Publications by authors named "Clinton Canal"

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In Vitro Pharmacology of Mitragynine at α-Adrenoceptors.
Yiming Chen, Jordan Seto, Samuel Obeng, Marco Mottinelli, Sushobhan Mukhopadhyay, Clinton E Canal

ACS Chem Neurosci· December 2025

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The Mitragyna speciosa (kratom) alkaloid mitragynine: Analysis of adrenergic α receptor activity in vitro and in vivo.
Samuel Obeng, Morgan L Crowley, Marco Mottinelli, Francisco León, Julio D Zuarth Gonzalez, Clinton E Canal

Eur J Pharmacol· October 2024

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Defined radio wave frequencies attenuate the head-twitch response in mice elicited by (±)-2,5-dimethoxy-4-iodoamphetamine.
Mary O Vu, B Michael Butters, Clinton E Canal, Xavier A Figueroa

Electromagn Biol Med· October 2024

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Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT Receptor Agonist.
Geoffrey B Varty, Clinton E Canal, Tina A Mueller, Joshua A Hartsel, Richa Tyagi

J Med Chem· April 2024

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Altered brain serotonin 5-HT receptor expression and function in juvenile Fmr1 knockout mice.
Tanishka S Saraf, Yiming Chen, Richa Tyagi, Clinton E Canal

Neuropharmacology· March 2024

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The Psychedelic ,-Dipropyltryptamine Prevents Seizures in a Mouse Model of Fragile X Syndrome via a Mechanism that Appears Independent of Serotonin and Sigma1 Receptors.
Richa Tyagi, Tanishka S Saraf, Clinton E Canal

ACS Pharmacol Transl Sci· October 2023

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FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT, 5-HT, and 5-HT Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Knockout Mice.
Tanishka S Saraf, Ryan P McGlynn, Omkar M Bhatavdekar, Raymond G Booth, Clinton E Canal

ACS Chem Neurosci· December 2022

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"Selective" serotonin 5-HT receptor antagonists.
Austen B Casey, Meng Cui, Raymond G Booth, Clinton E Canal

Biochem Pharmacol· June 2022

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Spontaneous seizures in adult Fmr1 knockout mice: FVB.129P2-Pde6bTyrFmr1/J.
Jessica L Armstrong, Tanishka S Saraf, Omkar Bhatavdekar, Clinton E Canal

Epilepsy Res· May 2022

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The Need To Improve Reporting of the Pharmacological Action of New Molecules.
Clinton E Canal, Marcello Leopoldo

ACS Chem Neurosci· January 2022

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Evaluation of lorcaserin as an anticonvulsant in juvenile Fmr1 knockout mice.
Tanishka S Saraf, Daniel E Felsing, Jessica L Armstrong, Raymond G Booth, Clinton E Canal

Epilepsy Res· September 2021

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Activity of ("Kratom") Alkaloids at Serotonin Receptors.
Francisco León, Samuel Obeng, Marco Mottinelli, Yiming Chen, Tamara I King, Clinton E Canal

J Med Chem· September 2021

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NeuroChat with Professor Clinton E. Canal.
Craig W Lindsley, Clinton E Canal

ACS Chem Neurosci· November 2020

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()-5-(2'-Fluorophenyl)-,-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an Knockout Mouse Model of Fragile X Syndrome and Autism Spectrum Disorder.
Jessica L Armstrong, Austen B Casey, Tanishka S Saraf, Munmun Mukherjee, Raymond G Booth, Clinton E Canal

ACS Pharmacol Transl Sci· June 2020

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Structure-Activity Relationship Study of Psychostimulant Synthetic Cathinones Reveals Nanomolar Antagonist Potency of α-Pyrrolidinohexiophenone at Human Muscarinic M Receptors.
Yiming Chen, Clinton E Canal

ACS Chem Neurosci· March 2020

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Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT and 5-HT G protein-coupled receptor affinity, 3D-QSAR and molecular modeling.
Charles K Perry, Austen B Casey, Daniel E Felsing, Rajender Vemula, Mehreen Zaka, Clinton E Canal

Bioorg Med Chem· February 2020

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M100907 and BD 1047 attenuate the acute toxic effects of methamphetamine.
Azizi Ray, Clinton E Canal, J Christopher Ehlen, Kenner C Rice, Kevin Sean Murnane

Neurotoxicology· September 2019

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The synthetic cathinone psychostimulant α-PPP antagonizes serotonin 5-HT receptors: In vitro and in vivo evidence.
Yiming Chen, Bruce E Blough, Kevin S Murnane, Clinton E Canal

Drug Test Anal· July 2019

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Serotonergic Psychedelics: Experimental Approaches for Assessing Mechanisms of Action.
Clinton E Canal

Handb Exp Pharmacol· June 2019

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Ligand-directed serotonin 5-HT receptor desensitization and sensitization.
Daniel E Felsing, Clinton E Canal, Raymond G Booth

Eur J Pharmacol· April 2019

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Effects of the second-generation "bath salt" cathinone alpha-pyrrolidinopropiophenone (α-PPP) on behavior and monoamine neurochemistry in male mice.
Azizi Ray, Neha Milind Chitre, Cedrick Maceo Daphney, Bruce E Blough, Clinton E Canal

Psychopharmacology (Berl)· March 2019

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Can pimavanserin help patients with Parkinson disease psychosis?
Jennifer de la Cruz, Clinton Canal

JAAPA· January 2019

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Classics in Chemical Neuroscience: Aripiprazole.
Austen B Casey, Clinton E Canal

ACS Chem Neurosci· June 2017

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Mutagenesis Analysis Reveals Distinct Amino Acids of the Human Serotonin 5-HT Receptor Underlying the Pharmacology of Distinct Ligands.
Yue Liu, Clinton E Canal, Tania C Cordova-Sintjago, Wanying Zhu, Raymond G Booth

ACS Chem Neurosci· January 2017

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The serotonin 5-HT receptor and the non-addictive nature of classic hallucinogens.
Clinton E Canal, Kevin S Murnane

J Psychopharmacol· January 2017

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