Publications by authors named "Christopher Sinz"

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HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity.
Skyler Y Blume, Ankur Garg, Yolanda Martí-Mateos, Ayush D Midha, Brandon T L Chew, Christopher Sinz

Cell· March 2025

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Multimodal Imaging Reveals that Sustained Inhibition of HIF-Prolyl Hydroxylases Induces Opposing Effects on Right and Left Ventricular Function in Healthy Rats.
Gain Robinson, Mark Zielstorff, Raquel Sevilla, Amy Vanko, Christopher Sinz

Mol Imaging Biol· February 2024

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Correction: Multimodal Imaging Reveals that Sustained Inhibition of HIF-Prolyl Hydroxylases Induces Opposing Effects on Right and Left Ventricular Function in Healthy Rats.
Gain Robinson, Mark Zielstorff, Raquel Sevilla, Amy Vanko, Christopher Sinz

Mol Imaging Biol· February 2024

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Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders.
Julie C Ullman, Kevin T Mellem, Yannan Xi, Vyas Ramanan, Hanne Merritt, Christopher Sinz

Sci Transl Med· January 2024

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Discovery of novel N-1 substituted pyrazolopyrimidinones as potent, selective PDE2 inhibitors.
Gregori J Morriello, Michael P Dwyer, Yili Chen, Anthony T Ginetti, Shimin Xu, Christopher Sinz

Bioorg Med Chem Lett· July 2021

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Small molecule glucagon receptor antagonists: an updated patent review (2015-2019).
Chen Cheng, Salman Jabri, Brandon M Taoka, Christopher J Sinz

Expert Opin Ther Pat· July 2020

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Selective N7 Alkylation of 7-Azaindazoles.
Zhiyu Lei, Jianming Bao, Chen Cheng, Wensheng Yu, Bin Hu, Christopher J Sinz

J Org Chem· June 2020

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Discovery of Orally Bioavailable and Liver-Targeted Hypoxia-Inducible Factor Prolyl Hydroxylase (HIF-PHD) Inhibitors for the Treatment of Anemia.
Ping Liu, Liping Wang, Byron G DuBois, Vincent J Colandrea, Rongqiang Liu, Christopher J Sinz

ACS Med Chem Lett· December 2018

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Corrigendum to "Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects" [Bioorg. Med. Chem. Lett. 26 (2016) 5724-5728].
Matthew Lombardo, Kate Bender, Clare London, Michael A Plotkin, Melissa Kirkland, Christopher J Sinz

Bioorg Med Chem Lett· March 2017

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Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists.
Jason M Cox, Hong D Chu, Mariappan V Chelliah, John S Debenham, Keith Eagen, Christopher J Sinz

ACS Med Chem Lett· January 2017

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Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects.
Matthew Lombardo, Kate Bender, Clare London, Michael A Plotkin, Melissa Kirkland, Christopher J Sinz

Bioorg Med Chem Lett· December 2016

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Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.
Liangqin Guo, Dann L Parker, Yi Zang, Ramzi F Sweis, Weiguo Liu, Christopher J Sinz

ACS Med Chem Lett· December 2016

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Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes.
Jonathan E Wilson, Ravi Kurukulasuriya, Christopher Sinz, Matthew Lombardo, Kate Bender

Bioorg Med Chem Lett· June 2016

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A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice.
Da Young Oh, Evelyn Walenta, Taro E Akiyama, William S Lagakos, Denise Lackey, Christopher Sinz

Nat Med· August 2014

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Modeling a crowdsourced definition of molecular complexity.
Robert P Sheridan, Nicolas Zorn, Edward C Sherer, Louis-Charles Campeau, Charlie Zhenyu Chang, Christopher J Sinz

J Chem Inf Model· June 2014

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Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.
Maja S Engelstoft, Won-Mee Park, Ichiro Sakata, Line V Kristensen, Anna Sofie Husted, Christopher J Sinz

Mol Metab· December 2013

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Small molecule activation of lecithin cholesterol acyltransferase modulates lipoprotein metabolism in mice and hamsters.
Zhu Chen, Sheng-ping Wang, Mihajlo L Krsmanovic, Jose Castro-Perez, Karen Gagen, Christopher J Sinz

Metabolism· April 2012

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Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists.
Christopher Sinz, Jiang Chang, Ashley Rouse Lins, Ed Brady, Mari Candelore

Bioorg Med Chem Lett· December 2011

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Discovery of N-aryl-2-acylindole human glucagon receptor antagonists.
Christopher Sinz, Amy Bittner, Ed Brady, Mari Candelore, Qing Dallas-Yang

Bioorg Med Chem Lett· December 2011

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Total synthesis of diazonamide A.
Robert R Knowles, Joseph Carpenter, Simon B Blakey, Akio Kayano, Ian K Mangion, Christopher J Sinz

Chem Sci· December 2010

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Enantioselective organocatalytic construction of pyrroloindolines by a cascade addition-cyclization strategy: synthesis of (-)-flustramine B.
Joel F Austin, Sung-Gon Kim, Christopher J Sinz, Wen-Jing Xiao, David W C MacMillan

Proc Natl Acad Sci U S A· April 2004

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The direct and enantioselective organocatalytic alpha-oxidation of aldehydes.
Sean P Brown, Michael P Brochu, Christopher J Sinz, David W C MacMillan

J Am Chem Soc· September 2003

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Total Synthesis of Dermostatin A.
Christopher J Sinz, Scott D Rychnovsky

Angew Chem Int Ed Engl· September 2001

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