Publications by authors named "Constanza Alcaino"

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Incretin hormones and obesity.
Constanza Alcaino, Frank Reimann, Fiona M Gribble

J Physiol· December 2025

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Mechanisms of Activation and Serotonin Release From Human Enterochromaffin Cells.
Constanza Alcaino, Nunzio Guccio, Emily L Miedzybrodzka, Jaden R Quale, Tianyi Lu

Cell Mol Gastroenterol Hepatol· November 2025

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Molecular mechanisms underlying glucose-dependent insulinotropic polypeptide secretion in human duodenal organoids.
Nunzio Guccio, Constanza Alcaino, Emily L Miedzybrodzka, Marta Santos-Hernández, Christopher A Smith

Diabetologia· January 2025

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Smart control lipid-based nanocarriers for fine-tuning gut hormone secretion.
Yining Xu, Cécilia Bohns Michalowski, Jackie Koehler, Tamana Darwish, Nunzio Guccio, Constanza Alcaino

Sci Adv· December 2024

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XVIIth Little Brain Big Brain: an extraordinary meeting in extraordinary times.
Constanza Alcaino, Florencia Carbone, Peter H Neckel, Naomi E B Tjaden

Nat Rev Gastroenterol Hepatol· April 2023

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Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel.
Peter R Strege, Luke M Cowan, Constanza Alcaino, Amelia Mazzone, Christopher A Ahern

Elife· March 2023

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Mechanosensitive release of 5-HT from specialized intestinal epithelial cells.
Constanza Alcaino

Nat Rev Gastroenterol Hepatol· January 2023

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Intestinal enteroendocrine cells rely on ryanodine and IP calcium store receptors for mechanotransduction.
Kaitlyn R Knutson, Sara T Whiteman, Constanza Alcaino, Arnaldo Mercado-Perez, Isabelle Finholm

J Physiol· January 2023

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Specialized Mechanosensory Epithelial Cells in Mouse Gut Intrinsic Tactile Sensitivity.
Anthony J Treichel, Isabelle Finholm, Kaitlyn R Knutson, Constanza Alcaino, Sara T Whiteman

Gastroenterology· February 2022

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NACHO and 14-3-3 promote expression of distinct subunit stoichiometries of the α4β2 acetylcholine receptor.
Simone Mazzaferro, Sara T Whiteman, Constanza Alcaino, Arthur Beyder, Steven M Sine

Cell Mol Life Sci· February 2021

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Identification of intrinsic primary afferent neurons in mouse jejunum.
Carina Guimarães de Souza Melo, Evan N Nicolai, Constanza Alcaino, Tiffany J Cassmann, Sara T Whiteman

Neurogastroenterol Motil· December 2020

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Foundation One Genomic Interrogation of Thyroid Cancers in Patients With Metastatic Disease Requiring Systemic Therapy.
Nicole M Iñiguez-Ariza, Sina Jasim, Mabel M Ryder, Ashish V Chintakuntlawar, John C Morris, Constanza Alcaino

J Clin Endocrinol Metab· July 2020

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microRNA overexpression in slow transit constipation leads to reduced Na1.5 current and altered smooth muscle contractility.
Amelia Mazzone, Peter R Strege, Simon J Gibbons, Constanza Alcaino, Vikram Joshi

Gut· May 2020

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Cx46 hemichannel modulation by nitric oxide: Role of the fourth transmembrane helix cysteine and its possible involvement in cataract formation.
Mauricio A Retamal, Viviana P Orellana, Nicolás J Arévalo, Cristóbal G Rojas, Rodolfo J Arjona

Nitric Oxide· May 2019

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A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release.
Constanza Alcaino, Kaitlyn R Knutson, Anthony J Treichel, Gulcan Yildiz, Peter R Strege

Proc Natl Acad Sci U S A· August 2018

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The fifth subunit of the (α4β2) β2 nicotinic ACh receptor modulates maximal ACh responses.
Karina New, Silvia Garcia Del Villar, Simone Mazzaferro, Constanza Alcaino, Isabel Bermudez

Br J Pharmacol· June 2018

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Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4.
Constanza Alcaino, Kaitlyn Knutson, Philip A Gottlieb, Gianrico Farrugia, Arthur Beyder

Channels (Austin)· May 2017

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Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces.
Fan Wang, Kaitlyn Knutson, Constanza Alcaino, David R Linden, Simon J Gibbons

J Physiol· January 2017

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Role of the Cys Loop and Transmembrane Domain in the Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors.
Constanza Alcaino, Maria Musgaard, Teresa Minguez, Simone Mazzaferro, Manuel Faundez

J Biol Chem· January 2017

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Non-equivalent ligand selectivity of agonist sites in (α4β2)2α4 nicotinic acetylcholine receptors: a key determinant of agonist efficacy.
Simone Mazzaferro, Federica Gasparri, Karina New, Constanza Alcaino, Manuel Faundez

J Biol Chem· August 2014

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Allosteric modulators of α4β2 nicotinic acetylcholine receptors: a new direction for antidepressant drug discovery.
Elena Mantione, Stefano Micheloni, Constanza Alcaino, Karina New, Simone Mazzaferro

Future Med Chem· November 2012

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