Publications by authors named "Maria Musgaard"

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Adiabatic-Bias Molecular Dynamics Simulations Reveal the Impact of Mutations on Muscarinic Antagonist Unbinding Kinetics.
Adriana Coricello, Anna Lisa Chiaravalle, Maria Musgaard, Benjamin Gerald Tehan, Gian Marco Elisi

J Chem Inf Model· July 2025

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The evolving role of hydrogen/deuterium exchange mass spectrometry in early-stage drug discovery.
Srinath Krishnamurthy, Maria Musgaard, Benjamin Gerald Tehan, Ali Jazayeri, Idlir Liko

Curr Opin Struct Biol· June 2025

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Ligand-induced conformational changes in the β1-adrenergic receptor revealed by hydrogen-deuterium exchange mass spectrometry.
Joanna Toporowska, Parth Kapoor, Maria Musgaard, Karolina Gherbi, Kathy Sengmany

Nat Commun· October 2024

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Gain-of-function and loss-of-function variants in GRIA3 lead to distinct neurodevelopmental phenotypes.
Berardo Rinaldi, Allan Bayat, Linda G Zachariassen, Jia-Hui Sun, Yu-Han Ge, Maria Musgaard

Brain· May 2024

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Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure.
Yasmin Bay, Raminta VenskutonytÄ—, Stine M Frantsen, Thor S Thorsen, Maria Musgaard

FEBS J· April 2024

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Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains.
Anna Ananchenko, Maria Musgaard

J Gen Physiol· March 2023

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Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG-CoA reductase inhibition.
Chris Lindsay, Maria Musgaard, Angela J Russell, Rebecca Sitsapesan

Br J Pharmacol· November 2022

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Identification and functional evaluation of GRIA1 missense and truncation variants in individuals with ID: An emerging neurodevelopmental syndrome.
Vardha Ismail, Linda G Zachariassen, Annie Godwin, Mane Sahakian, Sian Ellard, Maria Musgaard

Am J Hum Genet· July 2022

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The V2475F CPVT1 mutation yields distinct RyR2 channel populations that differ in their responses to cytosolic Ca and Mg.
Abigail D Wilson, Jianshu Hu, Charalampos Sigalas, Elisa Venturi, Héctor H Valdivia, Maria Musgaard

J Physiol· December 2021

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Molecular Investigation of Chicken Acid-Sensing Ion Channel 1 β11-12 Linker Isomerization and Channel Kinetics.
Matthew L Rook, Anna Ananchenko, Maria Musgaard, David M MacLean

Front Cell Neurosci· November 2021

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Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1.
Matthew L Rook, Megan Miaro, Tyler Couch, Dana L Kneisley, Maria Musgaard

J Gen Physiol· August 2021

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A single historical substitution drives an increase in acetylcholine receptor complexity.
Johnathon R Emlaw, Christian J G Tessier, Gregory D McCluskey, Melissa S McNulty, Yusuf Sheikh, Maria Musgaard

Proc Natl Acad Sci U S A· February 2021

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Coupling structure with function in acid-sensing ion channels: challenges in pursuit of proton sensors.
Matthew L Rook, Maria Musgaard, David M MacLean

J Physiol· January 2021

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Identification of compounds that bind the centriolar protein SAS-6 and inhibit its oligomerization.
Julia M C Busch, Minos-Timotheos Matsoukas, Maria Musgaard, Georgios A Spyroulias, Philip C Biggin

J Biol Chem· December 2020

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β11-12 linker isomerization governs acid-sensing ion channel desensitization and recovery.
Matthew L Rook, Abby Williamson, John D Lueck, Maria Musgaard, David M Maclean

Elife· February 2020

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Mutational Analysis and Modeling of Negative Allosteric Modulator Binding Sites in AMPA Receptors.
Charlotte Stenum-Berg, Maria Musgaard, Sergei Chavez-Abiega, Christine L Thisted, Lorenzo Barrella

Mol Pharmacol· December 2019

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A dynamically interacting flexible loop assists oligomerisation of the Caenorhabditis elegans centriolar protein SAS-6.
Julia M C Busch, Michèle C Erat, Iris D Blank, Maria Musgaard, Philip C Biggin

Sci Rep· March 2019

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Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour.
Chris Lindsay, Mano Sitsapesan, Wei Mun Chan, Elisa Venturi, William Welch, Maria Musgaard

Sci Rep· October 2018

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Insights into channel dysfunction from modelling and molecular dynamics simulations.
Maria Musgaard, Teresa Paramo, Laura Domicevica, Ole Juul Andersen, Philip C Biggin

Neuropharmacology· April 2018

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Functional Validation of Heteromeric Kainate Receptor Models.
Teresa Paramo, Patricia M G E Brown, Maria Musgaard, Derek Bowie, Philip C Biggin

Biophys J· November 2017

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Role of the Cys Loop and Transmembrane Domain in the Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors.
Constanza Alcaino, Maria Musgaard, Teresa Minguez, Simone Mazzaferro, Manuel Faundez

J Biol Chem· January 2017

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MD Simulations of P-Type ATPases in a Lipid Bilayer System.
Henriette Elisabeth Autzen, Maria Musgaard

Methods Mol Biol· September 2016

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Steered Molecular Dynamics Simulations Predict Conformational Stability of Glutamate Receptors.
Maria Musgaard, Philip C Biggin

J Chem Inf Model· September 2016

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Kainate receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanism.
Patricia M G E Brown, Mark R P Aurousseau, Maria Musgaard, Philip C Biggin, Derek Bowie

J Physiol· April 2016

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Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes.
G Brent Dawe, Maria Musgaard, Mark R P Aurousseau, Naushaba Nayeem, Tim Green

Neuron· March 2016

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