Publications by authors named "Simon Messing"

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Structural basis for LZTR1 recognition of RAS GTPases for degradation.
Srisathiyanarayanan Dharmaiah, Daniel A Bonsor, Stephanie P Mo, Alvaro Fernandez-Cabrera, Albert H Chan, Simon Messing

Science· September 2025

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A quantitative high-throughput screening pipeline to identify small molecule inhibitors of Chikungunya nsP2 protease.
Shuaizhang Li, Xin Hu, Yong-Mo Ahn, Angelica Medina, Lin Ye, Simon Messing

Sci Rep· September 2025

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Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine.
Anna E Maciag, Yue Yang, Alok K Sharma, David M Turner, Caroline J DeHart, Simon Messing

Proc Natl Acad Sci U S A· May 2025

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Improvements in large-scale production of tobacco etch virus protease.
Simon Messing, Kirsten Barnhart, Matthew Drew, Natalie Granato-Guerrero, Carissa Grose

Protein Expr Purif· April 2025

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Improved production of class I phosphatidylinositol 4,5-bisphosphate 3-kinase.
Simon Messing, Stephanie R T Widmeyer, John-Paul Denson, Jennifer Mehalko, Vanessa E Wall

Protein Expr Purif· January 2025

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Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation.
Daniel Czyzyk, Wupeng Yan, Simon Messing, William Gillette, Takashi Tsuji

Nat Commun· January 2025

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A High-Throughput Screening Pipeline to Identify Methyltransferase and Exonuclease Inhibitors of SARS-CoV-2 NSP14.
Quinlin Hanson, Xin Hu, Sourav Pal, Katlin Recabo, Lin Ye, Simon Messing

Biochemistry· January 2025

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Producing recombinant proteins in Vibrio natriegens.
Matthew Smith, José Sánchez Hernández, Simon Messing, Nitya Ramakrishnan, Brianna Higgins

Microb Cell Fact· July 2024

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Determining KRAS4B-Targeting Compound Specificity by Top-Down Mass Spectrometry.
Robert A D'Ippolito, Grace M Scheidemantle, Dana Rabara, Maria Abreu Blanco, Nitya Ramakrishnan, Simon Messing

Methods Mol Biol· July 2024

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Adapting recombinant bacterial alkaline phosphatase for nucleotide exchange of small GTPases.
Peter H Frank, Min Hong, Brianna Higgins, Shelley Perkins, Troy Taylor, Simon Messing

Protein Expr Purif· June 2024

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A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement.
Robert A D'Ippolito, Dana Rabara, Maria Abreu Blanco, Emily Alberico, Matthew R Drew, Simon Messing

Anal Chem· April 2024

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Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties.
Matthew J Whitley, Timothy H Tran, Megan Rigby, Ming Yi, Srisathiyanarayanan Dharmaiah, Simon Messing

Sci Adv· February 2024

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RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy.
Antonio Cuevas-Navarro, Morgan Wagner, Richard Van, Monalisa Swain, Stephanie Mo, Simon Messing

Sci Adv· July 2023

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Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.
Daniel A Bonsor, Patrick Alexander, Kelly Snead, Nicole Hartig, Matthew Drew, Simon Messing

Nat Struct Mol Biol· October 2022

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Insights into the Cross Talk between Effector and Allosteric Lobes of KRAS from Methyl Conformational Dynamics.
Fa-An Chao, Srisathiyanarayanan Dharmaiah, Troy Taylor, Simon Messing, William Gillette

J Am Chem Soc· March 2022

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RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.
Pau Castel, Srisathiyanarayanan Dharmaiah, Matthew J Sale, Simon Messing, Gabrielle Rizzuto

Proc Natl Acad Sci U S A· August 2021

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Undiagnosed SARS-CoV-2 seropositivity during the first 6 months of the COVID-19 pandemic in the United States.
Heather Kalish, Carleen Klumpp-Thomas, Sally Hunsberger, Holly Ann Baus, Michael P Fay, Simon Messing

Sci Transl Med· July 2021

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Production and Membrane Binding of N-Terminally Acetylated, C-Terminally Farnesylated and Carboxymethylated KRAS4b.
Simon Messing, Constance Agamasu, Matt Drew, Caroline J DeHart, Andrew G Stephen

Methods Mol Biol· June 2021

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Improved production of SARS-CoV-2 spike receptor-binding domain (RBD) for serology assays.
Jennifer Mehalko, Matthew Drew, Kelly Snead, John-Paul Denson, Vanessa Wall, Simon Messing

Protein Expr Purif· March 2021

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KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Timothy H Tran, Albert H Chan, Lucy C Young, Lakshman Bindu, Chris Neale, Simon Messing

Nat Commun· February 2021

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Standardization of ELISA protocols for serosurveys of the SARS-CoV-2 pandemic using clinical and at-home blood sampling.
Carleen Klumpp-Thomas, Heather Kalish, Matthew Drew, Sally Hunsberger, Kelly Snead, Simon Messing

Nat Commun· January 2021

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Mapping a Pandemic: SARS-CoV-2 Seropositivity in the United States.
Heather Kalish, Carleen Klumpp-Thomas, Sally Hunsberger, Holly Ann Baus, Michael P Fay, Simon Messing

medRxiv· January 2021

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Improved production of SARS-CoV-2 spike receptor-binding domain (RBD) for serology assays.
Jennifer Mehalko, Matthew Drew, Kelly Snead, John-Paul Denson, Vanessa Wall, Simon Messing

bioRxiv· November 2020

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Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane.
Que N Van, Cesar A López, Marco Tonelli, Troy Taylor, Ben Niu, Simon Messing

Proc Natl Acad Sci U S A· September 2020

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Anionic Lipids Impact RAS-Binding Site Accessibility and Membrane Binding Affinity of CRAF RBD-CRD.
Timothy Travers, Cesar A López, Constance Agamasu, Jeevapani J Hettige, Simon Messing

Biophys J· August 2020

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