Publications by authors named "Con Panousis"

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A mechanistic model of in vitro plasma activation to evaluate therapeutic kallikrein-kinin system inhibitors.
Alireza Rezvani-Sharif, Hadi Lioe, Steven K Dower, Matthias Pelzing, Con Panousis

PLoS Comput Biol· November 2024

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Structural basis for the inhibition of βFXIIa by garadacimab.
Ieva Drulyte, Rajesh Ghai, Saw Yen Ow, Eugene A Kapp, Adam J Quek, Con Panousis

Structure· October 2024

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High-Throughput IgG Reformatting and Expression Using Hybrid Secretion Signals and InTag Positive Selection Technology.
Georgina Sansome, Veronika Rayzman, Irene Kiess, Michael J Wilson, Con Panousis

Methods Mol Biol· September 2023

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Activated Coagulation FXII: A Unique Target for In Vivo Molecular Imaging.
Aidan P G Walsh, Eefang Yu, James D McFadyen, Viktoria Bongcaron, Mitchell J Moon, Con Panousis

Arterioscler Thromb Vasc Biol· June 2023

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HDX-MS study on garadacimab binding to activated FXII reveals potential binding interfaces through differential solvent exposure.
Saw Yen Ow, Eugene A Kapp, Vesna Tomasetig, Anton Zalewski, Jason Simmonds, Con Panousis

MAbs· January 2023

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Evaluation of Phage Display Biopanning Strategies for the Selection of Anti-Cell Surface Receptor Antibodies.
Nadya Panagides, Lucia F Zacchi, Mitchell J De Souza, Rodrigo A V Morales, Alexander Karnowski, Con Panousis

Int J Mol Sci· July 2022

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A phase I, first-in-human, randomized dose-escalation study of anti-activated factor XII monoclonal antibody garadacimab.
Andrew McKenzie, Anthony Roberts, Sourabh Malandkar, Henrike Feuersenger, Con Panousis

Clin Transl Sci· March 2022

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Pharmacological Inhibition of Factor XIIa Attenuates Abdominal Aortic Aneurysm, Reduces Atherosclerosis, and Stabilizes Atherosclerotic Plaques.
Amy K Searle, Yung-Chih Chen, Maria Wallert, James D McFadyen, Ana C Maluenda, Con Panousis

Thromb Haemost· February 2022

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Coagulation factor-XII induces interleukin-6 by primary lung fibroblasts: a role in idiopathic pulmonary fibrosis?
Jade Jaffar, Laura McMillan, Nick Wilson, Con Panousis, Charles Hardy

Am J Physiol Lung Cell Mol Physiol· February 2022

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Increased potency of recombinant VWF D'D3 albumin fusion proteins engineered for enhanced affinity for coagulation factor VIII.
Jenny Chia, Sabine Pestel, Isabelle Glauser, Kerstin Emmrich, Matthew P Hardy, Con Panousis

J Thromb Haemost· November 2021

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Generation of a humanized FXII knock-in mouse-A powerful model system to test novel anti-thrombotic agents.
Sarah Beck, David Stegner, Stefan Loroch, Ayesha A Baig, Vanessa Göb, Con Panousis

J Thromb Haemost· November 2021

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A novel soluble complement receptor 1 fragment with enhanced therapeutic potential.
Sandra Wymann, Yun Dai, Anup G Nair, Helen Cao, Glenn A Powers, Con Panousis

J Biol Chem· August 2021

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Factor XII blockade inhibits aortic dilatation in angiotensin II-infused apolipoprotein E-deficient mice.
Corey S Moran, Sai-Wang Seto, Erik Biros, Smriti M Krishna, Susan K Morton, Con Panousis

Clin Sci (Lond)· May 2020

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Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells.
Marc Rigau, Simone Ostrouska, Thomas S Fulford, Darryl N Johnson, Katherine Woods, Con Panousis

Science· February 2020

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Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation.
Helen Cao, Mark Biondo, Hadi Lioe, Samantha Busfield, Veronika Rayzman, Con Panousis

J Allergy Clin Immunol· October 2018

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High-Throughput IgG Reformatting and Expression.
Chao-Guang Chen, Georgina Sansome, Michael J Wilson, Con Panousis

Methods Mol Biol· July 2018

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rIgG1 Fc Hexamer Inhibits Antibody-Mediated Autoimmune Disease via Effects on Complement and FcγRs.
Rolf Spirig, Ian K Campbell, Sandra Koernig, Chao-Guang Chen, Bonnie J B Lewis, Con Panousis

J Immunol· April 2018

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Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.
Malgorzata Wygrecka, Djuro Kosanovic, Lukasz Wujak, Katrin Reppe, Ingrid Henneke, Con Panousis

Am J Respir Crit Care Med· July 2017

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CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors.
Con Panousis, Urmi Dhagat, Kirsten M Edwards, Veronika Rayzman, Matthew P Hardy

MAbs· December 2016

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Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis.
Ian K Campbell, David Leong, Kirsten M Edwards, Veronika Rayzman, Milica Ng, Con Panousis

J Immunol· December 2016

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The Coagulation Factor XIIa Inhibitor rHA-Infestin-4 Improves Outcome after Cerebral Ischemia/Reperfusion Injury in Rats.
Jennifer Krupka, Frauke May, Thomas Weimer, Ingo Pragst, Christoph Kleinschnitz, Con Panousis

PLoS One· July 2016

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FXIIa inhibitor rHA-Infestin-4: Safe thromboprotection in experimental venous, arterial and foreign surface-induced thrombosis.
Frauke May, Jennifer Krupka, Marion Fries, Ina Thielmann, Ingo Pragst, Con Panousis

Br J Haematol· June 2016

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Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.
Kerstin Göbel, Susann Pankratz, Chloi-Magdalini Asaridou, Alexander M Herrmann, Stefan Bittner, Con Panousis

Nat Commun· May 2016

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Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III.
Jenny Björkqvist, Steven de Maat, Urs Lewandrowski, Antonio Di Gennaro, Chris Oschatz, Con Panousis

J Clin Invest· August 2015

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Identification of potent antagonist antibodies against mouse IL-13Rα1 using novel bioassays.
Kirsten M Edwards, Huy Huynh, Ranjeeta Prasad, Anne McDonald, Matthew P Hardy, Con Panousis

J Immunol Methods· May 2014

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