Publications by authors named "Geoffrey B Varty"

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Modification of natural tryptamines for the treatment of neuropsychiatric diseases.
Michael G Palfreyman, Geoffrey B Varty, Erik Stang, Umed Boltaev, Ken Avery

J Psychopharmacol· December 2025

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Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT Receptor Agonist.
Geoffrey B Varty, Clinton E Canal, Tina A Mueller, Joshua A Hartsel, Richa Tyagi

J Med Chem· April 2024

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Antinociceptive effects of potent, selective and brain penetrant muscarinic M positive allosteric modulators in rodent pain models.
Steven M Grauer, Raul Sanoja, Dominic Poulin, Harunor Rashid, Nina Jochnowitz, Geoffrey B Varty

Brain Res· June 2020

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The mGluR2 positive allosteric modulator, SAR218645, improves memory and attention deficits in translational models of cognitive symptoms associated with schizophrenia.
Guy Griebel, Philippe Pichat, Denis Boulay, Vanessa Naimoli, Lisa Potestio, Geoffrey B Varty

Sci Rep· October 2016

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Characterization of a novel vasopressin V1b receptor antagonist, V1B-30N, in animal models of anxiety-like and depression-like behavior.
Robert A Hodgson, Deborra Mullins, Sherry X Lu, Mario Guzzi, Xiaoping Zhang, Geoffrey B Varty

Eur J Pharmacol· May 2014

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SAR110894, a potent histamine H₃-receptor antagonist, displays procognitive effects in rodents.
Guy Griebel, Philippe Pichat, Marie-Pierre Pruniaux, Sandra Beeské, Mati Lopez-Grancha, Geoffrey B Varty

Pharmacol Biochem Behav· August 2012

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Rolapitant (SCH 619734): a potent, selective and orally active neurokinin NK1 receptor antagonist with centrally-mediated antiemetic effects in ferrets.
Ruth A Duffy, Cynthia Morgan, Robert Naylor, Guy A Higgins, Geoffrey B Varty

Pharmacol Biochem Behav· July 2012

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The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide (SCH 655842): comparison of efficacy and side effects across rodent species.
Sherry X Lu, Guy A Higgins, Robert A Hodgson, Lynn A Hyde, Robert A Del Vecchio, Geoffrey B Varty

Eur J Pharmacol· July 2011

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The neurokinin NK2 antagonist, saredutant, ameliorates stress-induced conditions without impairing cognition.
Nancy Rogacki, Matilde Lopez-Grancha, Vanessa Naimoli, Lisa Potestio, Rachel J Stevens, Geoffrey B Varty

Pharmacol Biochem Behav· May 2011

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AVE1625, a cannabinoid CB1 receptor antagonist, as a co-treatment with antipsychotics for schizophrenia: improvement in cognitive function and reduction of antipsychotic-side effects in rodents.
Mark D Black, Rachel J Stevens, Nancy Rogacki, Robert E Featherstone, Yaw Senyah, Geoffrey B Varty

Psychopharmacology (Berl)· May 2011

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Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination.
Robert A Hodgson, Lynn A Hyde, Donald H Guthrie, Mary E Cohen-Williams, Prescott T Leach, Geoffrey B Varty

Pharmacol Biochem Behav· April 2011

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Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A).
Michel R Corboz, Maria A Rivelli, Kevin D McCormick, Yuntao Wan, Himanshu Shah, Geoffrey B Varty

J Pharmacol Exp Ther· April 2011

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Preladenant, a selective A(2A) receptor antagonist, is active in primate models of movement disorders.
Robert A Hodgson, Paul J Bedard, Geoffrey B Varty, Tatiana M Kazdoba, Therese Di Paolo

Exp Neurol· October 2010

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Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models.
Robbie L McLeod, Deen B Tulshian, Donald C Bolser, Geoffrey B Varty, Marco Baptista

Eur J Pharmacol· March 2010

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Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists.
Jack D Scott, Michael W Miller, Sarah W Li, Sue-Ing Lin, Henry A Vaccaro, Geoffrey B Varty

Bioorg Med Chem Lett· November 2009

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Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in rodent models of movement disorders and depression.
Robert A Hodgson, Rosalia Bertorelli, Geoffrey B Varty, Jean E Lachowicz, Angelo Forlani

J Pharmacol Exp Ther· July 2009

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The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety.
Ginny D Ho, John Anthes, Ana Bercovici, John P Caldwell, Kuo-Chi Cheng, Geoffrey B Varty

Bioorg Med Chem Lett· May 2009

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Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: latent inhibition studies in the rat.
Mark D Black, Geoffrey B Varty, Michal Arad, Segev Barak, Amaya De Levie

Psychopharmacology (Berl)· January 2009

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The effects of adenosine A2A receptor antagonists on haloperidol-induced movement disorders in primates.
Geoffrey B Varty, Robert A Hodgson, Annamarie J Pond, Michael E Grzelak, Eric M Parker

Psychopharmacology (Berl)· October 2008

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The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510).
Geoffrey B Varty, Sherry X Lu, Cynthia A Morgan, Mary E Cohen-Williams, Robert A Hodgson

J Pharmacol Exp Ther· August 2008

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Discovery of a novel, potent and orally active series of gamma-lactams as selective NK1 antagonists.
Sunil Paliwal, Gregory A Reichard, Sapna Shah, Michelle Laci Wrobleski, Cheng Wang, Geoffrey B Varty

Bioorg Med Chem Lett· July 2008

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Design, synthesis, and evaluation of fused heterocyclic analogs of SCH 58261 as adenosine A2A receptor antagonists.
Unmesh Shah, Claire M Lankin, Craig D Boyle, Samuel Chackalamannil, William J Greenlee, Geoffrey B Varty

Bioorg Med Chem Lett· July 2008

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Duration of ultrasonic vocalizations in the isolated rat pup as a behavioral measure: sensitivity to anxiolytic and antidepressant drugs.
Robert A Hodgson, Donald H Guthrie, Geoffrey B Varty

Pharmacol Biochem Behav· January 2008

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The effect of caffeine to increase reaction time in the rat during a test of attention is mediated through antagonism of adenosine A2A receptors.
Guy A Higgins, Michael E Grzelak, Annamarie J Pond, Mary E Cohen-Williams, Robert A Hodgson, Geoffrey B Varty

Behav Brain Res· December 2007

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Cyclobutane derivatives as potent NK1 selective antagonists.
Michelle Laci Wrobleski, Gregory A Reichard, Sunil Paliwal, Sapna Shah, Hon-Chung Tsui, Geoffrey B Varty

Bioorg Med Chem Lett· July 2006

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