-activated receptor agonists in genetically obese Zucker and sprague-dawley rats: implications of decreased glucuronidation in obese Zucker rats.
Mi-Sook Kim, Sui Wang, Zhongzhou Shen, Christopher J Kochansky, John R Strauss

Drug Metab Dispos· September 2004

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Metabolism and pharmacokinetics of a dipeptidyl peptidase IV inhibitor in rats, dogs, and monkeys with selective carbamoyl glucuronidation of the primary amine in dogs.
Maria G Beconi, Ann Mao, David Q Liu, Christopher Kochansky, Tony Pereira

Drug Metab Dispos· October 2003

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