Publications by authors named "Mark Turlington"

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Development of Dual Aurora-A and Aurora-B Degrading PROTACs for -Amplified Neuroblastoma.
Sydney E Nelson, James R Tucker, Madelen G Prado, Lillian C Tierney, Sarah L Quigley, Mark Turlington

ChemMedChem· March 2025

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Synthesis and Evaluation of Cereblon-Recruiting HaloPROTACs.
Britton K Ody, Jing Zhang, Sydney E Nelson, Yayun Xie, Ruochuan Liu, Mark Turlington

Chembiochem· November 2023

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Computational Exploration of Potential CFTR Binding Sites for Type I Corrector Drugs.
Anna Lester, Madeline Sandman, Caitlin Herring, Christian Girard, Brandon Dixon, Mark Turlington

Biochemistry· August 2023

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A Biodegradable, Polymer-Supported Oxygen Atom Transfer Reagent.
Erin E Ramey, Elizabeth L Whitman, Cole E Buller, James R Tucker, Charles S Jolly, Mark Turlington, Christopher R Turlington

Polymers (Basel)· April 2023

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Corrigendum: Linkage-Specific Synthesis of Di-ubiquitin Probes Enabled by the Incorporation of Unnatural Amino Acid ThzK.
Han Zhou, Tomaya Carpenter, Xuan Fu, Bo Jin, Britton Ody, Mark Turlington

Chembiochem· June 2022

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Linkage-Specific Synthesis of Di-ubiquitin Probes Enabled by the Incorporation of Unnatural Amino Acid ThzK.
Han Zhou, Tomaya Carpenter, Xuan Fu, Bo Jin, Britton Ody, Mark Turlington

Chembiochem· April 2022

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Diastereoselective Synthesis of Terminal Bromo-Substituted Propargylamines via Generation of Lithium Bromoacetylide and Addition to Chiral --Butanesulfinyl Aldimines.
Charles S Jolly, Emma Kochanowski, Cayden J Dodd, Savannah J Post, Harrison M Hill, Mark Turlington

J Org Chem· February 2021

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Structural Consequences of the 1,2,3-Triazole as an Amide Bioisostere in Analogues of the Cystic Fibrosis Drugs VX-809 and VX-770.
Jake E Doiron, Christina A Le, John Bacsa, Gary W Breton, Kenneth L Martin, Mark Turlington

ChemMedChem· September 2020

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Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809.
Jake E Doiron, Christina A Le, Britton K Ody, Jonathon B Brace, Savannah J Post, Mark Turlington

Chemistry· March 2019

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Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators.
Chrysa Malosh, Mark Turlington, Thomas M Bridges, Jerri M Rook, Meredith J Noetzel

Bioorg Med Chem Lett· November 2015

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Highly Stereoselective Synthesis of Terminal Chloro-Substituted Propargylamines and Further Functionalization.
Savannah Jordan, Samuel A Starks, Michael F Whatley, Mark Turlington

Org Lett· October 2015

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Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency.
Mark Turlington, Meredith J Noetzel, Thomas M Bridges, Paige N Vinson, Thomas Steckler

Bioorg Med Chem Lett· August 2014

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Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).
Mark Turlington, Chrysa Malosh, Jon Jacobs, Jason T Manka, Meredith J Noetzel

J Med Chem· July 2014

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Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions.
Anna L Blobaum, Thomas M Bridges, Frank W Byers, Mark L Turlington, Margrith E Mattmann

Drug Metab Dispos· December 2013

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Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding.
Mark Turlington, Aspen Chun, Sakshi Tomar, Aimee Eggler, Valerie Grum-Tokars

Bioorg Med Chem Lett· November 2013

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Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254).
Mark Turlington, Meredith J Noetzel, Aspen Chun, Ya Zhou, Rocco D Gogliotti

J Med Chem· October 2013

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Total synthesis of stemaphylline N-oxide and related C9a-epimeric analogues.
Michael L Schulte, Mark L Turlington, Sharangdhar S Phatak, Joel M Harp, Shaun R Stauffer

Chemistry· September 2013

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Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease.
Jon Jacobs, Valerie Grum-Tokars, Ya Zhou, Mark Turlington, S Adrian Saldanha

J Med Chem· January 2013

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Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.
James C Tarr, Mark L Turlington, Paul R Reid, Thomas J Utley, Douglas J Sheffler

ACS Chem Neurosci· November 2012

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Characterization of novel synthesized small molecular compounds against non-small cell lung cancer.
Yunge Zhao, Mark Turlington, Damien J LaPar, David R Jones, David A Harris

Ann Thorac Surg· September 2011

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From highly enantioselective catalytic reaction of 1,3-diynes with aldehydes to facile asymmetric synthesis of polycyclic compounds.
Mark Turlington, Yuhao Du, Samuel G Ostrum, Vishaka Santosh, Kathryne Wren

J Am Chem Soc· August 2011

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Reverse the diastereoselectivity of the Rh(I)-catalyzed Pauson-Khand cycloaddition.
Mark Turlington, Lin Pu

Org Lett· August 2011

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Study of the fluorescent properties of partially hydrogenated 1,1'-bi-2-naphthol-amine molecules and their use for enantioselective fluorescent recognition.
Shanshan Yu, Albert M DeBerardinis, Mark Turlington, Lin Pu

J Org Chem· April 2011

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