Publications by authors named "Jason T Manka"

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Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).
Mark Turlington, Chrysa Malosh, Jon Jacobs, Jason T Manka, Meredith J Noetzel

J Med Chem· July 2014

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Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.
Andrew S Felts, Alice L Rodriguez, Ryan D Morrison, Daryl F Venable, Jason T Manka

Bioorg Med Chem Lett· November 2013

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Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1.
Jason T Manka, Alice L Rodriguez, Ryan D Morrison, Daryl F Venable, Hyekyung P Cho

Bioorg Med Chem Lett· September 2013

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Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.
Jerri M Rook, Meredith J Noetzel, Wendy A Pouliot, Thomas M Bridges, Paige N Vinson, Jason T Manka

Biol Psychiatry· March 2013

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Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.
Jason T Manka, Paige N Vinson, Karen J Gregory, Ya Zhou, Richard Williams

Bioorg Med Chem Lett· October 2012

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Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold.
Richard Williams, Jason T Manka, Alice L Rodriguez, Paige N Vinson, Colleen M Niswender

Bioorg Med Chem Lett· March 2011

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Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity.
Ya Zhou, Jason T Manka, Alice L Rodriguez, C David Weaver, Emily L Days

ACS Med Chem Lett· November 2010

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Azo group-assisted nucleophilic aromatic substitutions in haloarene derivatives: preparation of substituted 1-iodo-2,6-bispropylthiobenzenes.
Jason T Manka, Virginia C McKenzie, Piotr Kaszynski

J Org Chem· March 2004

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Synthesis of polyfunctionalized biphenyls as intermediates for a new class of liquid crystals.
Jason T Manka, Fengli Guo, Jianping Huang, Huiyong Yin, John M Farrar

J Org Chem· December 2003

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