Publications by authors named "Mari Candelore"

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A
Anti-diabetic efficacy and impact on amino acid metabolism of GRA1, a novel small-molecule glucagon receptor antagonist.
James Mu, Sajjad A Qureshi, Edward J Brady, Eric S Muise, Mari Rios Candelore

PLoS One· May 2013

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Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the treatment of type II diabetes.
Yusheng Xiong, Jian Guo, Mari R Candelore, Rui Liang, Corey Miller

J Med Chem· July 2012

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D
Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists.
Christopher Sinz, Jiang Chang, Ashley Rouse Lins, Ed Brady, Mari Candelore

Bioorg Med Chem Lett· December 2011

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D
Discovery of N-aryl-2-acylindole human glucagon receptor antagonists.
Christopher Sinz, Amy Bittner, Ed Brady, Mari Candelore, Qing Dallas-Yang

Bioorg Med Chem Lett· December 2011

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D
Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core.
Dong-Ming Shen, Edward J Brady, Mari R Candelore, Qing Dallas-Yang, Victor D-H Ding

Bioorg Med Chem Lett· January 2011

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D
Discovery of potent, orally active benzimidazole glucagon receptor antagonists.
Ronald M Kim, Jiang Chang, Ashley R Lins, Ed Brady, Mari R Candelore

Bioorg Med Chem Lett· July 2008

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D
Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor.
Rui Liang, Lauren Abrardo, Edward J Brady, Mari Rios Candelore, Victor Ding

Bioorg Med Chem Lett· February 2007

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Cloning and expression of canine glucagon receptor and its use to evaluate glucagon receptor antagonists in vitro and in vivo.
Xiaodong Yang, Marla L Yates, Mari R Candelore, William Feeney, Don Hora

Eur J Pharmacol· January 2007

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D
Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptor.
Sheila M Cohen, Joseph L Duffy, Corin Miller, Brian A Kirk, Mari Rios Candelore

Bioorg Med Chem· March 2006

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D
Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists.
Dong-Ming Shen, Fengqi Zhang, Edward J Brady, Mari Rios Candelore, Qing Dallas-Yang

Bioorg Med Chem Lett· October 2005

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D
Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor.
Joseph L Duffy, Brian A Kirk, Zenon Konteatis, Elizabeth L Campbell, Rui Liang, Mari Rios Candelore

Bioorg Med Chem Lett· March 2005

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Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists.
Qing Dallas-Yang, Xiaolan Shen, Mathias Strowski, Edward Brady, Richard Saperstein, Mari Rios Candelore

Eur J Pharmacol· October 2004

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Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor.
Mari Rios Candelore, Michael J Wright, Laurie M Tota, James Milligan, Gan-ju Shei

Biochem Biophys Res Commun· September 2002

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