Publications by authors named "Colin Leech"

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Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways.
Giorgio Basile, Amedeo Vetere, Jiang Hu, Oluwaseun Ijaduola, Yi Zhang, Colin A Leech

Cell Metab· July 2023

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The alpha-7 nicotinic acetylcholine receptor agonist GTS-21 engages the glucagon-like peptide-1 incretin hormone axis to lower levels of blood glucose in db/db mice.
Qinghe Meng, Oleg G Chepurny, Colin A Leech, Napat Pruekprasert, Megan E Molnar

Diabetes Obes Metab· July 2022

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Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon.
Over Cabrera, James Ficorilli, Janice Shaw, Felipe Echeverri, Frank Schwede, Colin A Leech

J Biol Chem· February 2022

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Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation.
Han Xie, Natesh Yepuri, Qinghe Meng, Ravi Dhawan, Colin A Leech

Rev Endocr Metab Disord· December 2020

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New Insights into Beta-Cell GLP-1 Receptor and cAMP Signaling.
Alejandra Tomas, Ben Jones, Colin Leech

J Mol Biol· March 2020

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Correction: Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP.
Oleg G Chepurny, Minos-Timotheos Matsuokas, George Liapakis, Colin A Leech, Brandon T Milliken

J Biol Chem· May 2019

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Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP.
Oleg G Chepurny, Minos-Timotheos Matsoukas, George Liapakis, Colin A Leech, Brandon T Milliken

J Biol Chem· March 2019

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"A-kinase" regulator runs amok to provide a paradigm shift in cAMP signaling.
George G Holz, Oleg G Chepurny, Colin A Leech

J Biol Chem· February 2019

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Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets.
Rajakrishnan Veluthakal, Oleg G Chepurny, Colin A Leech, Frank Schwede, George G Holz

Diabetes· October 2018

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α7 Nicotinic Acetylcholine Receptor Regulates the Function and Viability of L Cells.
Dawei Wang, Qinghe Meng, Colin A Leech, Natesh Yepuri, Linlin Zhang

Endocrinology· September 2018

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Interplay between ER Ca Binding Proteins, STIM1 and STIM2, Is Required for Store-Operated Ca Entry.
Heather A Nelson, Colin A Leech, Richard F Kopp, Michael W Roe

Int J Mol Sci· May 2018

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Publisher Correction: Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors.
Oleg G Chepurny, Ron L Bonaccorso, Colin A Leech, Torsten Wöllert, George M Langford

Sci Rep· April 2018

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Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors.
Oleg G Chepurny, Ron L Bonaccorso, Colin A Leech, Torsten Wöllert, George M Langford

Sci Rep· February 2018

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Stromal Interaction Molecule 1 (STIM1) Regulates ATP-sensitive Potassium () and Store-operated Ca Channels in MIN6 β-Cells.
Colin A Leech, Richard F Kopp, Heather A Nelson, Jyotirmoy Nandi, Michael W Roe

J Biol Chem· February 2017

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Corrigendum: IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.
Tomozumi Takatani, Jun Shirakawa, Michael W Roe, Colin A Leech, Bernhard F Maier

Sci Rep· October 2016

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IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.
Tomozumi Takatani, Jun Shirakawa, Michael W Roe, Colin A Leech, Bernhard F Maier

Sci Rep· July 2016

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GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion.
Oleg G Chepurny, George G Holz, Michael W Roe, Colin A Leech

Mol Endocrinol· June 2016

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Synthetic small molecule GLP-1 secretagogues prepared by means of a three-component indole annulation strategy.
Oleg G Chepurny, Colin A Leech, Martin Tomanik, Maria C DiPoto, Hui Li

Sci Rep· June 2016

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Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.
Frank Schwede, Oleg G Chepurny, Melanie Kaufholz, Daniela Bertinetti, Colin A Leech

Mol Endocrinol· July 2015

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Leptin-stimulated KATP channel trafficking: a new paradigm for β-cell stimulus-secretion coupling?
George G Holz, Oleg G Chepurny, Colin A Leech

Islets· January 2015

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New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice.
George G Holz, Colin A Leech, Oleg G Chepurny

Biochim Biophys Acta· December 2014

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Resveratrol Interferes with Fura-2 Intracellular Calcium Measurements.
Richard F Kopp, Colin A Leech, Michael W Roe

J Fluoresc· March 2014

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Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag.
Oleg G Chepurny, Daniela Bertinetti, Mandy Diskar, Colin A Leech, Parisa Afshari

Mol Endocrinol· August 2013

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Epac2A makes a new impact in β-cell biology.
George G Holz, Oleg G Chepurny, Colin A Leech

Diabetes· August 2013

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Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1.
Susan Clardy-James, Oleg G Chepurny, Colin A Leech, George G Holz, Robert P Doyle

ChemMedChem· April 2013

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