Publications by authors named "Julie A Frearson"

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Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.
Laura A T Cleghorn, Richard J Wall, Sébastien Albrecht, Stuart A MacGowan, Suzanne Norval, Julie A Frearson

J Med Chem· July 2023

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Substituted Aminoacetamides as Novel Leads for Malaria Treatment.
Neil R Norcross, Caroline Wilson, Beatriz Baragaña, Irene Hallyburton, Maria Osuna-Cabello, Julie A Frearson

ChemMedChem· July 2019

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A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors.
Justin R Harrison, Stephen Brand, Victoria Smith, David A Robinson, Stephen Thompson, Julie A Frearson

J Med Chem· September 2018

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Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors.
Tracy Bayliss, David A Robinson, Victoria C Smith, Stephen Brand, Stuart P McElroy, Julie A Frearson

J Med Chem· December 2017

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Screening a protein kinase inhibitor library against Plasmodium falciparum.
Irene Hallyburton, Raffaella Grimaldi, Andrew Woodland, Beatriz Baragaña, Torsten Luksch, Julie A Frearson

Malar J· November 2017

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The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines.
Nicola J Gardner, Peter J Gillespie, Jamie T Carrington, Emma J Shanks, Stuart P McElroy, Julie A Frearson

Cell Chem Biol· August 2017

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Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy.
Beatriz Baragaña, Neil R Norcross, Caroline Wilson, Achim Porzelle, Irene Hallyburton, Julie A Frearson

J Med Chem· November 2016

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Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Beatriz Baragaña, Irene Hallyburton, Marcus C S Lee, Neil R Norcross, Raffaella Grimaldi, Julie A Frearson

Nature· September 2016

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Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials.
Neil R Norcross, Beatriz Baragaña, Caroline Wilson, Irene Hallyburton, Maria Osuna-Cabello, Julie A Frearson

J Med Chem· July 2016

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Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library.
Andrew Woodland, Stephen Thompson, Laura A T Cleghorn, Neil Norcross, Manu De Rycker, Julie A Frearson

ChemMedChem· November 2015

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Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.
Daniel Spinks, Victoria Smith, Stephen Thompson, David A Robinson, Torsten Luksch, Julie A Frearson

ChemMedChem· November 2015

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Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei.
Laura A T Cleghorn, Sébastien Albrecht, Laste Stojanovski, Frederick R J Simeons, Suzanne Norval, Julie A Frearson

J Med Chem· October 2015

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A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Beatriz Baragaña, Irene Hallyburton, Marcus C S Lee, Neil R Norcross, Raffaella Grimaldi, Julie A Frearson

Nature· June 2015

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Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis.
Stephen Brand, Neil R Norcross, Stephen Thompson, Justin R Harrison, Victoria C Smith, Julie A Frearson

J Med Chem· December 2014

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The design and synthesis of potent and selective inhibitors of Trypanosoma brucei glycogen synthase kinase 3 for the treatment of human african trypanosomiasis.
Robert Urich, Raffaella Grimaldi, Torsten Luksch, Julie A Frearson, Ruth Brenk

J Med Chem· September 2014

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A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei.
Michael D Urbaniak, Iain T Collie, Wenxia Fang, Tonia Aristotelous, Susanne Eskilsson, Julie A Frearson

ACS Chem Biol· September 2013

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Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.
Manu De Rycker, Irene Hallyburton, John Thomas, Lorna Campbell, Susan Wyllie, Julie A Frearson

Antimicrob Agents Chemother· July 2013

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From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules.
Andrew Woodland, Raffaella Grimaldi, Torsten Luksch, Laura A T Cleghorn, Kayode K Ojo, Julie A Frearson

ChemMedChem· July 2013

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Optimizing the use of CROs by academia and small companies.
Rachel F Lane, Lauren G Friedman, Curtis Keith, Steven P Braithwaite, Julie A Frearson

Nat Rev Drug Discov· July 2013

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IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening.
Naomi Tidten-Luksch, Raffaella Grimaldi, Leah S Torrie, Julie A Frearson, William N Hunter

PLoS One· September 2012

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Quinol derivatives as potential trypanocidal agents.
Amy Capes, Stephen Patterson, Susan Wyllie, Irene Hallyburton, Iain T Collie, Julie A Frearson

Bioorg Med Chem· February 2012

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Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
Stephen Brand, Laura A T Cleghorn, Stuart P McElroy, David A Robinson, Victoria C Smith, Julie A Frearson

J Med Chem· January 2012

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Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.
Daniel Spinks, Leah S Torrie, Stephen Thompson, Justin R Harrison, Julie A Frearson

ChemMedChem· January 2012

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Identification of inhibitors of the Leishmania cdc2-related protein kinase CRK3.
Laura A T Cleghorn, Andrew Woodland, Iain T Collie, Leah S Torrie, Neil Norcross, Julie A Frearson

ChemMedChem· December 2011

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Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography.
Stephen Patterson, Magnus S Alphey, Deuan C Jones, Emma J Shanks, Ian P Street, Julie A Frearson

J Med Chem· October 2011

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