Publications by authors named "Daniel Czyzyk"

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BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction.
Dhirendra K Simanshu, Rui Xu, James P Stice, Daniel J Czyzyk, Siyu Feng

Science· July 2025

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Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin.
Koji Terayama, Shinji Furuzono, Nicole Fer, Wupeng Yan, Lucy C Young, Daniel J Czyzyk

Science· July 2025

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Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation.
Daniel Czyzyk, Wupeng Yan, Simon Messing, William Gillette, Takashi Tsuji

Nat Commun· January 2025

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Prodrug nanotherapy demonstrates anticryptosporidial efficacy in a mouse model of chronic infection.
Amalendu P Ranjan, Daniel J Czyzyk, Griselle Martinez-Traverso, Aygul Sadiqova, Margarita Valhondo

RSC Pharm· December 2024

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Targeting the TS dimer interface in bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa: Virtual screening identifies novel TS allosteric inhibitors.
Victor G Ruiz, Daniel J Czyzyk, Vidya P Kumar, William L Jorgensen, Karen S Anderson

Bioorg Med Chem Lett· August 2020

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Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase.
Daniel J Czyzyk, Margarita Valhondo, William L Jorgensen, Karen S Anderson

FEBS Lett· August 2019

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Novel allosteric covalent inhibitors of bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa identified by virtual screening.
Victor Ruiz, Daniel J Czyzyk, Margarita Valhondo, William L Jorgensen, Karen S Anderson

Bioorg Med Chem Lett· June 2019

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Synthesis, kinetics and inhibition of Escherichia coli Heptosyltransferase I by monosaccharide analogues of Lipid A.
Noreen K Nkosana, Daniel J Czyzyk, Zarek S Siegel, Joy M Cote, Erika A Taylor

Bioorg Med Chem Lett· February 2018

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The Stories Tryptophans Tell: Exploring Protein Dynamics of Heptosyltransferase I from Escherichia coli.
Joy M Cote, Carlos A Ramirez-Mondragon, Zarek S Siegel, Daniel J Czyzyk, Jiali Gao

Biochemistry· February 2017

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A nanotherapy strategy significantly enhances anticryptosporidial activity of an inhibitor of bifunctional thymidylate synthase-dihydrofolate reductase from Cryptosporidium.
Anindita Mukerjee, Pinar Iyidogan, Alejandro Castellanos-Gonzalez, José A Cisneros, Daniel Czyzyk

Bioorg Med Chem Lett· February 2016

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Escherichia coli heptosyltransferase I: investigation of protein dynamics of a GT-B structural enzyme.
Daniel J Czyzyk, Shreya S Sawant, Carlos A Ramirez-Mondragon, Manju M Hingorani, Erika A Taylor

Biochemistry· August 2013

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Lipopolysaccharide biosynthesis without the lipids: recognition promiscuity of Escherichia coli heptosyltransferase I.
Daniel J Czyzyk, Cassie Liu, Erika A Taylor

Biochemistry· December 2011

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Increased GABAergic output in the ventromedial hypothalamus contributes to impaired hypoglycemic counterregulation in diabetic rats.
Owen Chan, Sachin Paranjape, Daniel Czyzyk, Adam Horblitt, Wanling Zhu

Diabetes· May 2011

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Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia.
Wanling Zhu, Daniel Czyzyk, Sachin A Paranjape, Ligang Zhou, Adam Horblitt

Am J Physiol Endocrinol Metab· May 2010

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Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia.
Owen Chan, Haiying Cheng, Raimund Herzog, Daniel Czyzyk, Wanling Zhu

Diabetes· May 2008

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