Publications by authors named "Daniel V Labarbera"

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Breast cancer cell coculture induces normal lung fibroblast transition to CAFs, promoting tumor cell dormancy and therapy resistance.
Marika L Klosowski, Kathryn E Cronise, Eric P Palmer, Kelly McAuliffe, Claire Stratton, Daniel V LaBarbera

Proc Natl Acad Sci U S A· November 2025

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CHD1L in cancer and beyond: structure, oncogenic functions, and therapeutic potential.
Sophia Clune, Paul Awolade, Hector Esquer, Qiong Zhou, Daniel V LaBarbera

J Exp Clin Cancer Res· May 2025

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Targeted Inhibition of CHD1L by OTI-611 Reprograms Chemotherapy and Targeted Therapy-Induced Cell Cycle Arrest and Suppresses Proliferation to Produce Synergistic Antitumor Effects in Breast and Colorectal Cancer.
Hector Esquer, Qiong Zhou, Daniel V LaBarbera

Cells· February 2025

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CHD1L Inhibitor OTI-611 Synergizes with Chemotherapy to Enhance Antitumor Efficacy and Prolong Survival in Colorectal Cancer Mouse Models.
Rita Sala, Hector Esquer, Timothy Kellett, Sophia Clune, Paul Awolade, Daniel V LaBarbera

Int J Mol Sci· December 2024

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CHD1L Regulates Cell Survival in Breast Cancer and Its Inhibition by OTI-611 Impedes the DNA Damage Response and Induces PARthanatos.
Rita Sala, Hector Esquer, Timothy Kellett, Jeffrey T Kearns, Paul Awolade, Daniel V LaBarbera

Int J Mol Sci· August 2024

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Validation of ferroptosis in canine cancer cells to enable comparative oncology and translational medicine.
Priya Chatterji, Gang Xing, Laura Furst, Krishna Dave, Qiong Zhou, Daniel V LaBarbera

bioRxiv· April 2024

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The validation of new CHD1L inhibitors as a therapeutic strategy for cancer.
Sophia Clune, Paul Awolade, Qiong Zhou, Hector Esquer, Brock Matter, Daniel V LaBarbera

Biomed Pharmacother· January 2024

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HTS discovery of PARP1-HPF1 complex inhibitors in cancer.
Timothy Kellett, Rida Noor, Qiong Zhou, Hector Esquer, Rita Sala, Daniel V LaBarbera

SLAS Discov· December 2023

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High-Content Drug Discovery Targeting Molecular Bladder Cancer Subtypes.
Sébastien Rinaldetti, Qiong Zhou, Joshua M Abbott, Florus C de Jong, Hector Esquer, Daniel V LaBarbera

Int J Mol Sci· September 2022

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AST-487 Inhibits RET Kinase Driven TERT Expression in Bladder Cancer.
Neeraj Agarwal, Qiong Zhou, Deepak Arya, Sébastien Rinaldetti, Jason Duex, Daniel V LaBarbera

Int J Mol Sci· September 2022

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Oxidative stress as a candidate mechanism for accelerated neuroectodermal differentiation due to trisomy 21.
Kendra M Prutton, John O Marentette, Brice A Leifheit, Hector Esquer, Daniel V LaBarbera

Free Radic Biol Med· June 2022

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Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L.
Brett J Prigaro, Hector Esquer, Qiong Zhou, Laura A Pike, Paul Awolade, Daniel V LaBarbera

J Med Chem· March 2022

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TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer.
Neeraj Agarwal, Sebastien Rinaldetti, Bassem B Cheikh, Qiong Zhou, Evan P Hass, Daniel V LaBarbera

Proc Natl Acad Sci U S A· September 2021

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Isolating and targeting the real-time plasticity and malignant properties of epithelial-mesenchymal transition in cancer.
Hector Esquer, Qiong Zhou, Travis Nemkov, Adedoyin D Abraham, Sébastien Rinaldetti, Daniel V LaBarbera

Oncogene· April 2021

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Advanced High-Content-Screening Applications of Clonogenicity in Cancer.
Hector Esquer, Qiong Zhou, Adedoyin D Abraham, Daniel V LaBarbera

SLAS Discov· August 2020

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First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer.
Joshua M Abbott, Qiong Zhou, Hector Esquer, Laura Pike, Travis P Broneske, Daniel V LaBarbera

Mol Cancer Ther· August 2020

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High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling.
Keith A Strand, Sizhao Lu, Marie F Mutryn, Linfeng Li, Qiong Zhou, Daniel V LaBarbera

Arterioscler Thromb Vasc Biol· August 2020

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Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer.
Adedoyin D Abraham, Hector Esquer, Qiong Zhou, Nicholas Tomlinson, Brayden D Hamill, Daniel V LaBarbera

J Med Chem· November 2019

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Establishment and Characterization of Four Novel Thyroid Cancer Cell Lines and PDX Models Expressing the RET/PTC1 Rearrangement, BRAFV600E, or RASQ61R as Drivers.
Rebecca E Schweppe, Nikita Pozdeyev, Laura A Pike, Christopher Korch, Qiong Zhou, Daniel V LaBarbera

Mol Cancer Res· May 2019

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Targeting HIV-1 Protease Autoprocessing for High-throughput Drug Discovery and Drug Resistance Assessment.
Liangqun Huang, Linfeng Li, ChihFeng Tien, Daniel V LaBarbera, Chaoping Chen

Sci Rep· January 2019

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Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers.
Nikita Pozdeyev, Laurie M Gay, Ethan S Sokol, Ryan Hartmaier, Kelsi E Deaver, Daniel V LaBarbera

Clin Cancer Res· July 2018

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Identification of small molecule inhibitors of the Chikungunya virus nsP1 RNA capping enzyme.
Kristen M Feibelman, Benjamin P Fuller, Linfeng Li, Daniel V LaBarbera, Brian J Geiss

Antiviral Res· June 2018

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Inhibition of α-glucosidase, α-amylase, and aldose reductase by potato polyphenolic compounds.
Diganta Kalita, David G Holm, Daniel V LaBarbera, J Mark Petrash, Sastry S Jayanty

PLoS One· March 2018

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Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri.
Bharat Bashyal, Linfeng Li, Trpta Bains, Anjan Debnath, Daniel V LaBarbera

PLoS Negl Trop Dis· August 2017

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SBI HCS/HCA 3D Imaging: Best Practices and Unmet Needs Colloquium.
Ann F Hoffman, Kaylene J Simpson, Peter Horvath, Carrie Lovitt, Serena Silver, Daniel V LaBarbera

Assay Drug Dev Technol· January 2017

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