Publications by authors named "Clark Pan"

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Engineered Fc-glycosylation switch to eliminate antibody effector function.
Qun Zhou, Julie Jaworski, Yanfeng Zhou, Delphine Valente, Joanne Cotton, Clark Pan

MAbs· July 2021

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Generation of FX and Gmds CHOZN host cell lines for the production of afucosylated therapeutic antibodies.
Weiyi Liu, Roshan Padmashali, Omar Quintero Monzon, Dianna Lundberg, Shan Jin, Clark Pan

Biotechnol Prog· January 2021

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Affinity purification of human alpha galactosidase utilizing a novel small molecule biomimetic of alpha-D-galactose.
Brian Dwyer, Jun Hu, Ameya Madduri, Dianna Lundberg, Brian Miller, Muthuraman Meiyappan, Clark Pan

Protein Expr Purif· January 2021

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Engineering an anti-CD52 antibody for enhanced deamidation stability.
Huawei Qiu, Ronnie Wei, Julie Jaworski, Ekaterina Boudanova, Heather Hughes, Clark Q Pan

MAbs· October 2019

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Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis.
Gabriel Birrane, Anne P Beigneux, Brian Dwyer, Bettina Strack-Logue, Kristian Kølby Kristensen, Clark Q Pan, Muthuraman Meiyappan

Proc Natl Acad Sci U S A· January 2019

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Protein Engineering on Human Recombinant Follistatin: Enhancing Pharmacokinetic Characteristics for Therapeutic Application.
Chuan Shen, Andrea Iskenderian, Dianna Lundberg, Tao He, Kathleen Palmieri, Muthuraman Meiyappan, Clark Pan

J Pharmacol Exp Ther· August 2018

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Impact of cysteine variants on the structure, activity, and stability of recombinant human α-galactosidase A.
Huawei Qiu, Denise M Honey, Jonathan S Kingsbury, Anna Park, Ekaterina Boudanova, Clark Q Pan

Protein Sci· September 2015

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Structures of a pan-specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody-antigen interactions.
Aaron Moulin, Magali Mathieu, Catherine Lawrence, Russell Bigelow, Mark Levine, Clark Q Pan

Protein Sci· December 2014

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Site-specific antibody-drug conjugation through glycoengineering.
Qun Zhou, James E Stefano, Charlene Manning, Josephine Kyazike, Bo Chen, Clark Q Pan

Bioconjug Chem· March 2014

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Glycan structure determinants for cation-independent mannose 6-phosphate receptor binding and cellular uptake of a recombinant protein.
Qun Zhou, Luis Z Avila, Paul A Konowicz, John Harrahy, Patrick Finn, Clark Q Pan

Bioconjug Chem· December 2013

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Site-specific PEGylation of human thyroid stimulating hormone to prolong duration of action.
Huawei Qiu, Ekaterina Boudanova, Anna Park, Julie J Bird, Denise M Honey, Clark Q Pan

Bioconjug Chem· March 2013

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Carbohydrate-mediated polyethylene glycol conjugation of TSH improves its pharmacological properties.
Anna Park, Denise M Honey, Lihui Hou, Julie J Bird, Christine Zarazinski, Clark Q Pan

Endocrinology· March 2013

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High-affinity VEGF antagonists by oligomerization of a minimal sequence VEGF-binding domain.
James E Stefano, Julie Bird, Josephine Kyazike, Anthony Wai-Ming Cheng, Ekaterina Boudanova, Clark Q Pan

Bioconjug Chem· December 2012

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Immunosuppressive activity of a novel peptide analog of α-melanocyte stimulating hormone (α-MSH) in experimental autoimmune uveitis.
Andrea E Edling, Danilo Gomes, Timothy Weeden, John Dzuris, Jim Stefano, Clark Pan

J Neuroimmunol· July 2011

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Strategies for Neoglycan conjugation to human acid α-glucosidase.
Qun Zhou, James E Stefano, John Harrahy, Patrick Finn, Luis Avila, Clark Q Pan

Bioconjug Chem· April 2011

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X-ray and biochemical analysis of N370S mutant human acid β-glucosidase.
Ronnie R Wei, Heather Hughes, Susan Boucher, Julie J Bird, Nicholas Guziewicz, Clark Qun Pan

J Biol Chem· January 2011

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A retro-inverso α-melanocyte stimulating hormone analog with MC1R-binding selectivity.
Timothy Weeden, Jim Stefano, Su Duan, Andrea Edling, Lihui Hou, Clark Pan

J Pept Sci· January 2011

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Rational design of a fully active, long-acting PEGylated factor VIII for hemophilia A treatment.
Baisong Mei, Clark Pan, Haiyan Jiang, Hendri Tjandra, Jonathan Strauss

Blood· July 2010

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In vitro and in vivo evaluation of a non-carbohydrate targeting platform for lysosomal proteins.
James E Stefano, Lihui Hou, Denise Honey, Josephine Kyazike, Anna Park, Clark Q Pan

J Control Release· April 2009

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Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D.
Kevan L Hartshorn, Richard Webby, Mitchell R White, Tesfaldet Tecle, Clark Pan

Respir Res· September 2008

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Generation of PEGylated VPAC1-selective antagonists that inhibit proliferation of a lung cancer cell line.
Clark Q Pan, Sarah Hamren, Steve Roczniak, Irene Tom, Mary DeRome

Peptides· March 2008

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Stabilization of a polypeptide in non-aqueous solvents.
Wei Wang, Sheryl Martin-Moe, Clark Pan, Laszlo Musza, Y John Wang

Int J Pharm· March 2008

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Development of a simple and rapid method for producing non-fucosylated oligomannose containing antibodies with increased effector function.
Qun Zhou, Srinivas Shankara, Andre Roy, Huawei Qiu, Scott Estes, Clark Pan

Biotechnol Bioeng· February 2008

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Generation and optimization of human antagonistic antibodies against TIMP-1 as potential therapeutic agents in fibrotic diseases.
Bodo Brocks, Sabine Kraft, Stefan Zahn, Sabine Noll, Clark Pan

Hum Antibodies· August 2007

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Reproducible production of a PEGylated dual-acting peptide for diabetes.
Irene Tom, Vivian Lee, Michael Dumas, Melanie Madanat, Jun Ouyang, Clark Q Pan

AAPS J· June 2007

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