Publications by authors named "Elizabeth A Lyle"

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P3 optimization of functional potency, in vivo efficacy and oral bioavailability in 3-aminopyrazinone thrombin inhibitors bearing non-charged groups at the P1 position.
Richard C A Isaacs, Christina L Newton, Kellie J Cutrona, Swati P Mercer, Bruce D Dorsey, Elizabeth A Lyle

Bioorg Med Chem Lett· March 2011

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Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors.
Richard C A Isaacs, Christina L Newton, Kellie J Cutrona, Swati P Mercer, Linda S Payne, Elizabeth A Lyle

Bioorg Med Chem Lett· March 2011

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Characterization of the cell surface glycolipid from Spirochaeta aurantia.
Catherine J Paul, Elizabeth A Lyle, Terry J Beveridge, Richard I Tapping, Andrew M Kropinski

Glycoconj J· December 2009

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Risk of hand or glove contamination after contact with patients colonized with vancomycin-resistant enterococcus or the colonized patients' environment.
Mary K Hayden, Donald W Blom, Elizabeth A Lyle, Charity G Moore, Robert A Weinstein

Infect Control Hosp Epidemiol· February 2008

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Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy.
Christopher M Johnson, Elizabeth A Lyle, Katherine O Omueti, Vitaly A Stepensky, Olcay Yegin

J Immunol· June 2007

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The polymorphism P315L of human toll-like receptor 1 impairs innate immune sensing of microbial cell wall components.
Katherine O Omueti, Daniel J Mazur, Katherine S Thompson, Elizabeth A Lyle, Richard I Tapping

J Immunol· May 2007

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Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist.
Nigel J Liverton, Rodney A Bednar, Bohumil Bednar, John W Butcher, Christopher F Claiborne, Elizabeth A Lyle

J Med Chem· February 2007

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Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centred pattern recognition apparatus.
George Hajishengallis, Richard I Tapping, Evlambia Harokopakis, So-ichiro Nishiyama, Pukar Ratti, Elizabeth A Lyle

Cell Microbiol· October 2006

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Reduction in acquisition of vancomycin-resistant enterococcus after enforcement of routine environmental cleaning measures.
Mary K Hayden, Marc J M Bonten, Donald W Blom, Elizabeth A Lyle, David A M C van de Vijver

Clin Infect Dis· June 2006

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Domain exchange between human toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination.
Katherine O Omueti, John M Beyer, Christopher M Johnson, Elizabeth A Lyle, Richard I Tapping

J Biol Chem· November 2005

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9-hydroxyazafluorenes and their use in thrombin inhibitors.
Kenneth J Stauffer, Peter D Williams, Harold G Selnick, Philippe G Nantermet, Christina L Newton, Elizabeth A Lyle

J Med Chem· April 2005

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Toll-like receptor 2 mediates cellular activation by the B subunits of type II heat-labile enterotoxins.
George Hajishengallis, Richard I Tapping, Michael H Martin, Hesham Nawar, Elizabeth A Lyle

Infect Immun· March 2005

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Transfer of vancomycin-resistant enterococci via health care worker hands.
Amy N Duckro, Donald W Blom, Elizabeth A Lyle, Robert A Weinstein, Mary K Hayden

Arch Intern Med· February 2005

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The structure and biological characteristics of the Spirochaeta aurantia outer membrane glycolipid LGLB.
Evgeny Vinogradov, Catherine J Paul, Jianjun Li, Yuchen Zhou, Elizabeth A Lyle

Eur J Biochem· December 2004

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Differential effects of sodium nitroprusside and hydralazine in a rat model of topical FeCl3-induced carotid artery thrombosis.
Mary A Robinson, Denise C Welsh, Denise J Bickel, Joseph J Lynch, Elizabeth A Lyle

Thromb Res· August 2004

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Low molecular weight thrombin inhibitors with excellent potency, metabolic stability, and oral bioavailability.
Matthew M Morrissette, Kenneth J Stauffer, Peter D Williams, Terry A Lyle, Joseph P Vacca, Elizabeth A Lyle

Bioorg Med Chem Lett· August 2004

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Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. Implementation of P3 pyridine N-oxides to deliver an orally bioavailable series containing P1 N-benzylamides.
Christopher S Burgey, Kyle A Robinson, Terry A Lyle, Philippe G Nantermet, Harold G Selnick, Elizabeth A Lyle

Bioorg Med Chem Lett· April 2003

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3-amino-4-sulfonylpyridinone acetamide and related pyridothiadiazine thrombin inhibitors.
Philip E J Sanderson, Kellie J Cutrona, Kelly L Savage, Adel M Naylor-Olsen, Denise J Bickel, Elizabeth A Lyle

Bioorg Med Chem Lett· April 2003

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Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines.
Christopher S Burgey, Kyle A Robinson, Terry A Lyle, Philip E J Sanderson, S Dale Lewis, Elizabeth A Lyle

J Med Chem· February 2003

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