Publications by authors named "Terry A Lyle"

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Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease.
Michael T Rudd, John A McCauley, Joseph J Romano, John W Butcher, Kimberly Bush, Terry A Lyle

Bioorg Med Chem Lett· December 2012

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Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.
Michael T Rudd, Charles J McIntyre, Joseph J Romano, John W Butcher, M Katharine Holloway, Terry A Lyle

Bioorg Med Chem Lett· December 2012

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Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold.
Peter D Williams, Donnette D Staas, Shankar Venkatraman, H Marie Loughran, Rowena D Ruzek, Terry A Lyle

Bioorg Med Chem Lett· November 2010

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Bismacrocyclic inhibitors of hepatitis C NS3/4a protease.
John A McCauley, Michael T Rudd, Kevin T Nguyen, Charles J McIntyre, Joseph J Romano, Terry A Lyle

Angew Chem Int Ed Engl· December 2008

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10-Hydroxy-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants.
Catherine M Wiscount, Peter D Williams, Lekhanh O Tran, Mark W Embrey, Thorsten E Fisher, Terry A Lyle

Bioorg Med Chem Lett· August 2008

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8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors.
Thorsten E Fisher, Boyoung Kim, Donnette D Staas, Terry A Lyle, Steven D Young

Bioorg Med Chem Lett· December 2007

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Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors.
John S Wai, Boyoung Kim, Thorsten E Fisher, Linghang Zhuang, Mark W Embrey, Terry A Lyle

Bioorg Med Chem Lett· October 2007

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Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability.
Donnette D Staas, Kelly L Savage, Vanessa L Sherman, Heidi L Shimp, Terry A Lyle

Bioorg Med Chem· October 2006

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Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization.
James Z Deng, Daniel R McMasters, Philippe M A Rabbat, Peter D Williams, Craig A Coburn, Terry A Lyle

Bioorg Med Chem Lett· October 2005

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P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold.
Philippe G Nantermet, Christopher S Burgey, Kyle A Robinson, Janetta M Pellicore, Christina L Newton, Terry A Lyle

Bioorg Med Chem Lett· June 2005

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Low molecular weight thrombin inhibitors with excellent potency, metabolic stability, and oral bioavailability.
Matthew M Morrissette, Kenneth J Stauffer, Peter D Williams, Terry A Lyle, Joseph P Vacca, Elizabeth A Lyle

Bioorg Med Chem Lett· August 2004

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Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. Implementation of P3 pyridine N-oxides to deliver an orally bioavailable series containing P1 N-benzylamides.
Christopher S Burgey, Kyle A Robinson, Terry A Lyle, Philippe G Nantermet, Harold G Selnick, Elizabeth A Lyle

Bioorg Med Chem Lett· April 2003

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Azaindoles: moderately basic P1 groups for enhancing the selectivity of thrombin inhibitors.
Philip E J Sanderson, Matthew G Stanton, Bruce D Dorsey, Terry A Lyle, Colleen McDonough

Bioorg Med Chem Lett· March 2003

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Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines.
Christopher S Burgey, Kyle A Robinson, Terry A Lyle, Philip E J Sanderson, S Dale Lewis, Elizabeth A Lyle

J Med Chem· February 2003

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