Publications by authors named "Over Cabrera"

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Constructing chimeric mouse islets to study alpha- and delta-cell influence on beta-cell feature.
Alexis Fouque, Masaya Oshima, Nina Mode, Romain Ducellier, Delphine Thibaut, Over Cabrera

Mol Metab· November 2025

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Identification of biomarkers for glycaemic deterioration in type 2 diabetes.
Roderick C Slieker, Louise A Donnelly, Elina Akalestou, Livia Lopez-Noriega, Rana Melhem, Over Cabrera

Nat Commun· May 2023

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Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon.
Over Cabrera, James Ficorilli, Janice Shaw, Felipe Echeverri, Frank Schwede

J Biol Chem· February 2022

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GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice.
Ricardo J Samms, Michael E Christe, Kyla Al Collins, Valentina Pirro, Brian A Droz, Over Cabrera

J Clin Invest· June 2021

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γ-aminobutyric acid stimulates β-cell proliferation through the mTORC1/p70S6K pathway, an effect amplified by Ly49, a novel γ-aminobutyric acid type A receptor positive allosteric modulator.
Ashley Untereiner, Jie Xu, Alpana Bhattacharjee, Over Cabrera, Cheng Hu

Diabetes Obes Metab· November 2020

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Glucose Regulates Microtubule Disassembly and the Dose of Insulin Secretion via Tau Phosphorylation.
Kung-Hsien Ho, Xiaodun Yang, Anna B Osipovich, Over Cabrera, Mansuo L Hayashi

Diabetes· September 2020

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GABA promotes β-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity.
Ashley Untereiner, Shaaban Abdo, Alpana Bhattacharjee, Himaben Gohil, Farzaneh Pourasgari, Over Cabrera

FASEB J· March 2019

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Catechol estrogens stimulate insulin secretion in pancreatic β-cells via activation of the transient receptor potential A1 (TRPA1) channel.
Wenzhen Ma, Xingjuan Chen, Rok Cerne, Samreen K Syed, James V Ficorilli, Over Cabrera

J Biol Chem· February 2019

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LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept.
Tamer Coskun, Kyle W Sloop, Corina Loghin, Jorge Alsina-Fernandez, Shweta Urva, Over Cabrera

Mol Metab· December 2018

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Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus.
Chafiq Hamdouchi, Pranab Maiti, Alan M Warshawsky, Amy C DeBaillie, Keith A Otto, Over Cabrera

J Med Chem· February 2018

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Regulation of Endogenous (Male) Rodent GLP-1 Secretion and Human Islet Insulin Secretion by Antagonism of Somatostatin Receptor 5.
Thomas B Farb, Marta Adeva, Thomas J Beauchamp, Over Cabrera, David A Coates

Endocrinology· November 2017

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The Different Faces of the Pancreatic Islet.
Midhat H Abdulreda, Rayner Rodriguez-Diaz, Over Cabrera, Alejandro Caicedo, Per-Olof Berggren

Adv Exp Med Biol· June 2017

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Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles.
Ana B Bueno, Aaron D Showalter, David B Wainscott, Cynthia Stutsman, Aranzazu Marín, Over Cabrera

J Biol Chem· May 2016

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Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.
Frank Schwede, Oleg G Chepurny, Melanie Kaufholz, Daniela Bertinetti, Colin A Leech, Over Cabrera

Mol Endocrinol· July 2015

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Mitochondrial GTP insensitivity contributes to hypoglycemia in hyperinsulinemia hyperammonemia by inhibiting glucagon release.
Richard G Kibbey, Cheol Soo Choi, Hui-Young Lee, Over Cabrera, Rebecca L Pongratz

Diabetes· December 2014

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Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function.
Rayner Rodriguez-Diaz, Stephan Speier, Ruth Damaris Molano, Alexander Formoso, Itai Gans, Over Cabrera

Proc Natl Acad Sci U S A· December 2012

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Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.
Jeffrey A Pfefferkorn, Angel Guzman-Perez, John Litchfield, Robert Aiello, Judith L Treadway, Over Cabrera

J Med Chem· February 2012

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Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes.
Jianxin Yang, Margit L MacDougall, Michael T McDowell, Li Xi, Ru Wei, Over Cabrera

BMC Genomics· June 2011

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Mesenchymal stem cells enhance allogeneic islet engraftment in nonhuman primates.
Dora M Berman, Melissa A Willman, Dongmei Han, Gary Kleiner, Norman M Kenyon, Over Cabrera

Diabetes· October 2010

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ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic beta cell.
M Caroline Jacques-Silva, Mayrin Correa-Medina, Over Cabrera, Rayner Rodriguez-Diaz, Natalia Makeeva

Proc Natl Acad Sci U S A· April 2010

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Automated, high-throughput assays for evaluation of human pancreatic islet function.
Over Cabrera, M Caroline Jacques-Silva, Dora M Berman, Alberto Fachado, Felipe Echeverri

Cell Transplant· July 2008

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Glutamate is a positive autocrine signal for glucagon release.
Over Cabrera, M Caroline Jacques-Silva, Stephan Speier, Shao-Nian Yang, Martin Köhler

Cell Metab· June 2008

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Noninvasive in vivo imaging of pancreatic islet cell biology.
Stephan Speier, Daniel Nyqvist, Over Cabrera, Jia Yu, R Damaris Molano

Nat Med· May 2008

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Automated, High-Throughput Assays for Evaluation of Human Pancreatic Islet Function.
Over Cabrera, M Caroline Jacques-Silva, Dora M Berman, Alberto Fachado, Felipe Echeverri

Cell Transplant· November 2007

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Interference with tissue factor prolongs intrahepatic islet allograft survival in a nonhuman primate marginal mass model.
Dora M Berman, Over Cabrera, Norman M Kenyon, Joshua Miller, Susan H Tam

Transplantation· August 2007

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