Publications by authors named "Daniel Spinks"

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Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.
Laura A T Cleghorn, Richard J Wall, Sébastien Albrecht, Stuart A MacGowan, Suzanne Norval, Daniel Spinks

J Med Chem· July 2023

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Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent Antileishmanial Activity: Initial SAR and Assessment of Activity.
Michael G Thomas, Manu De Rycker, Richard J Wall, Daniel Spinks, Ola Epemolu

J Med Chem· September 2020

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Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Susan Wyllie, Stephen Brand, Michael Thomas, Manu De Rycker, Chun-Wa Chung, Daniel Spinks

Proc Natl Acad Sci U S A· May 2019

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Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis.
Michael G Thomas, Manu De Rycker, Myriam Ajakane, Sébastian Albrecht, Ana Isabel Álvarez-Pedraglio, Daniel Spinks

J Med Chem· February 2019

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2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas' disease.
Michael G Thomas, Manu De Rycker, Ignacio Cotillo Torrejon, John Thomas, Jennifer Riley, Daniel Spinks

Bioorg Med Chem Lett· October 2018

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Screening a protein kinase inhibitor library against Plasmodium falciparum.
Irene Hallyburton, Raffaella Grimaldi, Andrew Woodland, Beatriz Baragaña, Torsten Luksch, Daniel Spinks

Malar J· November 2017

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Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi.
Stephen Brand, Eun Jung Ko, Elisabet Viayna, Stephen Thompson, Daniel Spinks

J Med Chem· September 2017

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Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.
Daniel Spinks, Victoria Smith, Stephen Thompson, David A Robinson, Torsten Luksch

ChemMedChem· November 2015

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Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
Stephen Brand, Laura A T Cleghorn, Stuart P McElroy, David A Robinson, Victoria C Smith, Daniel Spinks

J Med Chem· January 2012

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Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.
Daniel Spinks, Leah S Torrie, Stephen Thompson, Justin R Harrison, Julie A Frearson

ChemMedChem· January 2012

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Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488.
Victoria C Smith, Laura A T Cleghorn, Andrew Woodland, Daniel Spinks, Irene Hallyburton

ChemMedChem· October 2011

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Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.
Daniel Spinks, Han B Ong, Chidochangu P Mpamhanga, Emma J Shanks, David A Robinson

ChemMedChem· February 2011

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The discovery and SAR of indoline-3-carboxamides--a new series of 5-HT6 antagonists.
Mark Reid, Ian Carlyle, Wilson L Caulfield, Tom R Clarkson, Fiona Cusick, Daniel Spinks, Gayle Spinks

Bioorg Med Chem Lett· June 2010

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Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis.
Leah S Torrie, Susan Wyllie, Daniel Spinks, Sandra L Oza, Stephen Thompson

J Biol Chem· December 2009

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Investigation of trypanothione reductase as a drug target in Trypanosoma brucei.
Daniel Spinks, Emma J Shanks, Laura A T Cleghorn, Stuart McElroy, Deuan Jones

ChemMedChem· December 2009

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Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods.
Susan Wyllie, Sandra L Oza, Stephen Patterson, Daniel Spinks, Stephen Thompson

Mol Microbiol· November 2009

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One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening.
Chidochangu P Mpamhanga, Daniel Spinks, Lindsay B Tulloch, Emma J Shanks, David A Robinson

J Med Chem· July 2009

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2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: a new class of protein tyrosine phosphatase 1B inhibitors.
David R Adams, Achamma Abraham, Jun Asano, Catherine Breslin, Colin A J Dick, Daniel Spinks

Bioorg Med Chem Lett· December 2007

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4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.
Stephen R Fletcher, Frank Burkamp, Peter Blurton, Susan K F Cheng, Robert Clarkson, Daniel Spinks

J Med Chem· January 2002

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