Publications by authors named "Chrysa Malosh"

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mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome.
Rocco G Gogliotti, Rebecca K Senter, Jerri M Rook, Ayan Ghoshal, Rocio Zamorano, Chrysa Malosh

Hum Mol Genet· May 2016

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Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death.
Constance Ahowesso, Paul N Black, Nipun Saini, David Montefusco, Jessica Chekal, Chrysa Malosh

Biochem Pharmacol· November 2015

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Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators.
Chrysa Malosh, Mark Turlington, Thomas M Bridges, Jerri M Rook, Meredith J Noetzel

Bioorg Med Chem Lett· November 2015

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Further optimization of the mGlu5 PAM clinical candidate VU0409551/JNJ-46778212: Progress and challenges towards a back-up compound.
Ya Zhou, Chrysa Malosh, Susana Conde-Ceide, Carlos Manuel Martínez-Viturro, Jesus Alcázar

Bioorg Med Chem Lett· September 2015

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Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).
Mark Turlington, Chrysa Malosh, Jon Jacobs, Jason T Manka, Meredith J Noetzel

J Med Chem· July 2014

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Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site.
Karen J Gregory, Elizabeth D Nguyen, Chrysa Malosh, Jeffrey L Mendenhall, Jessica Z Zic

ACS Chem Neurosci· April 2014

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Catalytic cross-coupling of alkylzinc halides with alpha-chloroketones.
Chrysa F Malosh, Joseph M Ready

J Am Chem Soc· August 2004

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