Publications by authors named "Colin Howes"

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Multi-modal molecular imaging maps the correlation between tumor microenvironments and nanomedicine distribution.
Nicole Strittmatter, Jennifer I Moss, Alan M Race, Daniel Sutton, Jaime Rodriguez Canales, Colin Howes

Theranostics· April 2022

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Low dose prenatal testosterone exposure decreases the corticosterone response to stress in adult male, but not female, mice.
Hayley A Wilson, Emily R Martin, Colin Howes, Cameron S Wasson, Amy E M Newman

Brain Res· February 2020

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Selumetinib-based therapy in uveal melanoma patient-derived xenografts.
Didier Decaudin, Rania El Botty, Béré Diallo, Gerald Massonnet, Justine Fleury, Colin Howes

Oncotarget· April 2018

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Metabolism, Excretion, and Pharmacokinetics of Selumetinib, an MEK1/2 inhibitor, in Healthy Adult Male Subjects.
Angela W Dymond, Colin Howes, Christine Pattison, Karen So, Gabriella Mariani

Clin Ther· November 2016

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Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo.
Susan Ashton, Young Ho Song, Jim Nolan, Elaine Cadogan, Jim Murray, Colin Howes

Sci Transl Med· February 2016

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BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon, Colin Howes

Bioorg Med Chem Lett· August 2010

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The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.
François Baur, David Beattie, David Beer, David Bentley, Michelle Bradley, Colin Howes

J Med Chem· May 2010

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Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.
Nicolas Charrier, Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall, Colin Howes

Bioorg Med Chem Lett· July 2009

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Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.
Nicolas Charrier, Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall, Colin Howes

Bioorg Med Chem Lett· July 2009

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Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability.
Nicolas Charrier, Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall, Colin Howes

J Med Chem· June 2008

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Potent and selective xanthine-based inhibitors of phosphodiesterase 5.
Nichola J Arnold, Ruth Arnold, David Beer, Gurdip Bhalay, Stephen P Collingwood, Colin Howes

Bioorg Med Chem Lett· April 2007

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Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
Ishrut Hussain, Julie Hawkins, David Harrison, Christopher Hille, Gareth Wayne, Colin Howes

J Neurochem· February 2007

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Development of a P-glycoprotein knockout model in rodents to define species differences in its functional effect at the blood-brain barrier.
Leanne Cutler, Colin Howes, Nigel J Deeks, Tania L Buck, Phil Jeffrey

J Pharm Sci· September 2006

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Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters.
David A Sandham, Lucy Barker, David Beattie, David Beer, Louise Bidlake, Colin Howes

Bioorg Med Chem· October 2004

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Stereoselective preparation of N-[(R,R)-(E)-1-(3,4-dichlorobenzyl)-3- (2-oxoazepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamide, a potent and orally active dual neurokinin NK(1)/NK(2) receptor antagonist.
Marc Gerspacher, Christine Lewis, Howard A Ball, Colin Howes, Natarajan Subramanian

J Med Chem· July 2003

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