Publications by authors named "Daniel Muthas"

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Metabolomic profiling of patients with lupus nephritis reveals unique metabolites that are modulated through type I interferon inhibition by anifrolumab treatment in a phase 2 trial.
Patrick G Gavin, Erik L Allman, David Jayne, Eduardo Mysler, Zahir Amoura, Daniel Muthas

RMD Open· October 2025

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Lung IL-13 gene signatures are associated with raised tissue eosinophils in COPD.
Karl J Staples, Jodie Ackland, Sruthymol Lukose, Bastian Angermann, Graham Belfield, Daniel Muthas

Respir Res· March 2025

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NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome.
Vancheswaran Gopalakrishnan, Ben Sparklin, Jung Hwan Kim, Jerome Bouquet, Margaret Kehl, Daniel Muthas

Respir Res· January 2025

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Type I interferon blockade with anifrolumab in patients with systemic lupus erythematosus modulates key immunopathological pathways in a gene expression and proteomic analysis of two phase 3 trials.
Tina Baker, Hoda Sharifian, Paul J Newcombe, Patrick G Gavin, Mark N Lazarus, Daniel Muthas

Ann Rheum Dis· July 2024

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Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD.
Ventzislava A Hristova, Alastair Watson, Raghothama Chaerkady, Matthew S Glover, Jodie Ackland, Daniel Muthas

ERJ Open Res· May 2023

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Proteomic profiling of serum identifies a molecular signature that correlates with clinical outcomes in COPD.
Rania Dagher, Paul Fogel, Jingya Wang, David Soussan, Chia-Chien Chiang, Daniel Muthas

PLoS One· December 2022

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Evaluation of FOXO1 Target Engagement Using a Single-Cell Microfluidic Platform.
Suhuur Osman, Claus Bendtsen, Samantha Peel, Linda Yrlid, Daniel Muthas

Anal Chem· November 2021

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Rare variant contribution to human disease in 281,104 UK Biobank exomes.
Quanli Wang, Ryan S Dhindsa, Keren Carss, Andrew R Harper, Abhishek Nag, Daniel Muthas

Nature· September 2021

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Dysregulation of COVID-19 related gene expression in the COPD lung.
Alastair Watson, Lisa Öberg, Bastian Angermann, C Mirella Spalluto, Michael Hühn, Daniel Muthas

Respir Res· May 2021

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Fungal Dysbiosis and Intestinal Inflammation in Children With Beta-Cell Autoimmunity.
Jarno Honkanen, Arja Vuorela, Daniel Muthas, Laura Orivuori, Kristiina Luopajärvi

Front Immunol· March 2021

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Identification of a missense variant in SPDL1 associated with idiopathic pulmonary fibrosis.
Ryan S Dhindsa, Johan Mattsson, Abhishek Nag, Quanli Wang, Louise V Wain, Daniel Muthas

Commun Biol· March 2021

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MODifieR: an Ensemble R Package for Inference of Disease Modules from Transcriptomics Networks.
Hendrik A de Weerd, Tejaswi V S Badam, David Martínez-Enguita, Julia Åkesson, Daniel Muthas

Bioinformatics· June 2020

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Bleomycin hydrolase regulates the release of chemokines important for inflammation and wound healing by keratinocytes.
Rebecca Riise, Lina Odqvist, Johan Mattsson, Susan Monkley, Suado M Abdillahi, Daniel Muthas

Sci Rep· December 2019

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Activation of group 2 innate lymphoid cells after allergen challenge in asthmatic patients.
Carla Winkler, Thomas Hochdörfer, Elisabeth Israelsson, Annemarie Hasselberg, Anders Cavallin, Daniel Muthas

J Allergy Clin Immunol· July 2019

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Unexplored therapeutic opportunities in the human genome.
Tudor I Oprea, Cristian G Bologa, Søren Brunak, Allen Campbell, Gregory N Gan, Daniel Muthas

Nat Rev Drug Discov· May 2018

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Unexplored therapeutic opportunities in the human genome.
Tudor I Oprea, Cristian G Bologa, Søren Brunak, Allen Campbell, Gregory N Gan, Daniel Muthas

Nat Rev Drug Discov· May 2018

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Neutrophils in ulcerative colitis: a review of selected biomarkers and their potential therapeutic implications.
Daniel Muthas, Anna Reznichenko, Clare A Balendran, Gerhard Böttcher, Ib Groth Clausen

Scand J Gastroenterol· February 2017

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The value of integrating pre-clinical data to predict nausea and vomiting risk in humans as illustrated by AZD3514, a novel androgen receptor modulator.
Claire Grant, Lorna Ewart, Daniel Muthas, Damian Deavall, Simon A Smith

Toxicol Appl Pharmacol· April 2016

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Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes.
Helen Garside, Karen F Marcoe, Jessica Chesnut-Speelman, Alison J Foster, Daniel Muthas

Toxicol In Vitro· March 2014

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Novel pseudopeptides incorporating a benzodiazepine-based turn mimetic--targeting Mycobacterium tuberculosis ribonucleotide reductase.
Johanna Nurbo, Daniel J Ericsson, Ulrika Rosenström, Daniel Muthas, Anna M Jansson

Bioorg Med Chem· April 2013

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Exploiting Pharmacological Similarity to Identify Safety Concerns - Listen to What the Data Tells You.
Daniel Muthas, Scott Boyer

Mol Inform· January 2013

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Application of data mining and visualization techniques for the prediction of drug-induced nausea in man.
Joanna Parkinson, Daniel Muthas, Matthew Clark, Scott Boyer, Jean-Pierre Valentin

Toxicol Sci· March 2012

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DrugPred: a structure-based approach to predict protein druggability developed using an extensive nonredundant data set.
Agata Krasowski, Daniel Muthas, Aurijit Sarkar, Stefan Schmitt, Ruth Brenk

J Chem Inf Model· November 2011

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Identification of small peptides mimicking the R2 C-terminus of Mycobacterium tuberculosis ribonucleotide reductase.
Daniel J Ericsson, Johanna Nurbo, Daniel Muthas, Kalle Hertzberg, Gunnar Lindeberg

J Pept Sci· March 2010

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Functionalized 3-amino-imidazo[1,2-a]pyridines: a novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors.
Luke R Odell, Mikael T Nilsson, Johan Gising, Olof Lagerlund, Daniel Muthas

Bioorg Med Chem Lett· August 2009

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